2019
DOI: 10.1016/j.conb.2018.12.012
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Neuronal cell types in the fly: single-cell anatomy meets single-cell genomics

Abstract: Highlights • A neuronal type is a testable hypothesis: similarity indicates functional equivalency. • Image registration together with morphology algorithms define types across datasets. • Single-cell transcriptomics produce cell-atlases with consistent clusters. • Specific genetic lines bridge transcriptomic clusters to morphological types. • Genetic driver lines, connectomics and transcriptomics make a full Drosophila neuronal parts list imminent.

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Cited by 70 publications
(77 citation statements)
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“…We and others observe a steady decline in number of many cell types in the adult brain with age 18,79 . The continual loss of cells in the ageing brain may be analogous to wounding, which induces polyploidisation or compensatory cellular hypertrophy in other Drosophila tissues 32,33,54 31,84 .…”
Section: Is Polyploidy Protective?supporting
confidence: 52%
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“…We and others observe a steady decline in number of many cell types in the adult brain with age 18,79 . The continual loss of cells in the ageing brain may be analogous to wounding, which induces polyploidisation or compensatory cellular hypertrophy in other Drosophila tissues 32,33,54 31,84 .…”
Section: Is Polyploidy Protective?supporting
confidence: 52%
“…One possibility is that polyploidy in neurons or glia may allow cells to compensate for cell loss while maintaining established cell-cell contacts. The compound eye and optic lobes of Drosophila contain ~750-800 ommatidial 'units' that form a highly organised and crystalline structure 5,78,79 . Numerically and topographically matched cells in the medulla cortex of the OL receive inputs from the lamina which in turn receives inputs from the retina 78,79 .…”
Section: What Is the Function Of Polyploidisation In The Brain?mentioning
confidence: 99%
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“…We leveraged a recent synaptic-resolution whole-brain serial section transmission electron micrograph (EM) volume [21] of an adult Drosophila brain to take a full inventory of 346 projection neurons (PNs) that relay olfactory information from the AL to higher brain centres ( Figure 1C, S1A and Supplemental Data). Because the fly brain is highly morphologically stereotyped, our high-resolution reconstructions should serve as holotypes for identifying these important cells in other datasets [57].…”
Section: Numerical Stereotypy Among Olfactory Projection Neuronsmentioning
confidence: 99%