Neurotoxicity and Immunotherapy

Kopecký, J

doi:10.14735/amko202011

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…A partir da seleção e análise dos 17 artigos, fica evidente que a imunoterapia é uma alternativa promissora, quando comparada aos tratamentos clássicos [8][9][10][11] , uma vez que possui alta eficácia, é menos invasiva e proporciona melhor prognóstico pautado na resposta clínica, na taxa de sobrevivência e na progressão da doença, sendo que em casos iniciais, esses benefícios podem ser ainda maiores.…”

Section: Resultsunclassified

Aplicação Da Imunoterapia No Sus: Impactos Éticos E Financeiros

ALENCAR

BISSOLI

HANSEN

et al. 2022

RMP

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RESUMO - Dados do Instituto Nacional do Câncer estimam que o Brasil terá 625 mil novos casos de câncer a cada ano do triênio 2020-2022. O Brasil, único país da América Latina com um sistema universal de saúde, apresentou grande avanço no tratamento do câncer. Nesse ínterim inclui-se a imunoterapia. Entretanto, o desafio ainda é longo e de custo muito elevado assim, o objetivo desta revisão foi discutir acerca da disponibilidade geral de imunoterapia no SUS. Assim, foi realizda pesquisa bibliográfica no Pubmed e Scielo com os descritores “Imunoterapia”, “Sistema Único de Saúde” e “Oncologia”. Selecionou-se 17 artigos. Em conclusão, a partir da incorporação da imunoterapia no SUS, estima-se aumento considerável na sobrevida. Todavia, a carência da disponibilidade orçamentária atrasa a implementação do tratamento. Ademais, são necessárias mais pesquisas e novas formas de seleção dos pacientes para a disponibilidade do tratamento a fim de não prejudicar o sistema público.

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Section: Resultsunclassified

Aplicação Da Imunoterapia No Sus: Impactos Éticos E Financeiros

ALENCAR

BISSOLI

HANSEN

et al. 2022

RMP

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Synthesis, Characterization, Antiproliferative Activity of Galloyl Derivatives and Investigation of Cytotoxic Properties in HepG2/C3A Cells

Santos

Freitas

Foglio

et al. 2022

CPB

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Background: Appropriate substituents in the galloyl group could lead to significant biological properties. Objective: Novel galloyl-substituted compounds bearing 2-substituted-1,3,4-oxadiazol-5-yl, 5-substituted-1,2,4-triazol-3-yl, and carboxamide groups were synthesized and evaluated for their antiproliferative activity. Additionally, galloyl hydrazide (2) was evaluated by performing cytotoxicity, membrane integrity, cell cycle, and apoptosis assays in HepG2/C3A cells. Method: General procedure was used for the synthesis of galloyl-substituted (3-9, 11) and characterized by their spectroscopic data (1H and 13C NMR). The antiproliferative activity of all novel galloyl derivatives was evaluated against nine human tumors and one nontumoral cell line. Three response parameters (GI50, TGI, and LC50) were calculated. The cytotoxicity test was performed for the resazurin assay. The membrane integrity, cell cycle, and apoptosis assays were performed by flow cytometry. Results: The substitution of the methoxy group of the galloyl ring system for a carboxamide group (3, 4, 5, and 6) produced compounds with moderate antitumoral activity, particularly 6, against six human cancer cell lines, K-562, PC-3, NCI-ADR/RES, OVCAR, 786-0 and NCI-H460, with GI50 values ≤ 9.45 µg/mL. Triazole derivatives 7 and 8 exhibited higher antitumoral activity toward OVCAR, MCF-7 and leukemia K-562 cell lines, exhibiting GI50 values less than 10 µg/mL. Compound 11 displayed significant activity against PC-3 (GI50 = 4.31 µg/mL), OVCAR (GI50 = 8.84 µg/mL) and K-562 (GI50 = 8.80 µg/mL) cell lines. Galloyl hydrazide (2) had cytotoxic activity in HepG2/C3A cells (IC50 = 153.7 µg/mL). In membrane permeability, cell count, cell cycle, and apoptosis assays, as determined using the IC50 of compound (2) in HepG2/C3A cells, increased membrane permeability, decreased cell count, altered cell cycle, and initial apoptosis was observed compared to the control group. Conclusion: Thus, our results showed for the first time the synthesis, antiproliferative activity, and cytotoxicity of galloyl-substituted compounds. Galloyl-substitution does not have a very strong synergistic effect in the inhibition of cancer cell proliferation compared with galloyl hydrazide (2). Compound 2 demonstrated promising activity in HepG2/C3A hepatocarcinoma cells.

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Neurotoxicity and Immunotherapy

Cited by 2 publications

References 11 publications

Aplicação Da Imunoterapia No Sus: Impactos Éticos E Financeiros

Aplicação Da Imunoterapia No Sus: Impactos Éticos E Financeiros

Synthesis, Characterization, Antiproliferative Activity of Galloyl Derivatives and Investigation of Cytotoxic Properties in HepG2/C3A Cells

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