Neuromyelitis optica spectrum disorders with antibodies to myelin oligodendrocyte glycoprotein or aquaporin-4: Clinical and paraclinical characteristics in Algerian patients

Bouzar, Melissa; Daoudi, Smail; Hattab, Samira; Bouzar, Amel A.; Deiva, Kumaran; Wildemann, Brigitte; Reindl, Markus; Jarius, Sven

doi:10.1016/j.jns.2017.08.3254

Cited by 31 publications

(21 citation statements)

References 24 publications

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“…By contrast, lesions in MS-related ON extended only over 1 (70%) or 2 (30%) of 9 segments (intraorbital RE/LE, canalicular RE/LE, intracranial RE/LE, chiasmal, optic tract right/left side) in [ 44 ], and a mean extension of just 2.2/10 segments (orbital RE/LE, canalicular RE/LE, intracranial RE/LE, chiasma right/left half, optic tract right/left side) was observed in MS-ON in [ 46 ]. Longitudinal extensive lesions ranging over more than the half of the distance between the optic nerve head and the chiasm were also reported in 3/3 patients in [ 47 ] and in 6/10 (60%) in [ 3 ]. Finally, 9/10 MOG-ON Han patients (90%) showed involvement of all three segments of the pre-chiasmal optic nerve (intraorbital, canalicular, intracranial) in [ 48 ], in 6 of whom chiasmal and/or optic tract involvement was noted in addition e Observed in 11/28 patients during acute ON in [ 3 ], in 6/18 in [ 49 ], and in 6/8 in [ 48 ], but not usually in MS. Perioptic T2 hyperintensity alone does not count f Positive in ≥ 90% of RRMS patients [ 37 , 36 , 50 ].…”

Section: Recommendations On Mog-igg Testingmentioning

confidence: 99%

MOG encephalomyelitis: international recommendations on diagnosis and antibody testing

Jarius

Paul

Aktaş

et al. 2018

J Neuroinflammation

623

557

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Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD). Owing to a substantial overlap in clinicoradiological presentation, MOG-EM was often unwittingly misdiagnosed as MS in the past. Accordingly, increasing numbers of patients with suspected or established MS are currently being tested for MOG-IgG. However, screening of large unselected cohorts for rare biomarkers can significantly reduce the positive predictive value of a test. To lessen the hazard of overdiagnosing MOG-EM, which may lead to inappropriate treatment, more selective criteria for MOG-IgG testing are urgently needed. In this paper, we propose indications for MOG-IgG testing based on expert consensus. In addition, we give a list of conditions atypical for MOG-EM (“red flags”) that should prompt physicians to challenge a positive MOG-IgG test result. Finally, we provide recommendations regarding assay methodology, specimen sampling and data interpretation.

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Section: Recommendations On Mog-igg Testingmentioning

confidence: 99%

MOG encephalomyelitis: international recommendations on diagnosis and antibody testing

Jarius

Paul

Aktaş

et al. 2018

J Neuroinflammation

623

557

View full text Add to dashboard Cite

show abstract

“…Beyond certain characteristic clinical manifestations and specific neuroimaging findings, the presence of antibodies against water channel aquaporin-4 (AQP4), which is expressed in the astrocyte cell plasma membrane, is central for NMOSD diagnosis. [32] Eighty percent of the NMOSD patients test positive for AQP4-IgG. [124] AQP4 is also associated with peripheral tissues; however, in CNS, it is responsible for maintenance of cerebral water balance, blood–brain barrier development, and integrity.…”

Section: Diagnosis Of Neuromyelitis Opticamentioning

confidence: 99%

Comprehensive review of neuromyelitis optica and clinical characteristics of neuromyelitis optica patients in Puerto Rico

Zarei¹,

Eggert²,

Franqui-Dominguez³

et al. 2018

Surg Neurol Int

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Neuromyelitis optica (NMO) is an immune-mediated inflammatory disorder of the central nervous system. It is characterized by concurrent inflammation and demyelination of the optic nerve (optic neuritis [ON]) and the spinal cord (myelitis). Multiple studies show variations in prevalence, clinical, and demographic features of NMO among different populations. In addition, ethnicity and race are known as important factors on disease phenotype and clinical outcomes. There are little data on information about NMO patients in underserved groups, including Puerto Rico (PR). In this research, we will provide a comprehensive overview of all aspects of NMO, including epidemiology, environmental risk factors, genetic factors, molecular mechanism, symptoms, comorbidities and clinical differentiation, diagnosis, treatment, its management, and prognosis. We will also evaluate the demographic features and clinical phenotype of NMO patients in PR. This will provide a better understanding of NMO and establish a basis of knowledge that can be used to improve care. Furthermore, this type of population-based study can distinguish the clinical features variation among NMO patients and will provide insight into the potential mechanisms that cause these variations.

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“…12 Accumulating evidence has suggested that detection of MOG-IgG defines a clinical syndrome distinct from both multiple sclerosis (MS) and AQP4-IgG seropositive neuromyelitis optica spectrum disorder. 11, [13][14][15][16] In this study, we sought to determine the clinical, radiologic, and laboratory characteristics and outcome of myelitis seropositive for MOG-IgG and compare this disease with myelitis associated with AQP4-IgG and MS.…”

mentioning

confidence: 99%

Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody

et al. 2019

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Neuromyelitis optica spectrum disorders with antibodies to myelin oligodendrocyte glycoprotein or aquaporin-4: Clinical and paraclinical characteristics in Algerian patients

Cited by 31 publications

References 24 publications

MOG encephalomyelitis: international recommendations on diagnosis and antibody testing

MOG encephalomyelitis: international recommendations on diagnosis and antibody testing

Comprehensive review of neuromyelitis optica and clinical characteristics of neuromyelitis optica patients in Puerto Rico

Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody

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