Neurotransducers Based Voltage Sensitive Dye-Doped Microlasers

Manzo, Maurizio; Cavazos, Omar

doi:10.1364/boda.2019.jt4a.14

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…Lastly, 20 papers were used to introduce the WGM and the hybrid WGM sensing [34,35,[40][41][42][50][51][52][53][54][55][56][57][58][59][60][61][62][63]. This type of sensing methodology was not directly related to the medical literature, but biomedical applications were proposed and the future implementation of this method is likely to become the gold standard in some areas.…”

Section: Resultsmentioning

confidence: 99%

“…WGM resonators have been used for different applications, especially for high-sensitivity and resolution sensors [40,[50][51][52][53][54][55]. The WGM microstructure can be made in various types of shapes such as spheres, cylinders, and toroid [40,[50][51][52][53][54][55]. The WGMs of the resonator can be observed by coupling light to the resonator.…”

Section: Hybrid Whispering Gallery Mode Sensorsmentioning

confidence: 99%

“…The WGM resonances can be observed using different techniques. For example, a study used a charge-coupled device camera and a spectrometer to observe the resonances, and therefore when doping WGM resonators with a laser dye material, the hybrid functions as tiny lasers that emit light under proper excitation conditions [40,[50][51][52][53][54][55]67]. The light emitted from the resonator could then be coupled into the spectrometer using an optical lens setup [40].…”

Section: Hybrid Whispering Gallery Mode Sensorsmentioning

confidence: 99%

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Plasmonic and Hybrid Whispering Gallery Mode–Based Biosensors: Literature Review

Manzo¹,

Cavazos²,

Huang³

et al. 2021

JMIR Biomed Eng

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Background The term “plasmonic” describes the relationship between electromagnetic fields and metallic nanostructures. Plasmon-based sensors have been used innovatively to accomplish different biomedical tasks, including detection of cancer. Plasmonic sensors also have been used in biochip applications and biosensors and have the potential to be implemented as implantable point-of-care devices. Many devices and methods discussed in the literature are based on surface plasmon resonance (SPR) and localized SPR (LSPR). However, the mathematical background can be overwhelming for researchers at times. Objective This review article discusses the theory of SPR, simplifying the underlying physics and bypassing many equations of SPR and LSPR. Moreover, we introduce and discuss the hybrid whispering gallery mode (WGM) sensing theory and its applications. Methods A literature search in ScienceDirect was performed using keywords such as “surface plasmon resonance,” “localized plasmon resonance,” and “whispering gallery mode/plasmonic.” The search results retrieved many articles, among which we selected only those that presented a simple explanation of the SPR phenomena with prominent biomedical examples. Results SPR, LSPR, tilted fiber Bragg grating, and hybrid WGM phenomena were explained and examples on biosensing applications were provided. Conclusions This minireview presents an overview of biosensor applications in the field of biomedicine and is intended for researchers interested in starting to work in this field. The review presents the fundamental notions of plasmonic sensors and hybrid WGM sensors, thereby allowing one to get familiar with the terminology and underlying complex formulations of linear and nonlinear optics.

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Section: Resultsmentioning

confidence: 99%

Section: Hybrid Whispering Gallery Mode Sensorsmentioning

confidence: 99%

Section: Hybrid Whispering Gallery Mode Sensorsmentioning

confidence: 99%

See 1 more Smart Citation

Plasmonic and Hybrid Whispering Gallery Mode–Based Biosensors: Literature Review

Manzo¹,

Cavazos²,

Huang³

et al. 2021

JMIR Biomed Eng

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“…Recently, WGM optical neurotransducers for the detection of neuron activities have been proposed by Manzo et al [22,23]. These neurotransducers are polymeric microlasers doped with a voltage sensitive dye.…”

Section: Introductionmentioning

confidence: 99%

“…These neurotransducers are polymeric microlasers doped with a voltage sensitive dye. A voltage sensitive dye (VSD) is used to detect neuron activity via perturbation of the device's evanescent field, which in turn causes a shift in the laser (optical) modes (WGMs), also eliminating the need for the VSD to be embedded into a cellular membrane [22,23]. Due to this and other sensitive applications, there is the need to fabricate and precisely control the polymeric microlaser size.…”

Section: Introductionmentioning

confidence: 99%

Solid State Optical Microlasers Fabrication via Microfluidic Channels

Manzo

Cavazos

2020

Optics

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In this paper, we propose the use of a microfluidic channel with flow focusing technique to fabricate solid state polymeric microlasers to precisely control sizes for mass production. Microlasers are made from a solution of UV curable polymer, namely polyethylene glycol diacrylate (PEGDA) with a molecular weight of 700 and rhodamine 6G laser dye at two different volumetric ratios (polymer to dye) of 4:1 and 2:1, respectively, which are used as the dispersed phase. A reservoir filled with liquid polydimethylsiloxane (PDMS) was used to cure the microlasers via UV lamp. A microchannel made of (PDMS) and size of 200 µm was used in this paper; mineral oil was selected as the continuous phase. Two experiments are conducted by fixing the pressure flow for the dispersed phase to 188 mbar and 479.9 mbar, respectively. In both experiments, the pressure of the continuous phase (mineral oil) was varied between 1666.9 mbar and 1996.9 mbar. The measurement of the fabricated microlasers’ size was performed with the aid of the MATLAB Image Processing Toolbox by using photographs taken with a CMOS camera. The tunability of the highest size, ranging from 109 µm to 72 µm, was found for the PEGDA to dye ratio of 2:1 (188 mbar) and average standard deviation of 1.49 µm, while no tunability was found for the 4:1 ratio (188 mbar). The tunability of the microlaser’s size, ranging from 139 µm to 130 µm and an average standard deviation value of 1.47 µm, was found for the 4:1 ratio (479.9 mbar). The fabricated microlasers presented a quality factor Q of the order 104, which is suitable for sensing applications. This technique can be used to control the size of the fabrication of a high number of solid state microlaser based UV polymers mixed with laser dyes.

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Monitoring of pressurized pipelines with whispering gallery mode-based sensors

Rubino,

Agarwal

2024

Photonic Instrumentation Engineering XI

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The purpose of this work is to explore the use of optical resonators based on the Whispering Gallery Mode phenomenon (WGM), to determine the variation of the internal pressure of a pipeline due to leaks. Numerical experiments were performed to determine the sensitivity of disk-shaped optical resonators embedded in the wall of the pipe. A change in the internal pressure causes mechanical stress in the pipe wall and therefore a strain that is transferred to the optical resonator. This strain can be related to the shift of the optical modes (WGM shift) to determine the sensitivity of the sensor. The parameters investigated include the size of the resonator and the location within the thickness of the pipe wall. The results show a linear behavior of the WGM shift with the applied pressure, as well as a quadratic increase of the sensitivity with the resonator diameter.

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Neurotransducers Based Voltage Sensitive Dye-Doped Microlasers

Cited by 5 publications

References 5 publications

Plasmonic and Hybrid Whispering Gallery Mode–Based Biosensors: Literature Review

Plasmonic and Hybrid Whispering Gallery Mode–Based Biosensors: Literature Review

Solid State Optical Microlasers Fabrication via Microfluidic Channels

Monitoring of pressurized pipelines with whispering gallery mode-based sensors

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