Neuroscience: A Sleep Rhythm with Multiple Facets

Koo, Ping Chai; Marshall, Lisa

doi:10.1016/j.cub.2016.07.027

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…Variability in efficacy of weak electric stimulation using similar experimental designs has been frequently commented on, with deviations suggested to arise from slight differences in stimulation parameters, cognitive task, subject population and/or unidentified inter‐individual factors (Marshall & Born, ; Berryhill, ; Herrmann et al ., ; Wiethoff et al ., ; Chew et al ., ; Li et al ., ; Koo & Marshall, ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of slow oscillatory‐transcranial direct current stimulation on EEG and memory – contribution of an inter‐individual factor

Koo

Mölle

Marshall

2018

Eur J of Neuroscience

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Despite many reports on beneficial effects of anodal slow oscillatory-transcranial direct current stimulation (so-tDCS) during non-rapid eye movement (NREM) sleep on memory consolidation, frequent negative outcomes have also been observed. Our working hypothesis is that so-tDCS efficacy is strongly dependent upon the susceptibility of the underlying network. One component determining susceptibility of the network is hypothesized to be reflected in learning or 'task-induced' plastic changes. Another component is hypothesized to represent inter-individual confounds. Twenty-five (15 female) healthy students participated in two learning conditions with and without so-tDCS during early nocturnal NREM sleep and in one control condition without learning tasks. So-tDCS was applied in five 5-min blocks. EEG was assessed during two time windows: an acute period with five 1-min epochs after each stimulation block and a 150-min post-stimulation time period. Inter-individual differences were assessed by a memory quotient (MQ) and subjects classified into high- vs. low-scoring groups. Although so-tDCS was efficient in enhancing fast spindle parameters in the 150-min time period in all subjects, so-tDCS failed to modulate memory consolidation. In contrast, in subjects with a high MQ, memory retention on a figural paired-associate task was significantly increased after so-tDCS. Task-induced slow spindle density was modulated in the opposite direction in subjects with high vs. low MQ being increased in the high-MQ group only. Effects of so-tDCS on EEG were limited to fast spindle modulations in both time windows. These results reveal that inter-individual confound can impact so-tDCS efficacy, suggesting potential use of such factors as biomarkers.

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Section: Introductionmentioning

confidence: 99%

Efficacy of slow oscillatory‐transcranial direct current stimulation on EEG and memory – contribution of an inter‐individual factor

Koo

Mölle

Marshall

2018

Eur J of Neuroscience

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“…For instance, optogenetically driven activation of cholinergic neurons influences the theta-to-slow oscillation ratio (132), and noradrenergic neurons fire phasically time-locked to the slow oscillation (37). These interdependencies may help explain why imposing a stereotyped external rhythm may not always be functionally efficient (61).…”

Section: Figure 2 Active Systems Consolidation and Reactivationmentioning

confidence: 99%

“…Third, results from weak electric stimulation interventions show the greater need to focus on interindividual response variability (61,62). Advances in analysis procedures have facilitated the application of tools to measure features of neural oscillations, such as the phase coupling between slow oscillations and sleep spindles, at the individual subject level.…”

Section: The Role Of Brain Oscillations For Sleep-related Memory Consolidation: Interactions Between Models and Future Directionsmentioning

confidence: 99%

Brain Rhythms During Sleep and Memory Consolidation: Neurobiological Insights

et al. 2020

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Sleep can benefit memory consolidation. The characterization of brain regions underlying memory consolidation during sleep, as well as their temporal interplay, reflected by specific patterns of brain electric activity, is surfacing. Here, we provide an overview of recent concepts and results on the mechanisms of sleep-related memory consolidation. The latest studies strongly impacting future directions of research in this field are highlighted.

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“…Interestingly, we did not find any associations between sleep and PCSS for the older youth, indicating that the younger children were driving the significant associations for the group as a whole. Given that sleep is neuroprotective and necessary for learning and synaptic plasticity (Eugene and Masiak, 2015;Sabir et al, 2015;Koo and Marshall, 2016), these postconcussion changes in sleep and wakefulness are an important issue for children and youth with vulnerable and developing brains.…”

Section: Discussionmentioning

confidence: 99%

A Longitudinal Investigation of Sleep and Daytime Wakefulness in Children and Youth With Concussion

et al. 2019

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A high proportion of adults who sustain a concussion identify changes in their sleep during the acute stage, typically reporting an increased need for sleep or nonrestful sleep. Our understanding of sleep following concussion is less well understood within a pediatric population. In this study, we investigated the trajectory of sleep and daytime sleepiness in a prospective cohort of 40 children and youth (6–18 years old) with concussion, 40 age-and sex-matched healthy children and youth, and 40 with upper-extremity orthopedic injury. Evaluations occurred during the acute stage (<2 weeks) and at 3-, 6-, and 12-month postinjury using the Sleep Disturbance Scale for Children and the Postconcussion Symptom Scale. There were no significant differences within- or between-group differences in sleep across all four time points with analysis of the groups as a whole. When groups were divided by age (6–11 and 12– < 18 years), there was a significant difference in the ability to initiate sleep for the younger concussed group during the acute stage, compared with healthy controls, as well as significantly greater daytime nap duration that decreased over time. Significant correlations were also found between the frequency and duration of daytime naps and Postconcussion Symptom Scale total score and subscores (cognitive, physical/migraine, mood, and sleep) in the concussed group during the acute stage. Our results suggest that in a group with noncomplicated concussion, children and youth have transient alterations in daytime sleepiness that are related to concussion symptoms. Younger children may be more vulnerable to disturbances in sleep and daytime wakefulness.

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Neuroscience: A Sleep Rhythm with Multiple Facets

Cited by 7 publications

References 20 publications

Efficacy of slow oscillatory‐transcranial direct current stimulation on EEG and memory – contribution of an inter‐individual factor

Efficacy of slow oscillatory‐transcranial direct current stimulation on EEG and memory – contribution of an inter‐individual factor

Brain Rhythms During Sleep and Memory Consolidation: Neurobiological Insights

A Longitudinal Investigation of Sleep and Daytime Wakefulness in Children and Youth With Concussion

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