Neuroprotective potential of traditionally used medicinal plants of Manipur against rotenone-induced neurotoxicity in SH-SY5Y neuroblastoma cells

Hijam, Aruna Chanu; Tongbram, Yaiphabi Chanu; Nongthombam, Pooja Devi; Meitei, Heikrujam Nilkanta; Koijam, Arunkumar Singh; Rajashekar, Yallapa; Haobam, Reena

doi:10.1016/j.jep.2024.118197

Journal of Ethnopharmacology

2024

DOI: 10.1016/j.jep.2024.118197

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Neuroprotective potential of traditionally used medicinal plants of Manipur against rotenone-induced neurotoxicity in SH-SY5Y neuroblastoma cells

Aruna Chanu Hijam,

Yaiphabi Chanu Tongbram,

Pooja Devi Nongthombam

et al.

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2024

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Cited by 2 publications

References 85 publications

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Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells-a prospect for the development of herbal nutraceuticals

Hijam,

Tongbram,

Nongthombam

et al. 2024

Neurochemistry International

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Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells-a prospect for the development of herbal nutraceuticals

Hijam,

Tongbram,

Nongthombam

et al. 2024

Neurochemistry International

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Natural Products and Their Neuroprotective Effects in Degenerative Brain Diseases: A Comprehensive Review

Lim,

Lee,

Lee

et al. 2024

IJMS

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As the global population ages, the incidence of neurodegenerative diseases such as Alzheimer’s and Parkinson’s is rapidly rising. These diseases present a significant public health challenge, as they severely impair cognitive and motor functions, ultimately leading to a substantial reduction in quality of life and placing a heavy burden on healthcare systems worldwide. Although several therapeutic agents have been developed to manage the symptoms of these diseases, their effectiveness is often limited, and there remains an urgent need for preventive strategies. Growing evidence indicates that bioactive compounds from natural products possess neuroprotective properties through antioxidant and anti-inflammatory effects, modulating key pathways such as phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) and brain-derived neurotrophic factor–tropomyosin receptor kinase B–cAMP response element-binding protein (BDNF-TrkB-CREB), which are crucial for neuronal survival. These compounds may also reduce amyloid-beta and tau pathology, as well as enhance cholinergic neurotransmission by inhibiting acetylcholinesterase activity. By targeting oxidative stress, neuroinflammation, and neurodegeneration, natural products offer a promising approach for both prevention and treatment. These findings suggest that natural products may be promising for preventing and treating neurodegenerative diseases. This review aims to explore the pathogenesis of neurodegenerative diseases, the limitations of current therapies, and the potential role of natural products as therapeutic agents.

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Neuroprotective potential of traditionally used medicinal plants of Manipur against rotenone-induced neurotoxicity in SH-SY5Y neuroblastoma cells

Cited by 2 publications

References 85 publications

Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells-a prospect for the development of herbal nutraceuticals

Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells-a prospect for the development of herbal nutraceuticals

Natural Products and Their Neuroprotective Effects in Degenerative Brain Diseases: A Comprehensive Review

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