Neuropathy and motor neuron syndromes associated with plasma cell disease

Patten, Bernard M.

doi:10.1111/j.1600-0404.1984.tb00802.x

Cited by 18 publications

(2 citation statements)

References 53 publications

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“…The association between MND and LPD could be coincidental, but LPD seems to be disproportionately frequent in patients with MND compared to the population in general [5]. Despite an initial report suggesting that major improvements occurred sometimes coincidentally with reductions in paraprotein levels using prednisone, cyclophosphamide, chlorambucil and plasma exchange treatments even in some patients who had the clinical appearance of ALS [6], most of the subsequent literature argues against this, with less than successful trials using various immunomodulatory agents and plasma exchange. Gordon et al .…”

Section: Discussionmentioning

confidence: 99%

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Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature

Rison

Beydoun

2010

J Med Case Reports

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IntroductionAmyotrophic lateral sclerosis (the most common form of motor neuron disease) is a progressive and devastating disease involving both lower and upper motor neurons, typically following a relentless path towards death. Given the gravity of this diagnosis, all efforts must be made by the clinician to exclude alternative and more treatable entities. Frequent serology testing involves searching for treatable disorders, including vitamin B12 deficiency, parathyroid anomalies, and monoclonal gammopathies.Case presentationWe present the case of a 78-year-old Caucasian man with all three of the aforementioned commonly searched for disorders during an investigation for amyotrophic lateral sclerosis.ConclusionsThe clinical utility of these common tests and what they ultimately mean in patients with amyotrophic lateral sclerosis is discussed, along with a review of the literature.

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Section: Discussionmentioning

confidence: 99%

“…In a literature review, Latov [10] found 19 cases of MND and monoclonal gammopathy. Patten [6] described four patients with ALS and IgG monoclonal gammopathy. Shy et al .…”

Section: Discussionmentioning

confidence: 99%

Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature

Rison

Beydoun

2010

J Med Case Reports

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Amyotrophic Lateral Sclerosis

Mitsumoto

Hanson²,

Chad³

1988

Arch Neurol

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This chapter was originally intended to cover both amyotrophic lateral sclerosis (ALS) and multiple sclerosis, but we will concentrate on ALS. There are nonetheless several reports from the literature that ionotropic glutamate receptor antagonists have beneficial effects in animal models of multiple sclerosis (1,7,14,58,71,109) and this could develop into a very promising therapeutic area in the future. The interested reader is referred to the following review (59). However, the evidence for involvement of disturbances in the glutamatergic system in ALS is already convincing and has led to the use of the glutamate release inhibitor riluzole in the treatment of this disease. As such, we felt that a book on the therapeutic potential of ionotropic glutamate receptor antagonists and modulators would be incomplete without a chapter on this disease. RATIONALEALS, commonly called Lou Gehrig's disease, is a devastating neurological disorder characterized by selective upper and lower somatic, but not autonomic, motor neurone degeneration leading to paralysis and eventually death. The diagnosis of ALS requires the presence of both upper and lower motor neurone degeneration and progressive motor dysfunction. ALS occurs in 1 to 2.5 cases per 100,000 population, affects more men than women, and is most commonly diagnosed in middle age. Other functions such as intellectual abilities and sensory perception are preserved. At advanced stages patients become completely disabled, often requiring ventilatory support and feeding by gas-

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Amyotrophic lateral sclerosis: An unconventional autoimmune disease?

Drachman¹,

Kuncl²

1989

Annals of Neurology

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The possibility of an autoimmune mechanism of pathogenesis in amyotrophic lateral sclerosis has long been considered, but the evidence to support a conventional autoimmune process, reviewed here, is inconclusive. However, antibodies that react in vitro with gangliosides have recently been found in sera of a large majority of patients with classical amyotrophic lateral sclerosis and other motor neuron syndromes. A working hypothesis is proposed, suggesting how antibodies might be related to the disease process. The hypothesis attempts to account for (1) a pathogenic role of antibodies directed against the carbohydrate components of glycolipids, (2) the selectivity of the process for motor neurons, (3) an antibody-mediated mechanism that could result in apparently degenerative neuropathological changes without signs of inflammation, and (4) a type of autoimmune response that is extremely difficult to suppress by conventional means. Although the evidence for this hypothesis is by no means complete, its critical features are all testable.

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Neuropathy and motor neuron syndromes associated with plasma cell disease

Cited by 18 publications

References 53 publications

Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature

Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature

Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis: An unconventional autoimmune disease?

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