Neuroselective transcutaneous electric stimulation reveals body area–specific differences in itch perception

N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients

“…The neuroselective transcutaneous electrical stimulator, Neurometer ® CPT (Neurotron Inc., Baltimore, MD, USA), is a useful tool that was recently created to assess the threshold for itch sensation noninvasively 13. To investigate the differences between the PEA/AEA emollient and a traditional emollient, we measured and compared the difference in skin barrier function and current perception threshold (CPT) in AE patients.…”

Diferenças de gênero no limiar sensitivo para estimulação elétrica nervosa em adultos jovens

“…[1][2][3][4][5] Particularly in rehabilitation medicine, as the main analgesic and non-pharmacological therapeutic methods, such as electrotherapy, thermotherapy (including cryotherapy) and phototherapy, depend directly on the sensorimotor pathways and on their adaptability. [1][2][3][4][5][6][7] To this effect, the evaluation of the sensory perception threshold (ST), that is, the lower quantity of energy capable of evoking a perception, and of the tolerance threshold (TT), the higher quantity of energy tolerated before pain, are essential measurements for studies of the superficial, thermal tactile and painful sensory pathways. 1,2 Recent investigations have evidenced that the NSS can undergo direct and indirect influences of various endogenous and exogenous physical and chemical factors for the regulation of sensory perception and of pain thresholds.…”

“…[1][2][3][4] The discovery that the circulating levels of sex hormones (SH), especially estrogen E2 and progesterone P2, besides the reproductive 8 and cardioprotective 9 roles, can exercise modulatory effects on the neuronal functions and alter the superficial cutaneous sensitivity 1,2 , gave rise to intriguing questions about the parameters of conformation/therapeutic modulation in analgesia in both genders, particularly in associations with thermal resources. [5][6][7][8][9][10][11] Considering that transcutaneous electrical nerve stimulation (TENS) appears as one of the most reliable and effective non-pharmacological resources for analgesia [3][4][5][6][7][10][11][12][13][14][15] , it became worth investigating the variations of the NSS between genders, and whether previous changes in skin temperature induced by heating/cooling would interfere in the adjustment/peripheral control of the NSS. Recently, experimental and clinical investigations showed that there are differences in the perception of the nociceptive stimulus, in the pain tolerance threshold and in cutaneous sensitivity to electrical stimuli between genders.…”

Neuroselective transcutaneous electrical stimulation reveals neuronal sensitization in atopic dermatitis

“…3 On the other hand, there is growing evidence for the existence of histamine-independent types of itch fibers. [4][5][6][7] This new class of pruriceptors is mechanosensitive with a low electrical threshold and is not linked to the generation of the axon-reflex flare. 4,5 Recently, we demonstrated that a commercially available neuroselective transcutaneous electrical stimulator (NTES) (Neurometer, Neurotron Inc, Baltimore, MD) can provoke itch in healthy individuals and that there are body areaespecific differences in the itch sensation induced by the NTES.…”

“…[4][5][6][7] This new class of pruriceptors is mechanosensitive with a low electrical threshold and is not linked to the generation of the axon-reflex flare. 4,5 Recently, we demonstrated that a commercially available neuroselective transcutaneous electrical stimulator (NTES) (Neurometer, Neurotron Inc, Baltimore, MD) can provoke itch in healthy individuals and that there are body areaespecific differences in the itch sensation induced by the NTES. 4 The NTES-evoked itch sensation is not accompanied by an axon-reflex flare, suggesting that it is mediated through mechanosensitive pruriceptors.…”