Neuronal Cell Protective Effects of Hot Water Extracts from Guava (Psidium guajava L.) Fruit and Leaf

Jeong, Chang-Ho; Jeong, Hee-Rok; Choi, Gwi-Nam; Kwak, Ji-Hyun; Kim, Jihye; Park, Soo-Jeong; Kim, Dae‐Ok; Shim, Ki-Hwan; Choi, Sung‐Gil; Heo, Ho Jin

doi:10.11002/kjfp.2011.18.1.124

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Additionally, sinapic acid, a predominant phenolic detected in C. papaya ‘Khaekdum’ [ 15 ], expressed a neuroprotective effect on a Aβ 1–42 induced AD mouse [ 29 ]. A protective effect against H 2 O 2 -induced neurotoxicity was also reported in guava [ 20 ]. Gallic acid, a predominant phenolic in P. guajava ‘Kimju’, and quercetin in P. guajava ‘Keenok’ were able to inhibit ChEs [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 73%

“…Interestingly, aqueous ethanolic extract of pineapple ( Ananas comosus , Prima) has previously been reported to enhance cognitive function in scopolamine-induced mice [ 18 ], while a miniature review on the health benefits of papaya ( Carica papaya , unknown variety) summarized its role in oxidative stress-induced AD [ 19 ]. A protective effect against H 2 O 2 -induced neurotoxicity of hot water extracted guava (Psidium guajava , unknown variety) has also been reported [ 20 ]. Additionally, ethanolic extract of durian ( Durio zibethinus ) cultivar ‘Monthong’ was able to inhibit neurotransmitter degrading acetylcholinesterase and Aβ aggregation and also had an enhanced neuroprotective effect against Aβ [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis

et al. 2022

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Alzheimer’s disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety. In this study, ten tropical fruits including Ananas comosus ‘Phulae’, Ananas comosus ‘Pattavia’, Carica papaya ‘Khaekdum’, Carica papaya ‘Khaeknuan’, Durio zibethinus ‘Monthong’, Durio zibethinus ‘Chanee’, Psidium guajava ‘Kimju’, Psidium guajava ‘Keenok’, Mangifera indica ‘Kaew’ and Mangifera indica ‘Namdokmai’ were screened for their inhibitory activities against the key enzymes, cholinesterases and β-secretase (BACE-1), involved in AD pathogenesis. The top three fruit extracts with promising in vitro anti-AD activities were further investigated using rat pheochromocytoma PC-12 neuronal cell line and Drosophila AD model. Data showed that M. indica ‘Kaew’, M. indica ‘Namdokmai’ and P. guajava ‘Kimju’ reduced Aβ1–42-mediated neurotoxicity by promoting glutathione-dependent enzymes, while M. indica ‘Namdokmai’ limited Aβ1–42 peptide formation via BACE-1 inhibition and amended locomotory behavior of the Drosophila AD model. Results indicated the potential anti-AD properties of tropical fruits, particularly M. indica ‘Namdokmai’ in the prevention of Aβ1–42-mediated neurotoxicity and as a BACE-1 blocker.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis

et al. 2022

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“…This may be the cause of the excellent antioxidant efficacy of BHM in this study, as it is enriched with polyphenols and flavonoids. and Shim (2000). However, the result deviates from the slightly low DPPH radical scavenging activity of BSE, soybean sprouts extract; HDE, 1.5% Hovenia dulcis Thunb.…”

Section: Tpc and Tfc In Bhmmentioning

confidence: 83%

Physicochemical properties and physiological activity of bean sprouts extract containing Hovenia dulcis Thunb concentrates

Heo,

Park,

Min

et al. 2023

Korean J. Food Preserv.

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Reactive oxygen species are the byproducts of metabolic processes in the body, However, excessive amount may cause side effects such as cancer. Therefore, to reduce the production of these species, but their long-term administration at high doses may induce side effects. Hence, natural materials with antioxidant activities are attracting attention. Two of these natural materials are soybean sprouts and Hovenia dulcis Thunb. fruits, but few studies have evaluated the effects of their combination. Thus, we prepared a soybean sprout extract containing 1.5% H. dulcis Thunb. fruit concentrate (BHM) to develop a functional food material derived from natural products and then confirmed its physicochemical properties and physiological activity. Among the organic acids detected in BHM, malic acid exhibited the highest content of 1,451.03 ppm, and the main free sugars were glucose (645.48 ppm) and fructose (738.11 ppm). Taurine was the most abundant free amino acid at a concentration of 11.95 ppm, followed by those of arginine (10.97 ppm) and glutamic acid (10.16 ppm). Analyses of the mineral components revealed large amounts of Zn and Fe in BHM, and the respective total polyphenol and flavonoid contents in BHM were 957.16 and 601.93 ppm. The DPPH radical and H2O2 scavenging activities and reducing power indicated excellent antioxidant efficacy compared to the positive controls. Furthermore, blood alcohol and acetaldehyde concentrations were measured to confirm the hangover-relieving effects of BHM, with both significantly decreased (p<0.05). BHM displays potential for development as a functional food, and the results of this study may be used as basic data in further research.

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“…Em um ensaio de viabilidade de células nuronias usando o brometo de 3-(4,5-dimetil-tiazol-2-il) -2,5-difeniltetrazólio (MTT), os extratos obtidos com água quente de frutas e folhas de P. guajava protegeram contra a neurotoxicidade induzida por radicias livres produzidos por H2O2. Estes dados in vitro sugerem que extratos aquosos e folhas da goiabeira, ricos em compostos fenólicos que são antioxidantes, podem ser úteis no tratamento de doenças neurodegenerativas como a doença de Alzheimer (Jeong et al, 2011).…”

Section: Introductionunclassified

Potencial da planta Psidium guajava L. contra a doença de Alzheimer pela reversão do déficit de memória induzido por escopolamina

Silva

Santos²,

Costa³

et al. 2022

RSD

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A Doença de Alzheimer (DA) representa a principal causa de demência em todo o mundo. Exemplos de abordagens promissoras na investigação de produtos contra a DA é a avaliação in vitro da inibição da enzima acetilcolinesterase e da proteção contra o stress oxidativo induzido em células neuronais por H2O2, já utilizadas em extratos de P. guajava. Este trabalho tem o objetivo de avaliar in vivo a eficácia do extrato da folha de P. guajava na reversão do déficit de memória de trabalho induzida por escopolamina. Para tanto foram utilizados 33 camundongos Swiss, machos, albinos (35-45g). Animais controle (Ctr) receberam salina, o déficit de memória foi induzido por escopolamina 5 mg/kg (Esc). O extrato etanólico da folha de P. guajava (EFPG) foi diluído em etanol 5% em salina e administrado em duas diferentes concentrações (EFPG 1 e 10 mg/kg). A administração de escopolamina promoveu o déficit na memória de trabalho (alternações espontâneas: Ctr: 69,2 ± 4,9; Esc: 51,8 ± 5,0). Na dose de 10 mg/kg do EEPG, observou-se um bloqueio parcial do déficit de memória (Esc + EEPG 10: 62,6 ± 3,1). Não foram observadas alterações estatisticamente significativas entre os grupos quando se avaliou o número de entradas nos braços durante o teste (Eventos: Ctr: 22,9±2,7; Esc: 28,1±2,9; Esc + EEPG 1: 25,2±3,1; Esc + EEPG 10: 23,6±2,6). Como para o extrato da folha de P. guajava foi relatada atividade anticolinesterásica in vitro, o presente trabalho contribui para adicionar evidências do seu potencial terapêutico para o tratamento da Doença de Alzheimer.

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Neuronal Cell Protective Effects of Hot Water Extracts from Guava (Psidium guajava L.) Fruit and Leaf

Cited by 7 publications

References 21 publications

Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis

Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis

Physicochemical properties and physiological activity of bean sprouts extract containing Hovenia dulcis Thunb concentrates

Potencial da planta Psidium guajava L. contra a doença de Alzheimer pela reversão do déficit de memória induzido por escopolamina

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