Neuronal network-based biomimetic chip for long-term detection of olfactory dysfunction model in early-stage Alzheimer's disease

Liu, Mengxue; Chen, Changming; Gao, Keqiang; Qin, Chunlian; Yuan, Qunchen; Zhang, Hong; Zhuang, Liujing; Wang, Ping

doi:10.1016/j.bios.2022.114619

Cited by 3 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[123] A𝛽 oligomer-induced AD chips can also be used for spatial firing pattern mapping and cross-correlation between channels to verify the degradation mechanism of neural network connections. [124] Additionally, reported AD models based on the microfluidic chip were used to understand abnormal protein transport characterization, [125] and analyze the local mechanism of A𝛽-induced neurotoxicity in neurons, [126] early AD olfactory dysfunction, [127] and the responsive movement of microglia to different types of A𝛽. [128] The BBB/neurovascular unit chip also contributes more possibilities in AD research, such as revealing the causal effect between the increase in BBB permeability and the pathogenesis of AD [129,130] and screening new drugs for AD.…”

Section: Neurodegenerative Diseasementioning

confidence: 99%

Microfluidic Brain‐on‐a‐Chip: From Key Technology to System Integration and Application

Wang,

Zhang,

et al. 2023

Small

View full text Add to dashboard Cite

As an ideal in vitro model, brain‐on‐chip (BoC) is an important tool to comprehensively elucidate brain characteristics. However, the in vitro model for the definition scope of BoC has not been universally recognized. In this review, BoC is divided into brain cells‐on‐a‐ chip, brain slices‐on‐a‐chip, and brain organoids‐on‐a‐chip according to the type of culture on the chip. Although these three microfluidic BoCs are constructed in different ways, they all use microfluidic chips as carrier tools. This method can better meet the needs of maintaining high culture activity on a chip for a long time. Moreover, BoC has successfully integrated cell biology, the biological material platform technology of microenvironment on a chip, manufacturing technology, online detection technology on a chip, and so on, enabling the chip to present structural diversity and high compatibility to meet different experimental needs and expand the scope of applications. Here, the relevant core technologies, challenges, and future development trends of BoC are summarized.

show abstract