Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment

Owens, Cameron D.; Pinto, Camila Bonin; Mukli, Peter; Gulej, Rafal; Velez, Faddi Saleh; Detwiler, Sam; Olay, Lauren; Hoffmeister, Jordan R.; Szarvas, Zsofia; Muranyi, Mihaly; Peterfi, Anna; Pinaffi‐Langley, Ana Clara da C.; Adams, Cheryl; Sharps, Jason; Kaposzta, Zalan; Prodan, Calin I.; Kirkpatrick, Angelia C.; Tarantini, Stefano; Csiszar, Anna; Ungvari, Zoltan; Olson, Ann L.; Li, Guangpu; Balasubramanian, Priya; Galvan, Veronica; Bauer, Andrew; Smith, Zachary A.; Dasari, Tarun W.; Whitehead, Shawn; Medapti, Manoj R.; Elahi, Fanny M.; Thanou, Aikaterini; Yabluchanskiy, Andriy

doi:10.1002/alz.14072

Alzheimer's & Dementia

2024

DOI: 10.1002/alz.14072

|View full text |Cite

Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment

Cameron D. Owens,

Camila Bonin Pinto,

Peter Mukli

et al.

Abstract: INTRODUCTIONMild cognitive impairment (MCI) is a prodromal stage of dementia. Understanding the mechanistic changes from healthy aging to MCI is critical for comprehending disease progression and enabling preventative intervention.METHODSPatients with MCI and age‐matched controls (CN) were administered cognitive tasks during functional near‐infrared spectroscopy (fNIRS) recording, and changes in plasma levels of extracellular vesicles (EVs) were assessed using small‐particle flow cytometry.RESULTSNeurovascular… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Evaluation of Neurovascular Coupling in Early‐Onset and Late‐Onset Epilepsy of Unknown Etiology

Wan,

Yin,

Chai

et al. 2024

Magnetic Resonance Imaging

View full text Add to dashboard Cite

BackgroundPrevious studies have shown neurovascular coupling (NVC) dysfunction in epilepsy, suggesting its role in the pathological mechanisms. However, it remains unclear whether NVC abnormalities exist in epilepsy of unknown etiology (EU).PurposeTo integrate multiparametric MRI to assess NVC and its relationship with cognition in early‐onset and late‐onset EU patients.Study TypeProspective.PopulationNinety‐six EU patients (46 early‐onset, M/F = 20/26; 50 late‐onset, M/F = 29/21) and 60 healthy controls (HCs, M/F = 25/35).Field Strength/Sequence3.0 T, resting‐state gradient echo‐planar imaging, pseudo‐continuous arterial spin labeling (pc‐ASL), and T1‐weighted brain volume sequence.AssessmentFunctional MRI data were analyzed to assess intrinsic brain activity including amplitude of low‐frequency fluctuations (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), and functional connectivity strength (FCS), while pc‐ASL provided cerebral blood flow (CBF) measurements. Coupling correlation coefficients and ratios of CBF to neural activity were calculated to evaluate global and regional NVC.Statistical TestsTwo‐sample t‐test, Analysis of Variance, Kruskal–Wallis test, Chi‐square test, Analysis of Covariance, family‐wise error/Bonferroni correction, partial correlation analyses. Statistical significance was defined as P < 0.05.ResultsWhole‐brain analysis revealed increased ALFF values in both patient groups' left precentral and postcentral gyri. Both patient groups had lower global NVC coefficients than HCs, with reduced CBF‐ALFF (0.28 vs. 0.30), CBF‐fALFF (0.43 vs. 0.45), and CBF‐ReHo (0.40 vs. 0.41) in early‐onset patients, and lower CBF‐fALFF (0.38 vs. 0.45) and CBF‐ReHo (0.32 vs. 0.41) in late‐onset patients. Regional analysis showed significantly decreased CBF/ALFF ratios in the left precentral and postcentral gyri (T = 3.85 to 5.33). Reduced global NVC in early‐onset patients was significantly associated with poorer executive function (r = 0.323), while global coupling in late‐onset patients was negatively correlated with disease duration (r = −0.348 to −0.426).Data ConclusionThis study showed abnormal global and regional NVC in both early‐onset and late‐onset EU patients, emphasizing the potential role of NVC in the pathophysiological mechanisms of EU.Level of Evidence1Technical EfficacyStage 1

show abstract

Evaluation of Neurovascular Coupling in Early‐Onset and Late‐Onset Epilepsy of Unknown Etiology

Wan,

Yin,

Chai

et al. 2024

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

Cytokine dysregulation in amnestic mild cognitive impairment

Tran-Chi,

Maes,

Nantachai

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The pathophysiology of amnestic Mild Cognitive Impairment (aMCI) is largely unknown, although some papers found signs of immune activation. To assess the cytokine network in aMCI after excluding patients with major depression (MDD) and to examine the immune profiles of quantitative aMCI (qMCI) and distress symptoms of old age (DSOA) scores. A case-control study was conducted on 61 Thai aMCI participants and 60 healthy old adults (both without MDD). The Bio-Plex Pro human cytokine 27-plex test kit was used to assay cytokines/chemokines/growth factors in fasting plasma samples. aMCI is characterized by a significant immunosuppression, and reductions in T helper 1 (Th)1 and T cell growth profiles, the immune-inflammatory responses system, interleukin (IL)1β, IL6, IL7, IL12p70, IL13, GM-CSF, and MCP-1. These 7 cytokines/chemokines exhibit neuroprotective effects at physiologic concentrations. In multivariate analyses, three neurotoxic chemokines, CCL11, CCL5, and CXCL8, emerged as significant predictors of aMCI. Logistic regression showed that aMCI was best predicted by combining IL7, IL1β, MCP-1, years of education (all inversely associated) and CCL5 (positively associated). We found that 38.2% of the variance in the qMCI score was explained by IL7, IL1β, MCP-1, IL13, years of education (inversely associated) and CCL5 (positively associated). The DSOA was not associated with any immune data. An imbalance between lowered levels of neuroprotective cytokines and chemokines, and relative increases in neurotoxic chemokines are key factors in aMCI. Future MCI research should always control for the confounding effects of affective symptoms. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-73099-z.

show abstract

The effectiveness of Tai Chi for patients with mild cognitive impairment: a systematic review and meta−analysis

Shao,

Xi,

Pan

et al. 2024

Front. Neurosci.

View full text Add to dashboard Cite

ObjectiveTo explore the effectiveness of Tai Chi on cognitive function in patients with mild cognitive impairment (MCI).MethodsAccording to the PRISMA guidelines, randomized controlled trial (RCT) literature on the efficacy of Tai Chi on MCI patients was searched in China National Knowledge Network (CNKI), China Biomedical Literature Database (CBM), Wanfang Data, China Scientific Journal Database (VIP), PubMed, Embase, Duxiu Database, Web of Science and Cochrane Library from their inception to April 2024. The risk of bias in each study was appraised using the Cochrane risk−of−bias tool using Revman 5.4. Random effect model or fixed effect model was used to compare the effects of Tai Chi and control conditions on baseline and post−intervention assessment of cognitive function. Meta−analysis was performed using Stata15.0 software.ResultsNine studies fulfilled the inclusion criteria. Tai Chi significantly improved Montreal Cognitive Assessment (MoCA, SMD, 1.43, p < 0.00001), Delayed Recall Test (DRT, SMD, 0.90, p < 0.00001), verbal fluency test (VFT, SMD, 0.40, p < 0.00001), and Trail Making Test (TMT, SDM, −0.69, p < 0.00001) in MCI patients. Subgroup analyses showed that 24-forms Tai Chi was more effective than 8-forms Tai Chi in improving MoCA (SMD, 1.89, p < 0.00001) and 10-forms Tai Chi was more effective than 24-forms Tai Chi in improving DRT (SMD, 1.53, p < 0.00001).ConclusionTai Chi improved cognitive function in MCI patients, and Tai Chi types might be the influence factor on Tai Chi improving the global cognitive function and memory function in MCI patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment

Cited by 3 publications

References 59 publications

Evaluation of Neurovascular Coupling in Early‐Onset and Late‐Onset Epilepsy of Unknown Etiology

Evaluation of Neurovascular Coupling in Early‐Onset and Late‐Onset Epilepsy of Unknown Etiology

Cytokine dysregulation in amnestic mild cognitive impairment

The effectiveness of Tai Chi for patients with mild cognitive impairment: a systematic review and meta−analysis

Contact Info

Product

Resources

About