2018
DOI: 10.1111/jne.12502
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Neurosteroidogenesis and progesterone anti‐inflammatory/neuroprotective effects

Abstract: Progesterone shows anti-inflammatory and promyelinating effects in mice with experimental autoimmune encephalomyelitis (EAE), a commonly used model for multiple sclerosis (MS). Because neurosteroids have been implicated as protective factors for MS and EAE, we analysed the expression of neurosteroidogenic enzymes in the compromised spinal cord of EAE mice. EAE was induced in female C57Bl6 mice, which were then killed on day 16 after induction. Progesterone was given by pellet implantation 1 week before EAE ind… Show more

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Cited by 52 publications
(30 citation statements)
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“…In addition to the cuprizone model, the effectiveness of progesterone and 3α,5α-THPROG has been reported in the experimental autoimmune encephalomyelitis (EAE) model. In this model, progesterone showed promyelinating, neuroprotective, and anti-inflammatory effects, as recently reviewed [123]. In addition, the selective progesterone agonist Nestorone improved functional outcomes, increased neurogenesis, and decreased inflammation in the brains of female EAE mice [124].…”
Section: Neuroprotective Effects In Neurodegenerative Diseases Modelsmentioning
confidence: 75%
“…In addition to the cuprizone model, the effectiveness of progesterone and 3α,5α-THPROG has been reported in the experimental autoimmune encephalomyelitis (EAE) model. In this model, progesterone showed promyelinating, neuroprotective, and anti-inflammatory effects, as recently reviewed [123]. In addition, the selective progesterone agonist Nestorone improved functional outcomes, increased neurogenesis, and decreased inflammation in the brains of female EAE mice [124].…”
Section: Neuroprotective Effects In Neurodegenerative Diseases Modelsmentioning
confidence: 75%
“…Since progesterone and its derivates promote myelin formation in the peripheral nervous system, the role that they might play in demyelinating diseases has received attention for many years. In EAE mice, progesterone itself and one of its reduced metabolites, allopregnanolone, have been shown to reduce inflammatory markers, to inhibit microglia activation and to avoid the penetration of circulating lymphocytes and macrophages in the central nervous system (CNS) (De Nicola et al, 2013 , 2017 ; Noorbakhsh et al, 2014 ). This reduction in neuroinflammatory processes would mediate, at least in part, the beneficial effects of progesterone in EAE mice, which show reduced clinical severity, lower demyelination and improved neuronal function after progesterone treatment (Garay et al, 2007 , 2009 ).…”
Section: Introductionmentioning
confidence: 99%
“…Several years ago, it was shown that neuronal and glial cells are able to synthesize progesterone de novo from cholesterol and its metabolites (Tsutsui et al, ; Schumacher et al, ). In this context, cytochrome P450 side‐chain cleavage enzyme and 3β‐hydroxysteroid‐dehydrogenase are key enzymes, which are needed for the endogenous synthesis (De Nicola et al, ). Many effects of progesterone are mediated by genomic mechanisms of PR.…”
Section: Progesterone and Prsmentioning
confidence: 99%