Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region

Lugli, Licia; Pugliese, Marisa; Plessi, Carlotta; Berardi, Alberto; Guidotti, Isotta; Ancora, Gina; Grandi, Sara; Gargano, Giancarlo; Braibanti, Silvia; Sandri, Fabrizio; Soffritti, Silvia; Ballardini, Elisa; Arena, Vittoria; Stella, Marcello; Perrone, Serafina; Moretti, Silvia; Rizzo, Vittoria; Ferrari, Fabrizio; Picciolini, Odoardo; Bellù, Roberto; Turoli, Daniela; Corvaglia, Luigi; Garani, Giampaolo; Paoletti, Vittoria; Biasucci, Giacomo; Biasini, Augusto; Benenati, Belinda; Stagi, Paolo; Magnani, Cristina; Dallaglio, Sara; Muttini, Elisa DellaCasa; Roversi, Maria Federica; Bedetti, Luca; Lucaccioni, Laura; Bertoncelli, Natascia; Boncompagni, Alessandra

doi:10.1186/s13052-020-0787-7

Cited by 16 publications

(17 citation statements)

References 24 publications

(38 reference statements)

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“…The BSDI III provides standardized composite scores for each of the assessed domains (cognitive, fine, and gross motor; receptive and expressive language; adaptive), with a mean of 100 and an SD of 15 ( 17 ). For both the GMDS-R and the BSID-III, the cutoff abnormality was two SDs below the normative mean ( 13 , 18 ). The BSDI III or GMDS-R results were compared among three groups of different GAs.…”

Section: Methodsmentioning

confidence: 87%

“…Therefore, it is of paramount importance that recent, representative outcome data be available. Up-to-date data are scant regarding the neurodevelopment of very low birth weight (VLBW) infants, and national networks on preterm neurological outcomes are still lacking in Italy, but the Neuroprem study has recently produced preliminary data on the neurodevelopmental outcomes of a VLBW cohort in an Italian region during a 1-year period ( 13 ). Neuroprem is now expanding to a larger Italian area including nine neonatal intensive care units NICUs and to a longer study period (Neuroprem 2).…”

Section: Introductionmentioning

confidence: 99%

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Neuroprem 2: An Italian Study of Neurodevelopmental Outcomes of Very Low Birth Weight Infants

Lugli¹,

Bedetti

Guidotti³

et al. 2021

Front. Pediatr.

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Background: Despite the increased survival of preterm newborns worldwide, the risk of neurodevelopmental disabilities remains high. Analyzing the outcomes of the preterm population can identify risk factors and enable specific early interventions.Aims: Neuroprem is a prospective cohort study of very low birth weight (VLBW) infants that aims to evaluate the neurodevelopmental outcomes and risk factors for severe functional disability at 2 years of corrected age.Methods: Nine Italian neonatal intensive care units participated in the network. The Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and a neuro-functional evaluation (according to the International Classification of Disability and Health and Neuro-Functional Assessment, or NFA ICF-CY) were administered to VLBW infants at 24 months of corrected age. The primary outcome measure was severe functional disability, defined as cerebral palsy, bilateral blindness, deafness, an NFA ICF-CY of >2, a BSDI III cognitive composite score of <2 SD, or a GMDS-R global quotient score of <2 SD. Perinatal risk factors for severe functional disability were assessed through multivariate logistic regression analysis.Results: Among 502 VLBW survivors who completed the 24-month follow-up, 48 (9.6%) presented severe functional disability, of whom 27 had cerebral palsy (5.4%). Rates of severe functional disability and cerebral palsy were higher in neonates with a lower gestational age (p < 0.001). Overall, 147 infants (29.3%) were referred to neuromotor intervention. In the multivariate regression model, gestational age at birth OR 0.79; 95% CI 0.67–0.90; p = 0.001) and periventricular-intraventricular hemorrhage (OR 2.51; 95% CI 1.19–5.26; p = 0.015) were significantly associated with severe functional disability.Conclusion: Neuroprem 2 provides updated information on the neurodevelopmental outcomes of VLBW infants in a large Italian cohort. The overall rate of neurodevelopmental disabilities was quite lower than reported in the previous literature. These data indicate the need for structured follow-up programs from a national neonatal network perspective.

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Section: Methodsmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Neuroprem 2: An Italian Study of Neurodevelopmental Outcomes of Very Low Birth Weight Infants

Lugli¹,

Bedetti

Guidotti³

et al. 2021

Front. Pediatr.

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“…Серед дітей з надзвичайно малою масою тіла переважна більшість вже у ранньому дитячому віці страждають на стійкі нейро-моторні та сенсорні дефіцити. Окрім того, вони достовірно частіше потребують неврологічної реабілітації та мають нижчі показники нервово-психічного розвитку [8].…”

Section: актуальні питання організації неонатології та перинатальної ...unclassified

Brain Injury in Preterm Infants - Patients of the Department of Intensive Therapy of Newborn

Yablon¹,

Bondarenko²,

Vlasenko³

et al. 2022

Neonatol. hìr. perinat. med.

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Introduction. Advances in reproductive and perinatal technologies have led not only to an increase in the number of premature babies and an increase in survival rates, but also to an increase in the incidence of complications. Nervous system diseases play a leading role in the structure of pathologies of premature infants. Early onset of extrauterine life contributes to the disruption of physiological processes of brain maturation, increasing the risk of neurological complications.Objective. To establish the frequency and structure of brain damage in premature infants-patients of the intensive care unit. Materials and methods. The mortality and morbidity rates of premature infants-patients of the intensive care unit who were born in 2019-2020 and the first 3 quarters of 2021 were estimated. The frequency of lesions of the nervous system in premature infants, namely the presence of intraventricular hemorrhages of varying severity, hypoxic-ischemic encephalopathy, periventricular leukomalacia, hydrocephalus. Statistical processing of the obtained results was performed using the software system Microsoft Excel 2010 (14.0.6024.1000) SP 1 MSO (14.0.6023.1000).Results. In 2021, the number of premature babies weighing <1,500 g increased compared to 2019. The decrease in mortality rates of premature infants-patients of the intensive care unit was revealed. The most common pathologies of premature infants are respiratory distress syndrome and lesions of the nervous system. Analysis of the obtained data showed that the structure of neurological pathology in premature infants is dominated by hypoxic-ischemic encephalopathy and intraventricular hemorrhage.Conclusions. Against the background of declining mortality rates, the number and severity of HSV in premature infants are increasing.

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“…Child with low birth weight (LBW) have a higher risk of infant mortality, learning difficulties in childhood due to stunted growth and impaired neurodevelopment, and are more likely to develop heart disease and diabetes in adulthood [ 1 , 2 , 3 , 4 ]. According to the World Health Organisation (WHO) child born under the weight of 2500 gm is considered LBW.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Low Birthweight in Low-and-Middle Income Countries in South Asia

Ngo

Bhowmik

Biswas

2022

IJERPH

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Child with Low Birth Weight (LBW) has a higher risk of infant mortality, learning difficulties in childhood due to stunted growth and impaired neurodevelopment, is more likely to develop heart diseases and diabetes in adulthood. This study aimed to evaluate the latest demographic and health surveys (DHSs) across multiple countries in South Asia to determine the factors associated with LBW among these countries. Latest available DHS data across Afghanistan (2015, n = 29,461), Bangladesh (2018, n = 20,127), Nepal (2016, n = 12,862), and Pakistan (2018, n = 15,068) were analysed. Complex survey adjusted generalized linear models were fitted to investigate the association of birth weight with sociodemographic and decision-making factors. Pakistan had the highest proportion of LBW at 18% followed by Afghanistan and Bangladesh at around 14% and Nepal had the lowest (13%). Children born in Pakistan were more likely to have LBW children than Afghanistan (AOR = 2.17, 95% CI = 1.49–3.14). Mothers living in rural areas (AOR = 0.77, 95% CI = 0.61–0.97), with highly educated partners and belonging to richer families were less susceptible to having child with LBW. To reduce 30% LBW in-line with the World Health Organisation’s 2025 goal, policymakers in SA should focus on women in urban areas with low-educated partners belonging to poor households to ease LBW burden.

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Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region

Cited by 16 publications

References 24 publications

Neuroprem 2: An Italian Study of Neurodevelopmental Outcomes of Very Low Birth Weight Infants

Neuroprem 2: An Italian Study of Neurodevelopmental Outcomes of Very Low Birth Weight Infants

Brain Injury in Preterm Infants - Patients of the Department of Intensive Therapy of Newborn

Factors Associated with Low Birthweight in Low-and-Middle Income Countries in South Asia

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