Neuroprotection of Bone Marrow-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicle-Enclosed miR-410 Correlates with HDAC4 Knockdown in Hypoxic-Ischemic Brain Damage

Shen, Mingqi; Zheng, Rongxiu; Kan, Xuan

doi:10.1007/s11064-022-03670-5

Cited by 8 publications

(3 citation statements)

References 61 publications

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“…MiR-29b-3p can promote angiogenesis and decrease neuronal death by significantly regulating PTEN and activating the Akt signaling pathway [ 88 ]. MiR-410 attenuates apoptosis by inhibiting HDAC4-dependent Wnt pathway activation [ 89 ]. MiR-455–5p promotes autophagy and inhibits neuronal apoptosis through the negative regulation of Nogo-A [ 90 ].…”

Section: The Therapeutic Mechanism Of Mscs In Neurological Disordersmentioning

confidence: 99%

Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease

Chen,

Huang,

et al. 2024

Regenerative Therapy

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Section: The Therapeutic Mechanism Of Mscs In Neurological Disordersmentioning

confidence: 99%

Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease

Chen,

Huang,

et al. 2024

Regenerative Therapy

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“…BMSC-EVs containing the long non-coding RNA ZNFX1 antisense RNA 1 (ZFAS1) exhibited a potentially therapeutic effect on ischemic brain injury [ 95 ]. Shen et al [ 96 ] demonstrated that BMSC-EVs transported miR-410 to target HDAC4, thereby preventing brain damage in hypoxic-ischemic mice. The protective effect may be attributed to the downregulation of phosphatase.…”

Section: Bone-organ Axesmentioning

confidence: 99%

Bone-organ axes: bidirectional crosstalk

Deng,

Wang,

Wang

et al. 2024

Military Med Res

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In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteokines). This reciprocal influence extends to these organs modulating bone homeostasis and development, although this aspect has yet to be systematically reviewed. This review aims to elucidate this bidirectional crosstalk, with a particular focus on the role of osteokines. Additionally, it presents a unique compilation of evidence highlighting the critical function of extracellular vesicles (EVs) within bone-organ axes for the first time. Moreover, it explores the implications of this crosstalk for designing and implementing bone-on-chips and assembloids, underscoring the importance of comprehending these interactions for advancing physiologically relevant in vitro models. Consequently, this review establishes a robust theoretical foundation for preventing, diagnosing, and treating diseases related to the bone-organ axis from the perspective of cytokines, EVs, hormones, and metabolites.

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“…BMSC-exos carrying the long non-coding RNA ZFAS1 suppress oxidative stress and inflammation associated with ischemic stroke (Yang and Chen 2022 ). MiR-410 delivered by BMSC-EVs targets HDAC4 and prevents brain damage in hypoxic–ischemic mice (Shen et al 2022 ). The downregulation of phosphatase and tensin homologs, which led to the activation of the PI3K/protein kinase B/rapamycin mechanistic target/glycogen synthase kinase-3 beta signaling pathway, may be partially responsible for the improvement in neural plasticity and recovery after stroke after intravenous administration of miR-17-92 cluster-enriched BMSC-exos.…”

Section: Evs In Brain–bone Marrow Crosstalkmentioning

confidence: 99%

Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles

et al. 2023

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A number of substances released by the brain under physiological and pathological conditions exert effects on other organs. In turn, substances produced primarily by organs such as bone marrow, adipose tissue, or the heart may have an impact on the metabolism and function and metabolism of the healthy and diseased brain. Despite a mounting amount of evidence supports such bidirectional communication between the brain and other organs, research on the function of molecular mediators carried by extracellular vesicles (EVs) is in the early stages. In addition to being able to target or reach practically any organ, EVs have the ability to cross the blood–brain barrier to transport a range of substances (lipids, peptides, proteins, and nucleic acids) to recipient cells, exerting biological effects. Here, we review the function of EVs in bidirectional communication between the brain and other organs. In a small number of cases, the role has been explicitly proven; yet, in most cases, it relies on indirect evidence from EVs in cell culture or animal models. There is a dearth of research currently available on the function of EVs-carrying mediators in the bidirectional communication between the brain and bone marrow, adipose tissue, liver, heart, lungs, and gut. Therefore, more studies are needed to determine how EVs facilitate communication between the brain and other organs.

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Neuroprotection of Bone Marrow-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicle-Enclosed miR-410 Correlates with HDAC4 Knockdown in Hypoxic-Ischemic Brain Damage

Cited by 8 publications

References 61 publications

Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease

Therapeutic potential of mesenchymal stem cells for cerebral small vessel disease

Bone-organ axes: bidirectional crosstalk

Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles

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