Neuronal nitric oxide synthase activity mediates Lycium barbarum polysaccharides-enhanced sexual performance without stimulating noncontact erection in rats

Huang, Andy C.; Wu, Jia-Min; Chang, Yu-Ting; Dubey, Navneet Kumar; Chiu, Allen W.; Yeh, Chien-Yu; Tsai, Tung Hu; Yeh, Kuei-Ying

doi:10.1007/s00213-018-5141-z

Cited by 1 publication

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These compounds include EGb 761 (a Ginkgo biloba extract), ginsenoside Rg1 (isolated from Panax ginseng) and Lycium Barbarum Polysaccharide, obtained by the Lycium Barbarum berries extensively used in Chinese medicine, and are used as food supplements. In rats these compounds have been found able to improve non-contact erections and sexual behavior, sometimes accompanied by increases in NO synthase expression in the hypothalamus, the medial preoptic area and the spinal cord [ 205 , 206 , 207 ]. However, the most widely used food supplement by men seeking natural treatment and/or self-medication for erectile dysfunction is l -arginine, the physiological NO synthase substrate.…”

Section: Can Central No Have a Role In Strategies Aimed To Improve Erectile Function And Sexual Behavior In Humans?mentioning

confidence: 99%

Erectile Function and Sexual Behavior: A Review of the Role of Nitric Oxide in the Central Nervous System

Melis

Argiolas

2021

Biomolecules

View full text Add to dashboard Cite

Nitric oxide (NO), the neuromodulator/neurotransmitter formed from l-arginine by neuronal, endothelial and inducible NO synthases, is involved in numerous functions across the body, from the control of arterial blood pressure to penile erection, and at central level from energy homeostasis regulation to memory, learning and sexual behavior. The aim of this work is to review earlier studies showing that NO plays a role in erectile function and sexual behavior in the hypothalamus and its paraventricular nucleus and the medial preoptic area, and integrate these findings with those of recent studies on this matter. This revisitation shows that NO influences erectile function and sexual behavior in males and females by acting not only in the paraventricular nucleus and medial preoptic area but also in extrahypothalamic brain areas, often with different mechanisms. Most importantly, since these areas are strictly interconnected with the paraventricular nucleus and medial preoptic area, send to and receive neural projections from the spinal cord, in which sexual communication between brain and genital apparatus takes place, this review reveals that central NO participates in concert with neurotransmitters/neuropeptides to a neural circuit controlling both the consummatory (penile erection, copulation, lordosis) and appetitive components (sexual motivation, arousal, reward) of sexual behavior.

show abstract

Section: Can Central No Have a Role In Strategies Aimed To Improve Erectile Function And Sexual Behavior In Humans?mentioning

confidence: 99%

Erectile Function and Sexual Behavior: A Review of the Role of Nitric Oxide in the Central Nervous System

Melis

Argiolas

2021

Biomolecules

View full text Add to dashboard Cite

show abstract

Neuronal nitric oxide synthase activity mediates Lycium barbarum polysaccharides-enhanced sexual performance without stimulating noncontact erection in rats

Cited by 1 publication

References 56 publications

Erectile Function and Sexual Behavior: A Review of the Role of Nitric Oxide in the Central Nervous System

Erectile Function and Sexual Behavior: A Review of the Role of Nitric Oxide in the Central Nervous System

Contact Info

Product

Resources

About