Neurospecific fabrication and toxicity assessment of a PNIPAM nanogel encapsulated with trans-tephrostachin for blood-brain-barrier permeability in zebrafish model
“…Oxytocin was released and explicitly bound to upregulated oxytocin receptor and thus inhibiting the microglial activation and reducing the inflammatory cytokine levels (Ye et al 2022 ). Numerous other recent studies have been reported showing the potential of nanogel-based theranostics for CNS diseases and delivery across blood–brain barrier (Arjun et al 2022 ; Vdovchenko 2022 ; Vinogradov et al 2004 ). Fig.…”
Section: Nanogel-based Theranostics For Cns Diseases and Delivery Acr...mentioning
Here in the present article, the state of art for nanotechnology-enabled nanogel theranostics and the upcoming concepts in nanogel-based therapeutics are summarized. The benefits, innovation, and prospects of nanogel technology are also briefly presented.
“…Oxytocin was released and explicitly bound to upregulated oxytocin receptor and thus inhibiting the microglial activation and reducing the inflammatory cytokine levels (Ye et al 2022 ). Numerous other recent studies have been reported showing the potential of nanogel-based theranostics for CNS diseases and delivery across blood–brain barrier (Arjun et al 2022 ; Vdovchenko 2022 ; Vinogradov et al 2004 ). Fig.…”
Section: Nanogel-based Theranostics For Cns Diseases and Delivery Acr...mentioning
Here in the present article, the state of art for nanotechnology-enabled nanogel theranostics and the upcoming concepts in nanogel-based therapeutics are summarized. The benefits, innovation, and prospects of nanogel technology are also briefly presented.
“…Oral drug administration in zebrafish models is a common method used to study the pharmacokinetics and pharmacodynamics of various compounds [131][132][133]. Food-based drug delivery systems involve encapsulating drugs or therapeutic agents within feed pellets or microcapsules that are consumed voluntarily by adult zebrafish [134,135].…”
Neurological diseases, including neurodegenerative and neurodevelopmental disorders, affect nearly one in six of the world’s population. The burden of the resulting deaths and disability is set to rise during the next few decades as a consequence of an aging population. To address this, zebrafish have become increasingly prominent as a model for studying human neurological diseases and exploring potential therapies. Zebrafish offer numerous benefits, such as genetic homology and brain similarities, complementing traditional mammalian models and serving as a valuable tool for genetic screening and drug discovery. In this comprehensive review, we highlight various drug delivery techniques and systems employed for therapeutic interventions of neurological diseases in zebrafish, and evaluate their suitability. We also discuss the challenges encountered during this process and present potential advancements in innovative techniques.
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