Neuron-derived Neurotrophic Factor Functions as a Novel Modulator That Enhances Endothelial Cell Function and Revascularization Processes

Ohashi, Koji; Enomoto, Takashi; Joki, Yusuke; Shibata, Rei; Ogura, Yasuhiro; Kataoka, Yasufumi; Shimizu, Yasuhiko; Kambara, Takahiro; Uemura, Yoshiko; Yuasa, Daisuke; Matsuo, Kazuhiro; Hayakawa, Shinobu; Hiramatsu-Ito, Mizuho; Murohara, Toyoaki; Ouchi, Noriyuki

doi:10.1074/jbc.m114.555789

Cited by 50 publications

(38 citation statements)

References 48 publications

(67 reference statements)

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“…Recently, NDNF has been found to promote vascularization since expressed at high levels by EC of the ischemic muscle in mice. Intramuscular NDNF overexpression increases perfusion and capillary formation in a murine model of ischemia, while NDNF knock-out resulted in an overall reduction of the EC network (180).…”

Section: Brain- Neuron- Glial Cell Line-derived Neurotrophic Factormentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

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Abstract:In the last few years, a growing number of molecules have been associated to an endocrine function of the skeletal muscle. Circulating myokine levels, in turn, have been associated with several pathophysiological conditions including the cardiovascular ones. However, data from different studies are often not completely comparable or even discordant. This would be due, at least in part, to the whole set of situations related to the preparation of the patient prior to blood sampling, blood sampling procedure, processing and/or store. This entire process constitutes the pre-analytical phase. The importance of the preanalytical phase is often not considered. However, in routine diagnostics, the 70% of the errors are in this phase. Moreover, errors during the pre-analytical phase are carried over in the analytical phase and affects the final output. In research, for example, when samples are collected over a long time and by different laboratories, a standardized procedure for sample collecting and the correct procedure for sample storage are acknowledged. In this review, we discuss the pre-analytical variables potentially affecting the measurement of myokines with cardiovascular functions.

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Section: Brain- Neuron- Glial Cell Line-derived Neurotrophic Factormentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

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“…NDNF was selected as one of potential secreted molecules that are upregulated by ischemia after screening of differentially regulated genes in nonischemic and ischemic muscle tissues of mice. 71 Interestingly, NDNF expression is observed in endothelial cells rather than in myocytes in skeletal muscle tissue. 71 Ischemic insult in the hindlimb leads to enhanced expression in muscle, which is accompanied by increased levels of circulating NDNF.…”

Section: Myokinesmentioning

confidence: 99%

“…71 Interestingly, NDNF expression is observed in endothelial cells rather than in myocytes in skeletal muscle tissue. 71 Ischemic insult in the hindlimb leads to enhanced expression in muscle, which is accompanied by increased levels of circulating NDNF. NDNF secretion from endothelial cells is enhanced in response to hypoxia.…”

Section: Myokinesmentioning

confidence: 99%

“…Intramuscular injection of NDNF enhances blood flow recovery and capillary formation in ischemic limbs of mice. 71 Moreover, downregulation of muscle NDNF by siRNA technique leads to reduction of perfusion recovery in response to ischemia. Thus, NDNF serves as an endogenous ischemia-inducible factor secreted from skeletal muscle that can enhance endothetiation of endothelial cells into network structures and inhibits apoptosis.…”

Section: Myokinesmentioning

confidence: 99%

“…68-70 Neuron-derived neurotrophic factor (NDNF)/epidermacan was identified as a secreted molecule that is upregulated in ischemic limbs of mice. 71 NDNF is reported to prevent endothelial cell injury and the adverse cardiac remodeling in response to ischemia. 72 Although most of the previously studied myokines act as metabolic regulators, these myokines appear to exert cardiovascular protective effects as described next in detail.…”

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confidence: 99%

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Protective Roles of Adipocytokines and Myokines in Cardiovascular Disease

Ouchi

Ohashi

Shibata

et al. 2016

Circ J

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Obesity is a major risk factor for progression of cardiovascular disease. Adipose tissue is recognized as an endocrine organ producing various secretory molecules, also known as adipocytokines, and dysregulated production of adipocytokines participates in the pathogenesis of obesity complications, including metabolic dysfunction and cardiovascular disorders. Recent evidence indicates that skeletal muscle also functions as an endocrine organ capable of secreting a number of bioactive substances, also referred to as myokines. Several myokines are involved in metabolic and cardiovascular regulation. This review will discuss the clinical and experimental studies that have investigated the protective role of several adipocytokines and myokines in cardiovascular diseases. (Circ J 2016; 80: 2073 -2080

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Effects of combination treatment with durvalumab plus tremelimumab on the tumor microenvironment in non-small-cell lung carcinoma

Creasy

Pilataxi

et al. 2021

Cancer Immunol Immunother

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The rapid development of immune checkpoint blockade (ICB) therapies has revolutionized the cancer treatment landscape and brightened the long-term forecast for many cancer patients. However, the specific genomic and proteomic changes in tumors treated with different ICB treatments have yet to be fully characterized. We treated four non-small-cell lung carcinoma (NSCLC) tumor digests ex vivo with the anti-PD-L1 antibody durvalumab (D) alone or in combination with the anti-CTLA-4 antibody tremelimumab (T) to explore changes in gene and protein expression associated with these ICB therapies. All four tumors showed a robust increase in interferon gamma (IFN-γ) production (100–300% higher than isotype control) in both D- and D + T-treated tumors. Three of the four tumors showed additional increases in IFN-γ production with D + T compared with D (40–70%). A substantial reduction in interleukin 10 (IL-10) was also found in three of the four tumors (reduced to 4–8%) in response to D and D + T. Conventional CD4 + /CD8 + populations and T cell activation markers increased after D and D + T treatment. D and D + T upregulated multiple IPA pathways involving T cell activation. D + T resulted in additional upregulation of Th1/Th2 pathways through a different set of genes, as well as greater reduction in genes involved in epithelial-mesenchymal transition (EMT), angiogenesis, and cancer stemness. Our results demonstrated that D + T augmented the effects of D in the microenvironment of this set of NSCLC tumors. The specific impact of D + T on the regulation of EMT, angiogenesis, and cancer stemness warrants further evaluation in a larger set of tumors.

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Neuron-derived Neurotrophic Factor Functions as a Novel Modulator That Enhances Endothelial Cell Function and Revascularization Processes

Cited by 50 publications

References 48 publications

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Protective Roles of Adipocytokines and Myokines in Cardiovascular Disease

Effects of combination treatment with durvalumab plus tremelimumab on the tumor microenvironment in non-small-cell lung carcinoma

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