Neuropathological changes in the rat brain cortex in vitro: effects of kainic acid and of ion substitutions

Glutamate, Cell Death and Memory

“…Sampling of aliquots and measurements of LDH activity were performed as described by Frandsen and Schousboe (1987). It should be noted, however, that several investigators have reported that neurotoxicity induced by glutamate or other EAAs in different brain tissues or cell preparations is dependent on extracellular Ca++ Berdichevsky et al '1987;). On the other hand, the glutamate-induced increase in [Ca++]i directly related to Ca++ influx does not appear to be of primary importance.…”