The current research attempted to integrate Ibn Sina's universal language theory and neuroscience in the development of learning media. It adopted a qualitative library method, with data collected from literature related to universal language theory, neuroscience, and the development of learning materials of Ibn Sina through manual and digital searches for relevant references. The data collected was analyzed by using content analysis which encompassed the data reduction, presentation, and the synthesis of new and comprehensive conceptual frameworks. The results showed that Ibn Sina’s universal language theory offered valuable insights into the significance of language in communication and cognition. Neuroscience provided an understanding of how the human brain processes information and learns. The concepts associated with Ibn Sina's universal language theory and neuroscience, including elements, such as signs, meaning, and relationship between language and reality, were explored to examine their influence on learning media development. The understanding of the principles of human brain-based learning, based on the results of neuroscience, served as a foundation for effective learning media development. By integrating these attributes, the development of learning materials incorporated the conveyance of information in harmony with universal language comprehension and brain-based learning principles. Therefore, learning material developers and teachers should create instructional methods in accordance with advancements in science and technology.