2006
DOI: 10.1097/wco.0b013e3280102b10
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Neuroprotection targets after traumatic brain injury

Abstract: Clearly, finding treatments for traumatic brain injury is not going to be easy and is evidently going to require numerous trials. The good news is that we are closer to finding one or more methods for treating traumatic brain injury patients.

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Cited by 104 publications
(63 citation statements)
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“…It has been suggested that oxidative stress induces calcium influx in several neurodegenerative diseases causing activation of calpains and other enzymes (1,3). Our findings indicate that calpain-1 KO neurons show a defect in the calcium entry pathway mediated by oxidative stress (Fig.…”
Section: Discussionsupporting
confidence: 61%
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“…It has been suggested that oxidative stress induces calcium influx in several neurodegenerative diseases causing activation of calpains and other enzymes (1,3). Our findings indicate that calpain-1 KO neurons show a defect in the calcium entry pathway mediated by oxidative stress (Fig.…”
Section: Discussionsupporting
confidence: 61%
“…Increased oxidative stress followed by calcium influx, mitochondrial dysfunction, and the loss of cytoskeletal proteins are phenotypes commonly observed in Alzheimer, Huntington, and Parkinson diseases, as well as amyotrophic lateral sclerosis, stroke, ischemia, spinal cord injury, and TBI (1,3,4). An elevated intracellular calcium concentration will hyper-activate calcium-activated neutral proteases called calpains.…”
mentioning
confidence: 99%
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“…[14][15][16] However, no clinically proven neuroprotective therapy to reduce neuronal damage and improve learning and memory has been identified. [17][18][19] Endoplasmic reticulum (ER) function is critical for maintaining intracellular calcium homeostasis, lipid biosynthesis, protein folding, and transport. Protein folding within the ER is highly sensitive to Ca 2 + levels, redox states, and nutrient status.…”
Section: Introductionmentioning
confidence: 99%
“…Fagan et al 2010;Gupta and Chauhan 2011) as well as spinal cord and traumatic brain injury (e.g. Wang et al 2006;Hawryluk et al 2008). It is concluded that the cytoprotective capability of minocycline results from its anti-inflammatory, anti-apoptotic, and antioxidant properties (e.g.…”
Section: Introductionmentioning
confidence: 99%