Neuropathy and primary headaches affect different subgroups of inflammatory bowel disease patients

Leitão, Antônio Miguel Furtado; Ribeiro, Howard Lopes; Araújo, Davi Farias de; Braga, Lúcia Libanez Bessa Campelo; Souza, Marcellus H.; Barbosa, Alzira M. C.; Júnior, Antônio Baldin; Gondim, Francisco de Assis Aquino

doi:10.1007/s10072-020-04596-y

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…Psychiatric disease by itself affected close to 30% of the patients (32%). As previously reported in the medical literature, headaches, especially migraine are common in patients with IBD (10) . Other common neurological disorders included facial palsy, epilepsy, syncope, hearing loss and a wide variety of peripheral neuropathies (4) .…”

Section: Discussionsupporting

confidence: 61%

A Medical and Neuropsychiatric Management Survey in a Brazilian Cohort of Patients With Inflammatory Bowel Disease (Ibd)

LEITÃO,

TABATINGA NETO,

SOUZA

et al. 2024

Arq. Gastroenterol.

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Inflammatory bowel disease (IBD) can be accompanied by several neurological disorders. Since 2004, we started a Brazilian cohort to assess neuropsychiatric complications in IBD patients. Changes in therapeutic strategy and differences in the prevalence and relevance of neuropsychiatric disorders have been reported in the literature. We conducted a short patient-reported survey about the medical management of IBD (with a special focus on neuropsychiatric management) and its complications. During the enrollment period (9/1/2021 to 8/31/2022), 279 patients with IBD answered the survey (128 patients with ulcerative colitis and 151 with Crohn’s disease). This is the first medical management survey aimed to verify the level of perception of IBD patients about their neuropsychiatric conditions. We found a high prevalence of neurologic (59%), psychiatric (32%), and neuropsychiatric co-morbidities (69%). There is a marked discrepancy between the findings of neurological disorders reported in our studies over the first 10 years of the cohort in comparison with the current perception/knowledge among the patients registered in the present management survey. Patients tend to have a better understanding of central rather than peripheral nerve conditions.

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Section: Discussionsupporting

confidence: 61%

A Medical and Neuropsychiatric Management Survey in a Brazilian Cohort of Patients With Inflammatory Bowel Disease (Ibd)

LEITÃO,

TABATINGA NETO,

SOUZA

et al. 2024

Arq. Gastroenterol.

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“…Four studies, mostly coming from big insurance data-bases with incredibly low migraine prevalence, have found no association (6)(7)(8)(9). The remaining seven (10)(11)(12)(13)(14)(15)(16) did find a numerical difference, but these differences were only significant in three of them (12)(13)(14). These three positive studies cannot be interpreted as definitive as either just used one question to diagnose migraine (14), the number of included cases was too low (n ¼ 80) (12) or the percentages found for prevalence of migraine in IBD patients and controls (41% and 21.3%, respectively) were too high (13).…”

Section: Introductionmentioning

confidence: 99%

Increased prevalence of migraine in women with inflammatory bowel disease: A cross-sectional study

Pascual-Mato,

Gárate,

de Prado-Tejerina

et al. 2024

Cephalalgia

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Background Some studies have suggested an association between migraine and inflammatory bowel disease. We determined migraine prevalence in a cohort of patients with inflammatory bowel disease. Methods Patients with inflammatory bowel disease aged 18–65 years were interviewed using an ad hoc headache questionnaire. Those who admitted a history of headache in the last year answered the three questions of the ID-Migraine questionnaire. Those who answered “yes” to the three of them were classified as “definite” and those who answered “yes” to two were classified as “probable” migraine. Results We interviewed 283 patients with inflammatory bowel disease. Of these, 176 (62.2%) had headache. Fifty-nine (20.8%; 95% CI 16.3–26.0%) met migraine criteria either definite (n = 33; 11.7%; 95% CI 8.2–16.0%) or probable (n = 26; 9.2%; 95% CI 6.1–13.2). When divided by gender, 12 men (9.6%; 95% CI 5.1–16.2%) and 47 women (29.8%; 95% CI 22.8–37.5%) met migraine criteria. The prevalence of migraine was increased in inflammatory bowel disease patients from the current cohort (20.8%) versus that reported for our general population for the same age group (12.6%; p < 0.0001). These differences remained significant in female inflammatory bowel disease patients (29.8% versus 17.2% in our general population; p < 0.0001), but not in males (9.6% in inflammatory bowel disease vs 8.0%; p = 0.30). Seventeen patients with inflammatory bowel disease (6.0%; 95% CI 3.54–9.44%) fulfilled chronic migraine criteria. There were no differences in migraine prevalence by inflammatory bowel disease subtypes. Conclusion Migraine prevalence, including chronic migraine, seems to be increased in patients with inflammatory bowel disease. The fact that this association was stronger for women suggests an influence of sex-related factors.

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Section: Introductionmentioning

confidence: 99%

“…Widely different numbers on the prevalence of neurological disorders in IBD have been reported, likely due to different inclusion criteria and ethnic characteristics [5][6][7][8][9][10][11][12]. Autoimmune diseases reported in IBD include peripheral neuropathy, myelopathy, multiple sclerosis (MS), optic neuritis and MG [5][6][7][8][9][10][11][12]. Here, we present the epidemiological, clinical and electrodiagnostic ndings of four IBD patients from our cohort who developed MG, and conducted a systematic literature review about the subject.…”

Section: Introductionmentioning

confidence: 99%

Increased Prevalence of Myasthenia Gravis in a Cohort of Patients with Inflammatory Bowel Disease

Leitão,

Gondim,

Thomas

et al. 2023

Preprint

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Background. Co-morbid auto-immune disorders may affect 0.2% of the population. We evaluated the association between myasthenia gravis and inflammatory bowel disease. Methods. We present the epidemiological, clinical and electrodiagnostic findings of one patient with ulcerative colitis and three with Crohn’s disease (from a Brazilian cohort of 606 patients) and co-morbid myasthenia gravis. Results.Mean age of onset of inflammatory bowel disease was 33.5+2.7, and patients are currently 45.8+7.3 years old. Two patients were acetylcholine receptor antibody positive, one anti-Muscle specific kinase positive and one seronegative. Three had abnormal repetitive nerve stimulation, all four had normal nerve conduction studies, abnormal skin wrinkling test and mild small fiber neuropathy. None had thymoma and/or accepted thymectomy. According to the Myasthenia Gravis Foundation classification, one was class V, one class IVb and two IIa. Myasthenia gravis diagnosis was masked by immunotherapy in all. The Prevalence ratio of having myasthenia gravis in inflammatory bowel disease patients in comparison with the proportion of myasthenia gravis among all patients seen in our center was 8.56 (P<0.0001, CI=3.1-23.5). Considering the lowest and highest prevalence of myasthenia gravis reported in the literature, the Prevalence ratio is 44.0 (P<0.0001, CI:16.3-118.4) and 26.4 (P<0.0001, CI: 9.8-70.6), respectively. Conclusions. Myasthenia gravis prevalence is higher in inflammatory bowel disease and may include muscle specific kinase positive disease (first report in the literature). In general, myasthenia gravis clinical course was not significantly modified by inflammatory bowel disease relapses and frequently overlaps with other autoimmune conditions and small fiber neuropathy.

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Neuropathy and primary headaches affect different subgroups of inflammatory bowel disease patients

Cited by 5 publications

References 26 publications

A Medical and Neuropsychiatric Management Survey in a Brazilian Cohort of Patients With Inflammatory Bowel Disease (Ibd)

A Medical and Neuropsychiatric Management Survey in a Brazilian Cohort of Patients With Inflammatory Bowel Disease (Ibd)

Increased prevalence of migraine in women with inflammatory bowel disease: A cross-sectional study

Increased Prevalence of Myasthenia Gravis in a Cohort of Patients with Inflammatory Bowel Disease

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