Neuropeptide-Y both improves and impairs delayed matching-to-sample performance in rats

Thomas, John R.; Ahlers, Stephen T.

doi:10.1016/0091-3057(91)90573-k

Cited by 10 publications

(5 citation statements)

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“…NPY induced dose-dependent biphasic responses in a DMTS test performed with mice, where i.c.v. pre-treatment with low doses (0.23-0.5 nmol/kg) or high doses (1-16 nmol/kg) of NPY, enhanced or impaired working memory, respectively (Thomas & Ahlers, 1991). The dosedependent differences could be explained by differential activation or differential anatomical location of the NPY receptor subtypes or NPY-induced proactive interference from previous trials as previously reported for this type of test (Dunnett et al, 1990).…”

Section: Discrimination Memorymentioning

confidence: 53%

“…In the DMTS task, subjects are required to employ short-term and working memory in order identify a previously encountered stimulus from a selection of comparable stimuli with variable delay intervals between familiarization and recognition sessions (Thomas & Ahlers, 1991;Kangas et al, 2011). NPY induced dose-dependent biphasic responses in a DMTS test performed with mice, where i.c.v.…”

Section: Discrimination Memorymentioning

confidence: 99%

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The role of NPY in learning and memory

2016

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Section: Discrimination Memorymentioning

confidence: 53%

Section: Discrimination Memorymentioning

confidence: 99%

The role of NPY in learning and memory

2016

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“…Fluctuations in circulating adrenal steroids during stress represent another important influence on prepro‐NPY mRNA expression in the hippocampus, particularly in the dentate gyrus (17, 57). Furthermore, the hippocampus has been implicated in learning and memory (14, 58), behaviour and emotion (59) and cardiovascular control (60), suggesting that these functions may be influenced by differences in the NPY response to restraint at the level of the hippocampus and dentate gyrus in SHR.…”

Section: Discussionmentioning

confidence: 99%

“…Central (intracerebroventricular; i.c.v.) administration of NPY in normotensive rats produces hypotension and bradycardia (11), increases feeding (12), depresses spontaneous locomotor activity (13) and modulates short‐term memory (14). Furthermore, NPY appears to have a closely associated modulatory relationship with neuroendocrine systems such as the hypothalamic‐pituitary‐adrenal (HPA) axis (15–17).…”

mentioning

confidence: 99%

The Effect of Acute and Chronic Restraint on the Central Expression of Prepro‐Neuropeptide Y mRNA in Normotensive and Hypertensive Rats

Sweerts

Jarrott

Lawrence

2001

J Neuroendocrinology

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Neuropeptide Y (NPY), one of the most abundant neuropeptides found in the central nervous system (CNS), has been implicated in the regulation of many autonomic functions, including cardiovascular control and the central stress response. The present study represents a detailed investigation of the effects of acute and chronic restraint stress on the expression of the mRNA encoding the NPY precursor, prepro-NPY, in the CNS of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) using in situ hybridization histochemistry. Basal (unstressed) levels of prepro-NPY mRNA expression were found to be significantly increased in the hypothalamic arcuate nucleus of SHR compared to WKY rats, with similar levels of prepro-NPY mRNA expression found in the remaining central nuclei. Following exposure to both acute and chronic restraint, significant changes in prepro-NPY mRNA expression were found in a variety of central regions in both strains, including the arcuate nucleus and hippocampus (both strains), medial amygdala and cortex (WKY only), and dentate gyrus, nucleus of the solitary tract and ventrolateral medulla (SHR only). A comparison of the temporal response to restraint revealed that significant differences between strains existed in regions such as the arcuate nucleus, hippocampus and dentate gyrus, providing further evidence that hypertensive rats apparently have an impaired neural stress response. The present study demonstrates that exposure to restraint results in significant changes in prepro-NPY mRNA expression in specific nuclei of both WKY and SHR that are components of not only the central circuitry regulating the stress response, but also the neural network modulating autonomic function.

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“…However, the role of NPY as a memory modulator is still controversial (Gøtzsche & Woldbye, 2016). Previous research showed that the NPYergic system participates in cognitive processes either improving or impairing short-and long-term memory, and these effects are claimed to be both dose-and brain region-specific (Bertocchi et al, 2021;Flood et al, 1987;Gøtzsche & Woldbye, 2016;Kornhuber & Zoicas, 2017Thomas & Ahlers, 1991). The CNS NPYergic system exerts its effects through Y 1-Y 6 receptors (Parker & Herzog, 1999;Xapelli et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal Neuropeptide Y₂receptor blockade improves spatial memory retrieval and modulates limbic brain metabolism

Méndez-Couz

González-Pardo

Árias

et al. 2021

Preprint

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IntroductionThe neuropeptide Y (NPY) is broadly distributed in the central nervous system (CNS), and it has been related to neuroprotective functions. NPY seems to be an important component to counteract brain damage and cognitive impairment mediated by drugs of abuse and neurodegenerative diseases, and both NPY and its Y2 receptor (Y2R) are highly expressed in the hippocampus, critical for learning and memory. We have recently demonstrated its influence on cognitive functions; however, the specific mechanism and involved brain regions where NPY modulates spatial memory by acting on Y2R remain unclear.MethodsHere, we examined the involvement of the hippocampal NPY Y2R in spatial memory and associated changes in brain metabolism by bilateral administration of the selective antagonist BIIE0246 into the rat dorsal hippocampus. To further evaluate the relationship between memory functions and neuronal activity, we analysed the regional expression of the mitochondrial enzyme cytochrome c oxidase (CCO) as an index of oxidative metabolic capacity in limbic and non-limbic brain regions.ResultsThe acute blockade of NPY Y2R significantly improved spatial memory recall in rats trained in the Morris water maze that matched metabolic activity changes in spatial memory processing regions. Specifically, CCO activity changes were found in the dentate gyrus of the dorsal hippocampus and CA1 subfield of the ventral hippocampus, the infralimbic region of the PFC and the mammillary bodies.ConclusionsThese findings suggest that the NPY hippocampal system, through its Y2R receptor, influences spatial memory recall (retrieval) and exerts control over patterns of brain activation that are relevant for associative learning, probably mediated by Y2R modulation of long-term potentiation and long-term depression.HighlightsUnder hippocampal Y2R antagonism, place preference memory retrieval is enhancedSpatial retrieval enhancement under Y2R blockade is correlated with changes in regional brain energy metabolismEnhanced retrieval associated CCO activity increases in the dorsal DG, while decreasing in the ventral CA1, IL cortex and mammillary bodiesY2R exert control over patterns of brain activation that are relevant for spatial memory expression

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Neuropeptide-Y both improves and impairs delayed matching-to-sample performance in rats

Cited by 10 publications

References 32 publications

The role of NPY in learning and memory

The role of NPY in learning and memory

The Effect of Acute and Chronic Restraint on the Central Expression of Prepro‐Neuropeptide Y mRNA in Normotensive and Hypertensive Rats

Hippocampal Neuropeptide Y₂receptor blockade improves spatial memory retrieval and modulates limbic brain metabolism

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Neuropeptide-Y both improves and impairs delayed matching-to-sample performance in rats

Cited by 10 publications

References 32 publications

The role of NPY in learning and memory

The role of NPY in learning and memory

The Effect of Acute and Chronic Restraint on the Central Expression of Prepro‐Neuropeptide Y mRNA in Normotensive and Hypertensive Rats

Hippocampal Neuropeptide Y2receptor blockade improves spatial memory retrieval and modulates limbic brain metabolism

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Hippocampal Neuropeptide Y₂receptor blockade improves spatial memory retrieval and modulates limbic brain metabolism