Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study

Vecchio, Fabrizio; Quaranta, Davide; Miraglia, Francesca; Pappalettera, Chiara; Iorio, Riccardo Di; L’Abbate, Federica; Cotelli, Maria; Marra, Camillo; Rossini, Paolo Maria

doi:10.1007/s11357-021-00508-w

Cited by 20 publications

(29 citation statements)

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“…Understanding these sex differences in pathophysiology may aid in the development of sex-specific precision medicine to manipulate hippocampal-precuneus cortex and hippocampal-brainstem connectivity to decrease the progression of MCI to AD. Our findings provide the rationale for sex-specific interventions such as cognitive training ( Hardcastle et al, 2022 ) and neuro-navigation guided, targeted non-invasive brain stimulation ( Mackenbach et al, 2020 ; Yang et al, 2021 ) or their combination ( Vecchio et al, 2022 ).…”

Section: Discussionmentioning

confidence: 85%

Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment

Williamson

Yabluchanskiy

Mukli

et al. 2022

Front. Aging Neurosci.

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Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer’s Disease (AD). Prior research shows that females are more impacted by MCI than males. On average females have a greater incidence rate of any dementia and current evidence suggests that they suffer greater cognitive deterioration than males in the same disease stage. Recent research has linked these sex differences to neuroimaging markers of brain pathology, such as hippocampal volumes. Specifically, the rate of hippocampal atrophy affects the progression of AD in females more than males. This study was designed to extend our understanding of the sex-related differences in the brain of participants with MCI. Specifically, we investigated the difference in the hippocampal connectivity to different areas of the brain. The Resting State fMRI and T2 MRI of cognitively normal individuals (n = 40, female = 20) and individuals with MCI (n = 40, female = 20) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analyzed using the Functional Connectivity Toolbox (CONN). Our results demonstrate that connectivity of hippocampus to the precuneus cortex and brain stem was significantly stronger in males than in females. These results improve our current understanding of the role of hippocampus-precuneus cortex and hippocampus-brainstem connectivity in sex differences in MCI. Understanding the contribution of impaired functional connectivity sex differences may aid in the development of sex specific precision medicine to manipulate hippocampal-precuneus cortex and hippocampal-brainstem connectivity to decrease the progression of MCI to AD.

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Section: Discussionmentioning

confidence: 85%

Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment

Williamson

Yabluchanskiy

Mukli

et al. 2022

Front. Aging Neurosci.

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“…A study by Turriziani et al (2019) used 1 Hz, and the other 6 studies used 10 Hz ( Rabey et al, 2013 ; Leocani et al, 2020 ; Padala et al, 2020 ; Jia et al, 2021 ; Vecchio et al, 2022 ). The dorsolateral prefrontal cortex (DLPFC) was selected as the stimulation site in the majority of studies (10/14) ( Cotelli et al, 2011 ; Ahmed et al, 2012 ; Rabey et al, 2013 ; Wu et al, 2015 ; Turriziani et al, 2019 ; Zhang et al, 2019 ; Bagattini et al, 2020 ; Padala et al, 2020 ; Li et al, 2021 ; Vecchio et al, 2022 ). Rabey et al (2013) and Vecchio et al (2022) stimulated Broca, Wernicke, L/R-DLPFC, and L/R pSAC.…”

Section: Resultsmentioning

confidence: 99%

“…The dorsolateral prefrontal cortex (DLPFC) was selected as the stimulation site in the majority of studies (10/14) ( Cotelli et al, 2011 ; Ahmed et al, 2012 ; Rabey et al, 2013 ; Wu et al, 2015 ; Turriziani et al, 2019 ; Zhang et al, 2019 ; Bagattini et al, 2020 ; Padala et al, 2020 ; Li et al, 2021 ; Vecchio et al, 2022 ). Rabey et al (2013) and Vecchio et al (2022) stimulated Broca, Wernicke, L/R-DLPFC, and L/R pSAC. Zhao et al (2017) stimulated four parietal P3/P4 and posterior temporal T5/T6.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies assessed the impact of rTMS on global cognitive functions, namely, the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Addenbrooke’s Cognitive Examination III (ACE-III) and the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Among these studies, 3 used the MMSE and ADAS-cog scales to assess patients’ global cognitive status ( Zhao et al, 2017 ; Zhang et al, 2019 ; Li et al, 2021 ), 6 studies counted MMSE results ( Cotelli et al, 2011 ; Ahmed et al, 2012 ; Koch et al, 2018 ; Bagattini et al, 2020 ; Padala et al, 2020 ; Jia et al, 2021 ), and 4 studies counted ADAS-cog results ( Rabey et al, 2013 ; Wu et al, 2015 ; Leocani et al, 2020 ; Vecchio et al, 2022 ). The above findings showed that rTMS significantly improved global cognitive functions (measured by MMSE or ADAS-Cog) in AD patients (SMD = 0.34,95% CI, 0.16 to 0.52, p = 0.0002, I 2 = 0%, Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

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The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysis

Wei

Liang

et al. 2022

Front. Aging Neurosci.

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BackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is widely used to treat Alzheimer’s Disease. However, the effect of rTMS is still controversial. The purpose of the present study is to evaluate the effectiveness of rTMS on cognitive performance of AD patients.MethodsWe systematically searched relevant literatures in four major databases - PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials [Central] before 28th April 2022. Both randomized controlled trials and cross-section studies that compared the therapeutic effect of rTMS with blank control or sham stimuli were included.ResultsA total of 14 studies involving 513 AD patients were finally included for meta-analysis. It was found that rTMS significantly improved global cognitive function (SMD = 0.24, 95%CI, 0.12 to 0.36, P = 0.0001) and daily living ability (IADL: SMD = 0.64, 95%CI, 0.21to 1.08, P = 0.004) in patients with AD, but did not show improvement in language, memory, executive ability, and mood. In further analyses, rTMS at 10 Hz, on a single target with 20 sessions of treatment was shown to produce a positive effect. In addition, improvement in cognitive functions lasted for at least 6 weeks (SMD = 0.67, 95%CI, 0.05 to 1.30,P = 0.04).ConclusionrTMS can improve the global cognition and daily living ability of AD patients. In addition, attention should be paid to the safety of rTMS in AD patients with seizures. Given the relatively small sample size, our results should be interpreted with caution.

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“…Recent studies have investigated the effect of this dual stimulation of rTMS-COG in order to evaluate possible improvements and long-term effects. In particular, a recent study [ 5 ] analyzed neuropsychological and neurophysiological data, derived from electroencephalography (EEG), to evaluate the effects of a rTMS-COG treatment in Alzheimer patients. The study was designed a randomized, double-blind, sham-controlled trial to evaluate efficacy of rTMS on 6 brain regions obtained by an individual MRI combined with COG related to brain areas to stimulate (i.e.…”

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confidence: 99%

Cognitive training and neuromodulation for Alzheimer treatment

Vecchio

2022

Aging

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Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study

Cited by 20 publications

References 54 publications

Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment

Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment

The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysis

Cognitive training and neuromodulation for Alzheimer treatment

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