2024
DOI: 10.21203/rs.3.rs-4360587/v1
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Neuron-type specific aging-rate reveals age decelerating interventions preventing neurodegeneration

Björn Schumacher,
Christian Gallrein,
David Meyer

Abstract: Different types of neurons show distinct susceptibility to age-dependent functional decline and degeneration and are linked to different types of neurodegenerative disorders. The underlying reasons for different aging trajectories of distinct neuron types are poorly understood. Here, we employ aging clocks to assess whether distinct neurons differ in their biological age trajectory in C. elegans where the identity of each single neuron is known. We find that specifically ciliated sensory neurons with high neur… Show more

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