Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition

Amylin: Pharmacology, Physiology, and Clinical Potential

“…Chronic infusions of pramlintide in the senescenceaccelerated prone mouse (a model of sporadic AD) improved performance in the novel object recognition task (assay for memory and cognition). These behavioral effects were accompanied by increased markers of synaptic formation and decreased markers of inflammation and oxidative stress within the hippocampus (Adler et al, 2014). Likewise, both amylin and pramlintide administration in a transgenic model of AD improved learning and memory in the Y-maze and Morris swim tests.…”

“…Two recent reports suggest that peripheral treatment with either amylin or pramlintide can have therapeutic effects in Alzheimer's disease (AD) (Adler et al, 2014;Zhu et al, 2015). First, lower amylin levels were noted among subjects with AD and mild cognitive impairment compared with the cognitively intact subjects (Adler et al, 2014).…”

“…First, lower amylin levels were noted among subjects with AD and mild cognitive impairment compared with the cognitively intact subjects (Adler et al, 2014). This led the authors to test whether chronic infusions of the amylin analog pramlintide would be beneficial in rodent models of AD.…”

Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer’s Disease

“…Two studies have shown that the plasma concentration of amylin is lower in AD patients than in controls [9, 10, 41]. Chronic, peripheral amylin treatment once on daily basis reduced AD pathology in the brain, and improved learning and memory, in AD mouse models [9, 10] [42].…”

“…Amylin easily crosses the blood brain barrier (BBB) [7, 8] and mediates important brain functions. Using AD mouse models, two independent studies demonstrated that treatment with amylin or its clinical analog, pramlintide, reduced AD pathology in the brain and improved learning and memory [9, 10]. A single peripheral injection of amylin or pramlintide result in the transfer of amyloid-β peptide (Aβ) from the brain into the blood in AD mouse models [10] and AD patients [11].…”