Neuroprotection care bundle implementation is associated with improved long-term neurodevelopmental outcomes in extremely premature infants

Benlamri, Amina; Murthy, Prashanth; Zein, Hussein; Thomas, Sumesh; Scott, James N.; Mehrem, Ayman Abou; Esser, Michael J.; Lodha, Abhay; Noort, Jennessa; Tang, Selphee; Metcalfe, Cathy; Kowal, Derek; Irvine, Leigh; Scotland, Jillian; Leijser, Lara M.; Mohammad, Khorshid

doi:10.1038/s41372-022-01443-0

Cited by 7 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, over two-thirds of the preterm infants under scrutiny were male. This result is matched with Benlamri, et al, (2022) in their study about "Neuroprotection care bundle implementation is associated with improved long-term neurodevelopmental outcomes in extremely preterm infants" as they found that IVH is a critical concern in preterm infants, particularly affecting males. Studies indicate that more than two-thirds of preterm infants experiencing IVH are male.…”

Section: Table (6)supporting

confidence: 68%

Evaluating the Effect of a Neuro-protective Care Bundle for Neonatal Nurses on Rate of Seriousness of Intraventricular Hemorrhage among Preterm Infants

Abd Elsamea Elguoshy Hassanen,

EL-Sayed Hassan,

Mustafa Abu Samra

et al. 2023

Egyptian Journal of Health Care

View full text Add to dashboard Cite

Background. Intraventricular hemorrhage (IVH) poses a significant risk for preterm infants in Neonatal Intensive Care Units (NICU). Globally, nurses in the NICUs may adopt various strategies and protocols to reduce the incidence of IVH in preterm infants and mitigate potential neurodevelopmental complications. Aim. To evaluate the effect of implementing a neuro-protective care bundle for neonatal nurses on rate of seriousness of IVH among preterm infants. Design. A quasi-experimental research design was utilized. Setting. This study was carried out at

show abstract

Section: Table (6)supporting

confidence: 68%

Evaluating the Effect of a Neuro-protective Care Bundle for Neonatal Nurses on Rate of Seriousness of Intraventricular Hemorrhage among Preterm Infants

Abd Elsamea Elguoshy Hassanen,

EL-Sayed Hassan,

Mustafa Abu Samra

et al. 2023

Egyptian Journal of Health Care

View full text Add to dashboard Cite

show abstract

“…197 Recent studies showed the implementation of such neuroprotection bundles targeting some or all those key elements using Quality Improvement (QI) methodology decreased the incidence of acute brain injury and improved long-term neurodevelopment outcomes in extremely premature infants born at and outside tertiary centers. [198][199][200][201][202] Neuroplasticity interventions, unlike those for acute brain injury, target potential brain injury and growth well beyond the first few days of birth and after discharge. 203 The key elements of such bundles include the non-pharmacological interventions discussed in detail above, including empowering families through familycentered care model; 181 optimizing nutrition; 204 developmental care; 205 skin-to-skin care and massage therapy; 206,207 positive stimulating sounds such as music therapy and reading programs, 208 parental voice, 209,210 minimizing disturbing noises, 211 enhancing physiologic sleep-wake cycles 212 and encouraging positive social interaction.…”

Section: Key Driversmentioning

confidence: 99%

Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series)

Molloy,

El-Dib,

Soul

et al. 2023

Pediatr Res

Self Cite

View full text Add to dashboard Cite

The survival of preterm infants has steadily improved thanks to advances in perinatal and neonatal intensive clinical care. The focus is now on finding ways to improve morbidities, especially neurological outcomes. Although antenatal steroids and magnesium for preterm infants have become routine therapies, studies have mainly demonstrated short-term benefits for antenatal steroid therapy but limited evidence for impact on long-term neurodevelopmental outcomes. Further advances in neuroprotective and neurorestorative therapies, improved neuromonitoring modalities to optimize recruitment in trials, and improved biomarkers to assess the response to treatment are essential. Among the most promising agents, multipotential stem cells, immunomodulation, and anti-inflammatory therapies can improve neural outcomes in preclinical studies and are the subject of considerable ongoing research. In the meantime, bundles of care protecting and nurturing the brain in the neonatal intensive care unit and beyond should be widely implemented in an effort to limit injury and promote neuroplasticity. Impact With improved survival of preterm infants due to improved antenatal and neonatal care, our focus must now be to improve long-term neurological and neurodevelopmental outcomes. This review details the multifactorial pathogenesis of preterm brain injury and neuroprotective strategies in use at present, including antenatal care, seizure management and non-pharmacological NICU care. We discuss treatment strategies that are being evaluated as potential interventions to improve the neurodevelopmental outcomes of infants born prematurely.

show abstract

Preterm Neurodevelopmental Trajectories from 18 Months to 4.5 Years

Christensen¹,

Chau²,

Synnes³

et al. 2023

The Journal of Pediatrics

View full text Add to dashboard Cite

Neuroprotection care bundle implementation is associated with improved long-term neurodevelopmental outcomes in extremely premature infants

Cited by 7 publications

References 33 publications

Evaluating the Effect of a Neuro-protective Care Bundle for Neonatal Nurses on Rate of Seriousness of Intraventricular Hemorrhage among Preterm Infants

Evaluating the Effect of a Neuro-protective Care Bundle for Neonatal Nurses on Rate of Seriousness of Intraventricular Hemorrhage among Preterm Infants

Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series)

Preterm Neurodevelopmental Trajectories from 18 Months to 4.5 Years

Contact Info

Product

Resources

About