Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)

Bojkowska, Karolina; Hamczyk, Magdalena M.; Tsai, Houng-Wei; Riggan, Anna E.; Rissman, Emilie F.

doi:10.1016/j.yhbeh.2007.10.013

Cited by 8 publications

(7 citation statements)

References 54 publications

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“…Crucially, these energetically aware GnRH‐II cells were associated with NPY‐ir fibres and, therefore, appear to work with NPY cells to coordinate the reproductive system response to energetic status (Bojkowska et al . ). Although, to our knowledge, experimental studies of the response of GnRH‐II to negative energetic status in birds are lacking, the available evidence in birds is consistent with a role similar to that in mammals (Maney, Richardson & Wingfield ; Stevenson & MacDougall‐Shackleton ; Stevenson et al .…”

Section: Discussionmentioning

confidence: 97%

Food availability, energetic constraints and reproductive development in a wild seasonally breeding songbird

et al. 2015

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Summary In many organisms, food availability is a proximate cue that synchronizes seasonal development of the reproductive system with optimal environmental conditions. Growth of the gonads and secondary sexual characteristics is orchestrated by the hypothalamic–pituitary–gonadal (HPG) axis. However, our understanding of the physiological mechanisms by which food availability modulates activity of the HPG axis is limited.It is thought that many factors, including energetic status, modulate seasonal reproductive activation. We tested the hypothesis that food availability modulates the activity of the HPG axis in a songbird. Specifically, we food‐restricted captive adult male Abert's Towhees Melozone aberti for 2 or 4 weeks during photoinduced reproductive development. A third group (control) received ad libitum food throughout. We measured multiple aspects of the reproductive system including endocrine activity of all three levels of the HPG axis [i.e. hypothalamic gonadotropin‐releasing hormone‐I (GnRH‐I), plasma luteinizing hormone (LH) and testosterone (T)], and gonad morphology. Furthermore, because gonadotropin‐inhibitory hormone (GnIH) and neuropeptide Y (NPY; a potent orexigenic peptide) potentially integrate information on food availability into seasonal reproductive development, we also measured the brain levels of these peptides.At the hypothalamic level, we detected no effect of food restriction on immunoreactive (ir) GnRH‐I, but the duration of food restriction was inversely related to the size of ir‐GnIH perikarya. Furthermore, the number of ir‐NPY cells was higher in food‐restricted than control birds. Food restriction did not influence photoinduced testicular growth, but decreased plasma LH and T, and width of the cloacal protuberance, an androgen‐sensitive secondary sexual characteristic. Returning birds to ad libitum food availability had no effect on plasma LH or T, but caused the cloacal protuberance to rapidly increase in size to that of ad libitum‐fed birds.Our results support the tenet that food availability modulates photoinduced reproductive activation. However, they also suggest that this modulation is complex and depends upon the level of the HPG axis considered. At the hypothalamic level, our results are consistent with a role for the GnIH and NPY systems in integrating information on energetic status. There also appears to be a role for endocrine function at the anterior pituitary gland and testicular levels in modulating reproductive development in the light of energetic status and independently of testicular growth.

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Section: Discussionmentioning

confidence: 97%

Food availability, energetic constraints and reproductive development in a wild seasonally breeding songbird

et al. 2015

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“…Recent study shows that increase in hypothalamic NPY gene expression by caloric restriction might result from the coordinate action of several factors including the decrease in serum leptin and insulin concentration [14]. Few other reports showed that increase in NPY level may stimulate feeding behaviour and inhibit GnRH release during some periods of feeding cycle [15], [3].…”

Section: Introductionmentioning

confidence: 99%

Intermittent Fasting Dietary Restriction Regimen Negatively Influences Reproduction in Young Rats: A Study of Hypothalamo-Hypophysial-Gonadal Axis

Kumar

Kaur

2013

PLoS ONE

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Nutritional infertility is very common in societies where women fail to eat enough to match their energy expenditure and such females often present as clinical cases of anorexia nervosa. The cellular and molecular mechanisms that link energy balance and central regulation of reproduction are still not well understood. Peripheral hormones such as estradiol, testosterone and leptin, as well as neuropeptides like kisspeptin and neuropeptides Y (NPY) play a potential role in regulation of reproduction and energy balance with their primary target converging on the hypothalamic median eminence-arcuate region. The present study was aimed to explore the effects of negative energy state resulting from intermittent fasting dietary restriction (IF-DR) regimen on complete hypothalamo-hypophysial-gonadal axis in Wistar strain young female and male rats. Significant changes in body weight, blood glucose, estrous cyclicity and serum estradiol, testosterone and LH level indicated the negative role of IF-DR regimen on reproduction in these young animals. Further, it was elucidated whether serum level of metabolic hormone, leptin plays a mechanistic role in suppressing hypothalamo-hypophysial-gonadal (HPG) axis via energy regulators, kisspeptin and NPY in rats on IF-DR regimen. We also studied the effect of IF-DR regimen on structural remodeling of GnRH axon terminals in median eminence region of hypothalamus along with the glial cell marker, GFAP and neuronal plasticity marker, PSA-NCAM using immunostaining, Western blotting and RT-PCR. Together these data suggest that IF-DR regimen negatively influences reproduction in young animals due to its adverse effects on complete hypothalamus-hypophysial-gonadal axis and may explain underlying mechanism(s) to understand the clinical basis of nutritional infertility.

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“…19,20 NPY content in the hypothalamus responds to food deprivation and refeeding, 21,22 and NPY stimulates food intake in many species including rat, mouse, musk shrew, and ring dove. [23][24][25][26][27][28] Five distinct NPY receptors have been isolated and designated Y1, Y2, Y4, Y5 and Y6, 29 with the Y1, Y2 and Y5 NPY receptors involved in the regulation of food intake. 30 Moreover, 5-HT and NPY appear to cooperate in the regulation of food intake.…”

Section: Introductionmentioning

confidence: 99%

Duck cerebellum participates in regulation of food intake via the neurotransmitters serotonin and neuropeptide Y

Liu

Tong

et al. 2008

Nutritional Neuroscience

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Two important neurotransmitters, serotonin (5-hydroxytryptamine, 5-HT) and neuropeptide Y (NPY), have been confirmed to be involved in food intake regulation. To clarify whether the cerebellum participates in modulation of food intake through these two neurotransmitters, we investigated the distribution and expression levels of 5-HT and NPY in cerebellum of the duck. Our results showed that 5-HT and NPY were distributed only at the Purkinje cell layer of the duck cerebellum. Moreover, the expression level of 5-HT in fasted (4 h) and tryptophan (100-200 mg/kg)-treated ducks was significantly higher than that in control animals (P<0.01), whereas the expression of NPY was significantly decreased (P<0.01). Therefore, our results indicated that inhibitory regulation of food intake respectively increased and decreased cerebellar 5-HT and NPY in the duck.

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Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)

Cited by 8 publications

References 54 publications

Food availability, energetic constraints and reproductive development in a wild seasonally breeding songbird

Food availability, energetic constraints and reproductive development in a wild seasonally breeding songbird

Intermittent Fasting Dietary Restriction Regimen Negatively Influences Reproduction in Young Rats: A Study of Hypothalamo-Hypophysial-Gonadal Axis

Duck cerebellum participates in regulation of food intake via the neurotransmitters serotonin and neuropeptide Y

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