Neuropeptide Y expression in primary cutaneous melanoma

Tato, Berta Pérez; Juarranz, Ángeles; Nájera, Laura; Mihm, Martín C.; Fernandez, Philippe; Gilaberte, Yolanda; González, S.

doi:10.1111/jdv.13836

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…Nevertheless, in a study in which copy number variations of neuropeptide and receptor genes were investigated for multiple cancers, the expression of NPY and its receptors, Y1R , Y2R , and Y5R , were given negative prognostic Z-scores in cutaneous melanoma ( 110 ). Having negative prognostic scores in this study indicates that the expression of NPY and its receptors in cutaneous melanoma is associated with favorable survival outcomes for patients, which is in agreement with the findings from Pérez Tato and colleagues’ clinical study of NPY expression in primary cutaneous melanomas ( 86 ).…”

Section: Genetic Associations Of Npy With Skin Pathologysupporting

confidence: 91%

“…There was also a slight positive correlation between NPY expression and tumor cell proliferation. In a follow-up study, Perez Tato and colleagues evaluated 79 primary tumors and found that superficial spreading melanoma and lentigo maligna exhibit significantly higher levels of NPY expression in comparison to nodular melanoma ( 86 ). However, in contrast to Gilaberte et al these authors report low NPY expression associated with high proliferation, increased metastasis, high peritumoral mast cell density, and reduced patient survival, but no relationship between NPY expression and intratumoral lymphocyte infiltration.…”

Section: Expression Of Npy Protein In Skin Pathologymentioning

confidence: 99%

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Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology

et al. 2022

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Neuropeptide Y is widely distributed within the body and has long been implicated as a contributor to skin disease based on the correlative clinical data. However, until recently, there have been few empirical investigations to determine whether NPY has a pathophysiological role in the skin. Due to appearance-altering phenotypes of atopic dermatitis, psoriasis, and vitiligo, those suffering from these diseases often face multiple forms of negative social attention. This often results in psychological stress, which has been shown to exacerbate inflammatory skin diseases – creating a vicious cycle that perpetuates disease. This has been shown to drive severe depression, which has resulted in suicidal ideation being a comorbidity of these diseases. Herein, we review what is currently known about the associations of NPY with skin diseases and stress. We also review and provide educated guessing what the effects NPY can have in the skin. Inflammatory skin diseases can affect physical appearance to have significant, negative impacts on quality of life. No cure exists for these conditions, highlighting the need for identification of novel proteins/neuropetides, like NPY, that can be targeted therapeutically. This review sets the stage for future investigations into the role of NPY in skin biology and pathology to stimulate research on therapeutic targeting NPY signaling in order to combat inflammatory skin diseases.

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Section: Genetic Associations Of Npy With Skin Pathologysupporting

confidence: 91%

Section: Expression Of Npy Protein In Skin Pathologymentioning

confidence: 99%

Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology

et al. 2022

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“…The multifaceted role of the NPY system in tumours and its differential function are driven by the variability in the receptor signalling pathways and peptide expression (Tilan and Kitlinska 2016 ). The presence of NPY and its receptors was described in several neoplasms, such as PCa, breast cancer, melanoma, hepatocellular carcinoma (HCC), cholangiocarcinoma, neuroblastoma, Ewing sarcoma and pituitary adenoma (Reubi et al 2001 ; Kitlinska et al 2005 ; Levy et al 2006 ; DeMorrow et al 2011 ; Hong et al 2015 ; Lv et al 2016 ; Pérez Tato et al 2017 ). However, tissue expression of NPY receptor network has not been investigated in detail.…”

Section: Discussionmentioning

confidence: 99%

Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread

Sigorski

Wesołowski

Gruszecka

et al. 2022

J Cancer Res Clin Oncol

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Purpose Neuropeptide Y (NPY) is a pleiotropic peptide, which is involved in many biological mechanisms important in regulation of cell growth and survival. The aim of this study was a comprehensive analysis of the NPY system in prostate pathology. Methods The study was based on immunohistochemical analysis of NPY and its receptors, Y1R, Y2R and Y5R, in tissue samples from benign prostate (BP), primary prostate cancer (PCa) and PCa bone metastases. Tissue microarray (TMA) technique was employed, with analysis of multiple cores from each specimen. Intensity of the immunoreactivity and expression index (EI), as well as distribution of the immunostaining in neoplastic cells and stromal elements were evaluated. Perineural invasion (PNI) and extraprostatic extension (EPE) were areas of special interests. Moreover, a transwell migration assay on the LNCaP PCa cell line was used to assess the chemotactic properties of NPY. Results Morphological analysis revealed homogeneous membrane and cytoplasmic pattern of NPY staining in cancer cells and its membrane localization with apical accentuation in BP glands. All elements of the NPY system were upregulated in pre-invasive prostate intraepithelial neoplasia, PCa and metastases. EI and staining intensity of NPY receptors were significantly higher in PCa then in BP with correlation between Y2R and Y5R. The strength of expression of the NPY system was further increased in the PNI and EPE areas. In bone metastases, Y1R and Y5R presented high expression scores. Conclusion The results of our study suggest that the NPY system is involved in PCa, starting from early stages of its development to disseminated states of the disease, and participates in the invasion of PCa into the auto and paracrine matter.

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“…3d ) and expression of NPY in melanoma has been associated with nodular melanomas with vertical growth, metastasis and decreased lymphocyte infiltration ( Gilaberte et al , 2012 ). Note however, that the same group later linked NPY expression to good prognosis outcome ( Pérez Tato et al , 2017 ), indicating a complex role of NPY in melanoma. AXL was also found to make interactions using the molecular ligand adrenaline to β2 and α1A adrenoreceptors ( Fig.…”

Section: Resultsmentioning

confidence: 99%

scConnect: a method for exploratory analysis of cell–cell communication based on single-cell RNA-sequencing data

2021

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Motivation Cell to cell communication is critical for all multicellular organisms, and single cell sequencing facilitates the construction of full connectivity graphs between cell types in tissues. Such complex data structures demand novel analysis methods and tools for exploratory analysis. Results We propose a method to predict the putative ligand-receptor interactions between cell types from single cell RNA-sequencing data. This is achieved by inferring and incorporating interactions in a multidirectional graph, thereby enabling contextual exploratory analysis. We demonstrate that our approach can detect common and specific interactions between cell types in mouse brain and human tumors, and that these interactions fit with expected outcomes. These interactions also include predictions made with molecular ligands integrating information from several types of genes necessary for ligand production and transport. Our implementation is general and can be appended to any transcriptome analysis pipeline to provide unbiased hypothesis generation regarding ligand to receptor interactions between cell populations or for network analysis in silico. Availability scConnect is open source and available as a Python package athttps://github.com/JonETJakobsson/scConnect. scConnect is directly compatible with Scanpy scRNA-sequencing pipelines. Supplementary information Supplementary data are available at Bioinformatics online.

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Neuropeptide Y expression in primary cutaneous melanoma

Abstract: High expression of NPY was associated with better prognostic histological parameters, low peritumoral mast cells density, presence of adhesion proteins and better outcome.

Cited by 6 publications

References 27 publications

Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology

Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology

Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread

scConnect: a method for exploratory analysis of cell–cell communication based on single-cell RNA-sequencing data

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