2008
DOI: 10.1002/ajmg.b.30632
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Neurotrophic factor‐related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high‐risk male population

Abstract: Adult attention deficit hyperactivity disorder (ADHD) is a widely under-reported but nevertheless common condition with a clear heritable component. Several genes have been proposed to play a role in the childhood onset of this neurodevelopmental disorder; however, association studies of persistence of ADHD into adulthood have rarely been performed. Neurotrophic factors (NTFs) are known to be involved in several aspects of neuronal development and neural plasticity in adults. They have also been linked, partic… Show more

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Cited by 33 publications
(29 citation statements)
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“…Especially in patients with mild AD, the conflicting instructions score was significantly lower in the G allele carriers than in the subjects with an A/A genotype (table 4b). Such results indicating a predominance of A/A genotypes compared to G carriers with regard to neurocognition may support the results of previous studies, in which the NT-3 gene was found to be associated with the intelligence of individuals with ADHD, who exhibit neuropsychological attentional deficits linked to social cognitive impairments as core symptoms [23,24]. We could not find a significant association among the rs6489630 genotypes and executive function in patients with mild-stage AD or A-MCI.…”
Section: Discussionsupporting
confidence: 78%
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“…Especially in patients with mild AD, the conflicting instructions score was significantly lower in the G allele carriers than in the subjects with an A/A genotype (table 4b). Such results indicating a predominance of A/A genotypes compared to G carriers with regard to neurocognition may support the results of previous studies, in which the NT-3 gene was found to be associated with the intelligence of individuals with ADHD, who exhibit neuropsychological attentional deficits linked to social cognitive impairments as core symptoms [23,24]. We could not find a significant association among the rs6489630 genotypes and executive function in patients with mild-stage AD or A-MCI.…”
Section: Discussionsupporting
confidence: 78%
“…Thus, the conflicting instructions mean score and standard deviation (SD) for the A/A group was 3.00 ± 0 (tables 1b, 4b). However, the effect sizes or statistical values were about the same as those in previous reports [23,24]. Thirdly, we used only the FAB to confirm the patients' executive dysfunction in this study.…”
Section: Nt-3 Polymorphisms In Admentioning
confidence: 67%
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