Neuronal differentiation and developmental characteristics in the dentate gyrus of staggerer mutant mice

Yi, Sun Shin; Hwang, In Koo; Shin, Jae Hoon; Baek, Sung Hee; Yoon, Yeo Sung; Seong, Je Kyung

doi:10.5483/bmbrep.2010.43.2.122

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…Despite the Rora sg mutation being described as a recessive mutation, heterozygous mutants, at 12 months, have undergone degeneration of 35% of Purkinje cells, 35% of granule cells and 40% of inferior olive neurons [ 112 ]. The Rora sg mutation also influences neuronal differentiation and development in the hippocampal dentate gyrus as shown by a lower expression of doublecortin and NeuN [ 113 ].…”

Section: Reviewmentioning

confidence: 99%

From mice to men: lessons from mutant ataxic mice

Cendelín

2014

cerebellum ataxias

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Ataxic mutant mice can be used to represent models of cerebellar degenerative disorders. They serve for investigation of cerebellar function, pathogenesis of degenerative processes as well as of therapeutic approaches. Lurcher, Hot-foot, Purkinje cell degeneration, Nervous, Staggerer, Weaver, Reeler, and Scrambler mouse models and mouse models of SCA1, SCA2, SCA3, SCA6, SCA7, SCA23, DRPLA, Niemann-Pick disease and Friedreich ataxia are reviewed with special regard to cerebellar pathology, pathogenesis, functional changes and possible therapeutic influences, if any. Finally, benefits and limitations of mouse models are discussed.

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Section: Reviewmentioning

confidence: 99%

From mice to men: lessons from mutant ataxic mice

Cendelín

2014

cerebellum ataxias

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“…DCX is a microtubule-associated protein expressed in migrating neuroblasts or immature neurons (Brown et al 2003;Yi et al 2010;Nam et al 2014). Above all, the number of DCX-immunoreactive neuroblast and immature neuron was significantly decreased in the Hes6 knockout group compared to age-matched wild-type littermates.…”

Section: Discussionmentioning

confidence: 95%

Hairy and Enhancer of Split 6 (Hes6) Deficiency in Mouse Impairs Neuroblast Differentiation in Dentate Gyrus Without Affecting Cell Proliferation and Integration into Mature Neurons

Nam

Kim

et al. 2015

Cell Mol Neurobiol

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Hes6 is a member of the hairy-enhancer of split homolog (Hes) family of transcription factors and interacts with other Hes family genes. During development, Hes genes are expressed in neural stem cells and progenitor cells. However, the role of Hes6 in adult hippocampal neurogenesis remains unclear. We therefore investigated the effects of Hes6 on adult hippocampal neurogenesis, by comparing Hes6 knockout and wild-type mice. To this end, we immunostained for markers of neural stem cells and progenitor cells (nestin), proliferating cells (Ki67), post-mitotic neuroblasts and immature neurons (doublecortin, DCX), mature neuronal cells (NeuN), and astrocyte (S100β). We also injected 5-bromo-2'-deoxyuridine (BrdU) to trace the fate of mitotic cells. Nestin- and Ki67-positive proliferating cells did now show any significant differences between wild and knockout groups. Hes6 knockout negatively affects neuroblast differentiation based on DCX immunohistochemistry. On the contrary, the ratio of the BrdU and NeuN double-positive cells did not show any significance, even though it was slightly higher in the knockout group. These results suggest that Hes6 is involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons.

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“…Immunohistochemical staining was conducted as described in our previous study (S. S. Yi et al., ). Immunohistochemistry staining was performed for each group under the same conditions in order to examine whether the degree of immunohistochemical staining was accurate.…”

Section: Methodsmentioning

confidence: 99%

Chronic Oral Administration of Tenebrio molitor Extract Exhibits Inhibitory Effect on Glucocorticoid Receptor Overexpression in the Hippocampus of Ovariectomy‐Induced Estrogen Deficient Mice

Kim

Baek

Lee

et al. 2019

Journal of Food Science

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It has been reported that estrogen deficiency in female disrupts systemic endocrinologic regulatory mechanisms, finally leading to osteoporotic condition. Estrogen deficiency also down‐regulates brain functions due to its deficits of its original roles in a number of neurological events. Therefore, it is necessary to find alternative materials that can prevent osteoporotic condition and maintain normal brain functions to correct such hormone deficiency. In the present study, we found that novel compounds originated from larvae of Tenebrio molitor (TM) possessed anti‐osteoporotic effect. They could also prevent abnormal progressive brain function by deaccelerating enhanced HPA‐axis negative feedback while maintaining neurogenesis in hippocampus. We daily administered TM to ovariectomized (OVX) ddY mice for 4 weeks and then performed histological and hormonal evaluations for its anti‐osteoporotic effects. In addition, we investigated glucocorticoid receptor (GR) expression and neuroblast expression (DCX) in the hippocampal dentate gyrus morphologically by immunohistochemistry analysis. According to our results, TM has anti‐osteoporotic effects. It also tends to bring interfered brain environment back to normal condition. These results suggest that TM might have anti‐osteoporosis effect and enhancing effects on enrichment of environment in brain by being antidestroyed hormonal deficiency simultaneously. This is the first study to report that TM can be used as source of bioactive substance to prevent decreased neurogenesis and impaired HPA axis driven by high GR expression in the hippocampus in hormonal deficient female animals. Practical Application Anti‐osteoporosis effect and stress resistance due to improved brain function caused by the ingestion of Tenebrio molitor extract were observed in postmenopausal women. T. molitor is available as a nutritional supplement for bone and brain health, which menopausal women need most.

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Neuronal differentiation and developmental characteristics in the dentate gyrus of staggerer mutant mice

Cited by 6 publications

References 12 publications

From mice to men: lessons from mutant ataxic mice

From mice to men: lessons from mutant ataxic mice

Hairy and Enhancer of Split 6 (Hes6) Deficiency in Mouse Impairs Neuroblast Differentiation in Dentate Gyrus Without Affecting Cell Proliferation and Integration into Mature Neurons

Chronic Oral Administration of Tenebrio molitor Extract Exhibits Inhibitory Effect on Glucocorticoid Receptor Overexpression in the Hippocampus of Ovariectomy‐Induced Estrogen Deficient Mice

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