Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease

Abstract

Our results suggested a relationship between CSF NpY levels and nutritional indices in CKD patients. High serum NpY concentrations may be a risk factor associated with CVD.

Astragalus polysaccharides decrease muscle wasting through Akt/mTOR, ubiquitin proteasome and autophagy signalling in 5/6 nephrectomised rats

“…Maintaining the protein content in muscles may improve these patients' clinical outcomes. Early research attributed wasting to malnutrition and insufficient protein intake, and researchers focused on appetite-regulating pathways, such as neuropeptide signalling (Lu et al, 2015;Morley and Farr, 2008). However, epidemiological studies have concluded that the excessive morbidity and mortality of CKD patients is rarely attributable to malnutrition (Fouque et al, 2008;Stenvinkel et al, 2004).…”

Advances and highlights in mechanisms of allergic disease in 2015

“…Perceived stress has been presented as a persistent precipitating effect in increasing T H 2 responses in asthmatic patients, and this effect might be mediated by peripheral blood levels of neuropeptide Y. 124 Neuropeptide Y levels consistent with a dampened response associated with chronic psychological stress were lower among young patients with acutely exacerbated and nonexacerbated asthma compared with healthy control subjects. Among asthmatic patients, neuropeptide Y appeared to play a role in the association between perceived stress and the persistently increased IL-4 levels of the type 2 immune response.…”

Pro-Inflammatory Profile of Adipokines in Obesity Contributes to Pathogenesis, Nutritional Disorders, and Cardiovascular Risk in Chronic Kidney Disease

“…The concentration of serum NPY increases, but cerebrospinal fluid (CSF) NPY decreases with the progression of CKD. A low concentration of CSF NPY was associated with cachexia, reduced energy intake, and muscle-wasting among CKD patients [ 70 ]. It has been observed that higher serum NPY levels prognosticate cardiovascular mortality among dialysis patients [ 71 , 72 ].…”