Neuroscience Application Of Interactive Image Analysis

Toga, Arthur W.; Goo, Robert; Murphy, Robert F.; Collins, Ruth

doi:10.1117/12.7973278

Cited by 19 publications

(6 citation statements)

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“…An overdose of barbiturate was used to kill DGinjected animals at 50 min and glucose-injected animals at 10 min. Brains were processed for autoradiography and quantitative image analysis, as previously described for our laboratory (Toga et al, 1984).…”

Section: Preparation Of Animalsmentioning

confidence: 99%

Cerebral Glucose Utilization: Comparison of [¹⁴C]Deoxyglucose and [6‐¹⁴C]Glucose Quantitative Autoradiography

Collins

McCandless

Wagman

1987

Journal of Neurochemistry

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The [14C]deoxyglucose [Sokoloff et al., J. Neurochem. 28, 897-916 (1977)] and [6-14C]glucose [Hawkins et al., Am. J. Physiol. 248, C170-C176 (1985)] quantitative autoradiographic methods were used to measure regional brain glucose utilization in awake rats. The spatial resolution and qualitative appearance of the autoradiograms were similar. In resting animals, there was no significant difference between the two methods among 18 gray and three white matter structures over a fourfold range in glucose utilization rates (coefficient of correlation = 0.97). In rats given increasing frequencies of photoflash visual stimulation, the two methods gave different results for glucose utilization within visual pathways. The linearity of the metabolic response was studied in the superior colliculus using an on-off checkerboard stimulus between 0 and 33 Hz. The greatest increment in activity occurred between 0 and 4 Hz stimulation with both methods, probably representing recruitment of neuronal elements into activity. Above 4 Hz, there was a progressive increase in labeling with [14C]deoxyglucose up to 1.7 times control at 33 Hz. With [6-14C]-glucose, there was no further increment in change above a 30% increase seen at 4 Hz. Measurement of tissue glucose revealed no drop in the visually stimulated structures compared to control. We interpret these results to indicate that, with increasing rates of physiological activity, the products of deoxyglucose metabolism accumulate progressively, but the products of glucose metabolism are removed from brain in 10 min.

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Section: Preparation Of Animalsmentioning

confidence: 99%

Cerebral Glucose Utilization: Comparison of [¹⁴C]Deoxyglucose and [6‐¹⁴C]Glucose Quantitative Autoradiography

Collins

McCandless

Wagman

1987

Journal of Neurochemistry

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“…This technology has been widely employed in studies of metabolism and receptor distributions in the brain 29 but has not been applied previously to myocardium, owing in part to the low concentrations of receptors in cardiac tissues.…”

Section: Discussionmentioning

confidence: 99%

Quantitative autoradiographic delineation of the distribution of beta-adrenergic receptors in canine and feline left ventricular myocardium.

Murphree¹,

Saffitz²

1987

Circulation Research

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“…The goal was to understand the relationship between brain structure and function using image data. Quantitative image analysis was in its infancy and the computational approaches we developed resulted in software programs with wide distribution to the neuroscientific community [4]- [6]. Publications derived from that effort paved the way for sophisticated image reconstruction and visualization approaches in functional activation studies in animal models [7]- [11].…”

Section: History Of the Laboratory Of Neuro Imagingmentioning

confidence: 99%

The laboratory of neuro imaging: what it is, why it is, and how it came to be

Toga

2002

IEEE Trans. Med. Imaging

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Neuroscience Application Of Interactive Image Analysis

Cited by 19 publications

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Cerebral Glucose Utilization: Comparison of [¹⁴C]Deoxyglucose and [6‐¹⁴C]Glucose Quantitative Autoradiography

Cerebral Glucose Utilization: Comparison of [¹⁴C]Deoxyglucose and [6‐¹⁴C]Glucose Quantitative Autoradiography

Quantitative autoradiographic delineation of the distribution of beta-adrenergic receptors in canine and feline left ventricular myocardium.

The laboratory of neuro imaging: what it is, why it is, and how it came to be

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Neuroscience Application Of Interactive Image Analysis

Cited by 19 publications

References 0 publications

Cerebral Glucose Utilization: Comparison of [14C]Deoxyglucose and [6‐14C]Glucose Quantitative Autoradiography

Cerebral Glucose Utilization: Comparison of [14C]Deoxyglucose and [6‐14C]Glucose Quantitative Autoradiography

Quantitative autoradiographic delineation of the distribution of beta-adrenergic receptors in canine and feline left ventricular myocardium.

The laboratory of neuro imaging: what it is, why it is, and how it came to be

Contact Info

Product

Resources

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Cerebral Glucose Utilization: Comparison of [¹⁴C]Deoxyglucose and [6‐¹⁴C]Glucose Quantitative Autoradiography

Cerebral Glucose Utilization: Comparison of [¹⁴C]Deoxyglucose and [6‐¹⁴C]Glucose Quantitative Autoradiography