Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration
Wachiryah Thong-asa,
Chatrung Wassana,
Kunyarat Sukkasem
et al.
Abstract:We investigated the effect of gallic acid against neurodegenerative pathophysiology relevant to PD in mice with rotenone-induced toxicity. Forty male ICR mice were randomly divided into four groups: sham-veh, PD-veh (received subcutaneous injection with 2.5 mg/kg/48 hours of rotenone); PD-Gal50; and PD-Gal100 (the latter two groups received subcutaneous injection with 2.5 mg/kg/48 hours of rotenone and oral gavage with gallic acid 50 and 100 mg/kg/48 hours, respectively). All treatments continued for 5 weeks w… Show more
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