Neuroprotective Effect of Resveratrol
Against Glutamate-Induced Excitotoxicity

Zhang, Li-Nan; Hao, Liang; Wang, Haiyan; Sun, Youxian; Yang, Xiaoyue; Chen, Bin; Xue, Jianyang; Z, Gao

doi:10.17219/acem/38144

Cited by 34 publications

(22 citation statements)

References 37 publications

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“…The present study found that resveratrol reduced the number of alcohol-induced microglial cells and neuron cells, and inhibited the increased levels of NF-κB, TNF-α, SOD and GSH in alcohol-induced rats. Zhang et al reported the neuroprotective effects of resveratrol against glutamate-induced excitotoxicity in neurodegenerative diseases (14), and Abengózar-Vela et al demonstrated that resveratrol reduced inflammatory and oxidative damage in human ocular surface epithelial cells (15). AMPK has protective and reparative effects on developing and mature neurons, which can enhance the uptake of neurons cultured in vitro and promote the differentiation of neurons (16).…”

Section: Discussionmentioning

confidence: 99%

AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol

Cai

et al. 2018

Mol Med Report

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Resveratrol has also been approved for use in enhancing plant disease resistance and reducing pesticide use. A number of studies have shown that the disease resistance of crops treated with resveratrol is markedly improved. The aim of the present study was to examine the protective effect of resveratrol against alcohol‑induced neurodegeneration occurred and its association with AMP‑activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/p38 in rats and humans. ELISA, caspase‑3 activity and western blot analyses were employed in the present study. Sprague‑Dawley rats and human neuroblastoma SH‑SY5Y cells were treated with alcohol to establish the alcohol‑induced model. Resveratrol protected against alcohol‑induced neuron damage in the hippocampus of the rats. Treatment with resveratrol also inhibited the alcohol‑induced inflammatory response, oxidative stress, caspase‑3 activities and B‑cell lymphoma (Bcl‑2)‑associated X protein/Bcl‑2 in the alcohol‑induced rat. Resveratrol also reduced the upregulated protein expression of AMPK and SIRT1, preventing the pro‑apoptotic alcohol‑induced protein expression of p38 in the rats exposed to alcohol. The downregulation of AMPK suppressed the expression of SIRT1 and activated the expression of p38 in the SH‑SY5Y cell model. Taken together, the data obtained suggested that resveratrol protected against alcohol‑induced neurodegeneration via the AMPK/SIRT1/p38 pathway in rats and humans.

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Section: Discussionmentioning

confidence: 99%

AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol

Cai

et al. 2018

Mol Med Report

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“…Many drugs are being investigated along with natural products such as resveratrol. This naturally occurring polyphenol, mainly found in grapes and red wine, has shown in vitro and in vivo neuroprotective effects for a variety of experimental models of neurodegenerative diseases (Zhang et al, 2015). This and other natural products such as TUDCA (Fernandez-Sanchez et al, 2011) or safranal deserve further investigation .…”

Section: A Look Into the Futurementioning

confidence: 99%

Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical consequences

Pastor

Rojas

Pastor‐Idoate

et al. 2016

Progress in Retinal and Eye Research

273

261

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“…Resveratrol is also able to enhance hippocampal plasticity and hippocampal neurogenesis [ 17 ]. Recently, a number of studies have focused on the neuroprotective effects of resveratrol, including its ability to diminish the toxicity induced by the amyloid beta peptide [ 18 , 19 ] and kainic acid [ 20 ], as well as prevent cerebral ischemic damage [ 16 , 21 ]. In addition, animal studies have demonstrated the efficacy of resveratrol to reverse learning and memory impairments in aged animals [ 16 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

A maternal high-fat diet during pregnancy and lactation, in addition to a postnatal high-fat diet, leads to metabolic syndrome with spatial learning and memory deficits: beneficial effects of resveratrol

Sheen

et al. 2017

Oncotarget

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We tested the hypothesis that high-fat diet consumption during pregnancy, lactation, and/or post weaning, altered the expression of molecular mediators involved in hippocampal synaptic efficacy and impaired spatial learning and memory in adulthood. The beneficial effect of resveratrol was assessed. Dams were fed a rat chow diet or a high-fat diet before mating, during pregnancy, and throughout lactation. Offspring were weaned onto either a rat chow or a high-fat diet. Four experimental groups were generated, namely CC, HC, CH, and HH (maternal chow diet or high-fat diet; postnatal chow diet or high-fat diet). A fifth group fed with HH plus resveratrol (HHR) was generated. Morris water maze test was used to evaluate spatial learning and memory. Blood pressure and IPGTT was measured to assess insulin resistance. Dorsal hippocampal expression of certain biochemical molecules, including sirtuin 1, ERK, PPARγ, adiponectin, and BDNF were measured. Rats in HH group showed impaired spatial memory, which was partly restored by the administration of resveratrol. Rats in HH group also showed impaired glucose tolerance and increased blood pressure, all of which was rescued by resveratrol administration. Additionally, SIRT1, phospho-ERK1/2, and phospho-PPARγ, adiponectin and BDNF were all dysregulated in rats placed in HH group; administration of resveratrol restored the expression and regulation of these molecules. Overall, our results suggest that maternal high-fat diet during pregnancy and/or lactation sensitizes the offspring to the adverse effects of a subsequent high-fat diet on hippocampal function; however, administration of resveratrol is demonstrated to be beneficial in rescuing these effects.

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Neuroprotective Effect of Resveratrol Against Glutamate-Induced Excitotoxicity

Cited by 34 publications

References 37 publications

AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol

AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol

Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical consequences

A maternal high-fat diet during pregnancy and lactation, in addition to a postnatal high-fat diet, leads to metabolic syndrome with spatial learning and memory deficits: beneficial effects of resveratrol

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