Neuron: A Tool for Neuroscientists

Hines, Michael L.; Carnevale, Nicholas T.

doi:10.1177/107385840100700207

Cited by 589 publications

(491 citation statements)

References 85 publications

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“…GENESIS (102) (an acronym of GEneral NEural SImulation System) was one of the first systems developed for the simulation of biologically realistic models at different levels, ranging from subcellular components and biochemical reactions, to single neurons, large networks, and complete systems models. An analogous simulation environment is NEU-RON (108,119). Both provide ways to construct, test, and manage models, such that expertise in numerical methods or programming is not required for productive use.…”

Section: Simulation Toolsmentioning

confidence: 99%

Neuron tracing in perspective

2010

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The study of the structure and function of neuronal cells and networks is of crucial importance in the endeavor to understand how the brain works. A key component in this process is the extraction of neuronal morphology from microscopic imaging data. In the past four decades, many computational methods and tools have been developed for digital reconstruction of neurons from images, with limited success. As witnessed by the growing body of literature on the subject, as well as the organization of challenging competitions in the field, the quest for a robust and fully automated system of more general applicability still continues. The aim of this work, is to contribute by surveying recent developments in the field for anyone interested in taking up the challenge. Relevant aspects discussed in the article include proposed image segmentation methods, quantitative measures of neuronal morphology, currently available software tools for various related purposes, and morphology databases. ' 2010 International Society for Advancement of Cytometry

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Section: Simulation Toolsmentioning

confidence: 99%

Neuron tracing in perspective

2010

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“…Modeling programs like MCell (Stiles et al, 2001), Neuron (Hines and Carnevale, 2001), and Genesis (Bower and Beeman, 1998) can accommodate realistic branching structures and surface morphologies such as those contained in the CCDB. Surface reconstructions derived from electron tomographic 3D volumes are now being used as the basis for functional simulations of molecular diffusion and interactions using MCell, a powerful Monte Carlo-based modeling package created for simulation of cellular microdomains (Stiles et al, 2001).…”

Section: Resource For Modelersmentioning

confidence: 99%

A cell-centered database for electron tomographic data

Martone

Gupta

Wong

et al. 2002

Journal of Structural Biology

108

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“…Simulations were performed using Neuron (Hines and Carnevale, 2001). For passive simulations, parameters were R m ϭ 50,000 ⍀cm 2 , C m ϭ 1.2 F/cm 2 , R i ϭ 70 ⍀cm.…”

Section: Methodsmentioning

confidence: 99%

Tuft Calcium Spikes in Accessory Olfactory Bulb Mitral Cells

Urban

Castro²

2005

J. Neurosci.

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The mammalian accessory olfactory system is critical for the detection and identification of pheromones and the representation of complex stimuli including sex, genetic relatedness, and individual identity. Mitral cells, the principal cells of the accessory olfactory bulb (AOB), receive monosynaptic input from the sensory periphery and already show highly specific response properties, firing selectively for combinations of genetic markers and gender-specific cues. Vomeronasal sensory neuron axons form synapses onto distal tuft-like branches of mitral cell primary dendrites. We have studied dendritic excitability and synaptic integration in AOB mitral cell dendrites, and we show that dendrites of accessory olfactory bulb mitral cells support action potential propagation and can fire regenerative spike-like events that are likely to contribute to the integration of inputs to these cells. These tuft spikes may be important for the specificity of AOB mitral cell responses.

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Neuron: A Tool for Neuroscientists

Cited by 589 publications

References 85 publications

Neuron tracing in perspective

Neuron tracing in perspective

A cell-centered database for electron tomographic data

Tuft Calcium Spikes in Accessory Olfactory Bulb Mitral Cells

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