Neurophysiological Changes in Patients with Chronic Obstructive Pulmonary Diseases

Demir, Recep; Özel, Lütfi; Özdemir, Gökhan; Kocatürk, İdris; Ulvi, Hızır

doi:10.15197/sabad.1.11.61

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…In the present study peripheral neuropathy has occurred at an incidence of 44.4% in patients with COPD.The prevalence of PN among COPD patients showed wide variety in previous studies (5% to 100% ) [4,5,16,18,[20][21][22][23][24][25][26]. In line with the previous studies, the distribution and types of neuropathic parameters mostly indicated involvement of lower extremities and manifestation as sensorial NP [4,20,23,24].…”

Section: Discussionsupporting

confidence: 86%

The incidence of polyneuropthy and its relation with disease parameters in chronic obstructive pulmonary disease

Ogan

Sayın

Baha

et al. 2019

The European Research Journal

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Objective: Chronic Obstructive Pulmonary Disease (COPD) is accompanied by several concomitant conditions due to its systemic effects. Hypoxia and oxidative stress associated with COPD are also believed to contribute to the disease course through the effects of several inflammatory mediators. Major causative agents causing of peripheral neuropathy are age, hypoxia, duration and severity of COPD, hypercapnia and smoking. The present study aimed to investigate the incidence of polyneuropathy and its relation with disease parameters in COPD patients. Methods: Of a total number of 45 patients who had been followed up between January 1, 2015 and December 31, 2016 with a diagnosis of COPD at Ufuk University School of Medicine were enrolled retrospectively. All patients underwent electroneuromyography, arterial blood gas measurements and pulmonary function tests. Patients were divided as those with or without neuropathy, and factors contributing to the development of neuropathy were investigated based on clinical and laboratory findings. Results: Eleven (24.4%) patients were women and 34 (74.6%) were men, and the mean age was 73.2 years. Mean PaO2 was 58.2 mmHg, pCO2 was 41.2 mmHg, and FEV1 was 45.3%. Neuropathy was diagnosed in twenty (44.4%) patients. Significant differences were found in pO2, pCO2, SO2, mMRC, smoking status and number of exacerbations per year (p < 0.05). Conclusions: Patients who experience frequent exacerbations and those with hypoxemia or hypercapnia as demonstrated should be taken into more careful clinical assessments with respect to polyneuropathy.

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Section: Discussionsupporting

confidence: 86%

The incidence of polyneuropthy and its relation with disease parameters in chronic obstructive pulmonary disease

Ogan

Sayın

Baha

et al. 2019

The European Research Journal

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“…Demir et al [22], noticed peripheral neuropathy in (93.5%) of the studied patients (31 subjects) on EMG the sensory nerve conduction abnormalities were the most common, the sural nerve affected in (29 subjects), the ulnar nerve (26), median nerve (28), and motor nerve conduction abnormalities; peroneal (7), median nerve (2), tibial and ulnar nerve (1). And they concluded that the frequency of neuropathy, particularly sensorial, was more than expected, with a significant positive correlation between the degree of hypoxemia and the severity of neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiological biomarkers of peripheral nervous system affection in patients with stable chronic obstructive pulmonary disease (COPD)

Ali

Al-Adl

2021

Egypt J Neurol Psychiatry Neurosurg

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Background Chronic obstructive pulmonary disease (COPD) is accompanied by substantial systemic dysregulations that comprise systemic inflammation and neurohormonal activation in addition to many neurological involvements, such as cerebrovascular diseases, polyneuropathies, motor neuron diseases, and cognitive impairment has been described in COPD patients. The aim of the current work was to detect the subclinical affection of the peripheral nervous system in patients with stable COPD. Results Forty COPD patients and 30 subjects as healthy control were enrolled. All included subjects were submitted to complete medical history, clinical evaluations, investigations in the form of; arterial blood gases, spirometry, in addition to nerve conduction study. The patients with COPD were classified according to GOLD criteria for severity in grade I in 7.5% grade II in 62.5%, grade III in 20%, and grade IV in 10%. The results show a statistically significant increase in distal latency and a statistically significant decrease of amplitude and conduction velocity in patients with COPD when compared to the examined nerves of control group. The demyelinating nerve affection was the most common. Conclusion In COPD patients the peripheral nervous system could be affected subclinically once the severity of COPD increased and the patient should be neurophysiologically observed for early recognition of peripheral nervous system affection.

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A cross-sectional study on nerve conduction velocity in stable chronic obstructive pulmonary disease

Chadha

Shivalkar

Ramraje

2021

IJPP

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Objectives: This study was undertaken with the aim to find out possible presence of subclinical peripheral neuropathy in patients of chronic obstructive pulmonary disease (COPD) and its association with advancing severity of disease. Changes in nerve conduction parameter values in these patients have been presented. Materials and Methods: Median, ulnar, peroneal motor, and sural sensory nerve conduction latency, amplitude, and velocity were recorded in 100 known cases of COPD in the age group of 25–65 years as per the standard protocol. Results: On analysis, statistically significant lowering of sural nerve conduction velocity (P = 0.002) and amplitude (P = 0.003) was found with decreasing FEV1% in the three stages of COPD. Decrease in ulnar sensory conduction amplitude and velocity was also noted but it was not significant. Fall in sural nerve conduction velocity was found to be strongly and positively correlated (P = 0.029, r = 0.444) with decrease in FEV1%. Conclusion: These findings suggest that with increasing severity of disease, airflow limitation enhances polyneuropathy in COPD patients. It is predominantly axonal and mainly involving sensory nerve.

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Neurophysiological Changes in Patients with Chronic Obstructive Pulmonary Diseases

Abstract: Peripheral neuropathy commonly occurs in patients with chronic obstructive lung disease (COPD).

Cited by 3 publications

References 7 publications

The incidence of polyneuropthy and its relation with disease parameters in chronic obstructive pulmonary disease

The incidence of polyneuropthy and its relation with disease parameters in chronic obstructive pulmonary disease

Neurophysiological biomarkers of peripheral nervous system affection in patients with stable chronic obstructive pulmonary disease (COPD)

A cross-sectional study on nerve conduction velocity in stable chronic obstructive pulmonary disease

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