Neuropathies associées à une IgM monoclonale anti-MAG

Pihan, M.; Decaux, Olivier; Marcorelles, Pascale; Bahon-Riedinger, I.; Lemercier, S.; Gainche-Salmon, A.; Doncker, Anne-Violaine

doi:10.1016/j.revmed.2012.05.009

Cited by 2 publications

(1 citation statement)

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“…There is emerging evidence that humoral response may be involved in the pathogenesis and progression of different neurodegenerative disorders, including Parkinson's disease (PD) [1,2,3]. Autoantibodies specific to different self-antigens have been found in a variety of neurological disorders [4,5,6,7] as well as in PD [1,3,8]. Nevertheless, assessment of the role of antibodies directed against the most important self-antigen in PD, alpha-synuclein, has produced confounding results.…”

Section: Introductionmentioning

confidence: 99%

Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s disease

Papuć

Wilczyńska

Rejdak

2016

Ann Agric Environ Med.

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Identification of disease-specific diagnostic and prognostic biomarkers which would enable early detection and follow-up of Parkinson's disease (PD) is a crucial problem. Recently, we confirmed the presence of adaptive immune response against different glial-derived antigens in PD. Objective. The aim of the study was to assess humoral response against myelin-associated glycoprotein (MAG) on a larger group of PD patients. IgM autoantibodies against MAG were measured by an ELISA system in 66 PD patients and 66 control subjects. Results. The study confirmed a significantly increased production of anti-MAG IgM antibodies in parkinsonian patients (p<0.05). No correlations were found between anti-MAG IgM antibody titers and disease severity measured on the Hoehn-Yahr scale, MMSE or age of PD onset (p>0.05). The results provide evidence for activation of humoral response against MAG in PD patients, but argue against the utility of anti-MAG antibodies as biomarkers of disease severity. The results additionally indicate the potential protective role of autoimmunity in maintaining the body's homeostasis, which may involve the clearance of abnormal proteins. Further studies are necessary to confirm the role of anti-MAG antibodies as biomarkers of PD, especially in relation to other neurodegenerative disorders.

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