Neutralization agents for neutralization-reionization mass spectrometry

Danis, Paul O.; Ren, Feng; McLafferty, Fred W.

doi:10.1021/ac00293a019

Cited by 55 publications

(30 citation statements)

References 11 publications

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“…Molecular oxygen is the usual reionization target because of its relatively good efficiency and the soft nature of reionization. 44 Under single-collision conditions (70È90% transmittance) the reionization efficiencies are typically of the order of 10~3, making the overall efficiency of NR The neutralizing and reionizing &I NR /I 0 B 10~5. collisions introduce some side e †ects that interfere with NR.…”

Section: Methodsmentioning

confidence: 99%

Modeling nucleobase radicals in the mass spectrometer

Tureček¹

1998

J. Mass Spectrom.

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Section: Methodsmentioning

confidence: 99%

Modeling nucleobase radicals in the mass spectrometer

Tureček¹

1998

J. Mass Spectrom.

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“…For example, vaporized metals are found to be the most efficient targets for charge exchange neutralization and they yield much less fragmentation than is observed with helium as the target. 45 In the reionization step, oxygen is found to be the most efficient collision gas, and it also minimizes the extent of fragmentation. Therefore, when structural information is desirable, increased target pressure (to maximize collisional excitation) and/or helium gas should be used.…”

Section: Reaction (15) Collisional Ionizationmentioning

confidence: 99%

“…As a rule, the highest precursor ion kinetic energies possible are recommended to minimize losses due to scattering. 45,46 Many NRMS experiments have been performed in the field-free region of a double-focusing mass spectrometer, where neutralization and reionization occur in the same collision cell. This arrangement may lead to ambiguity with respect to the origin of fragments, as they might arise from either neutralized or ionized parent species.…”

Section: Reaction (15) Collisional Ionizationmentioning

confidence: 99%

Charge permutation reactions in tandem mass spectrometry

McLuckey

2004

J. Mass Spectrom.

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Central to the tandem mass spectrometry experiment is the process that gives rise to product ions, i.e. the reaction intermediate to stages of mass analysis. Changes in mass or charge of the parent ion (or both) are generally readily detected by all forms of tandem mass spectrometry. Charge changing, or charge permutation, reactions have a long history in mass spectrometry. However, with the advent of new ionization methods, such as electrospray ionization, and the expansion of tandem mass spectrometry instrumentation to include ion trapping instruments, the past decade has seen a major increase in the types of charge permutation reactions that can be studied. Most charge permutation reactions involve electrons or protons as the charge mediating agents. This report, therefore, provides an overview of charge permutation reactions involving protons or electrons. Particular emphasis is placed on processes that involve interactions of precursor ions with gaseous neutral species, electrons or oppositely charged ions. Charge permutation reactions involving electron gain/loss are described first according to a rough order of the energy required for the reaction beginning with the most endoergic reactions and ending with the most exoergic reactions. An analogous approach is then taken with charge permutation reactions involving proton gain/loss. Important charge permutation reactions discussed herein, among others, include those referred to as charge inversion, charge stripping, electron capture dissociation, collision-induced ionization and charge separation. These reaction types, and others described herein, are the subjects of active research and are also finding use in many current areas of application.

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“…16 The +NR+ spectra of 1 and 2 ( and HCO that dominate the CAD spectrum are much less competitive in the 'NR' spectrum.…”

Section: Resultsmentioning

confidence: 99%

Neutralization‐reionization study of C₆H₆O isomers

Tureček

Drinkwater

Maquestiau

et al. 1989

Org. Mass Spectrom.

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Neutralizatio~reionization (+NR+) mass spectrometry is employed to examine the behavior of C,H,O isomers in the gas phase. Phenol and cyciohexa-2,4-dienone are found not to interconvert following neutralization with mercury of their corresponding cation radicals at 9.9 keV kinetic energy. A very low extent of isomerization is observed following collisional activation of fast C,H,O neutrals with helium. The +NR+ and collisionally activated dissociation spectra, the latter obtained at unit mass resolution, are used to identify these [C6H60]+' isomers. Hexa-l,3,ltrienal is found to cyclize spontaneously to cyclohexa-2,4-dienone during attempted pyrolytic prep aration. The thermochemistry of these C,H,O molecules and cation radicals is discussed on the basis of experimental data and MNDO calculations.

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Neutralization agents for neutralization-reionization mass spectrometry

Cited by 55 publications

References 11 publications

Modeling nucleobase radicals in the mass spectrometer

Modeling nucleobase radicals in the mass spectrometer

Charge permutation reactions in tandem mass spectrometry

Neutralization‐reionization study of C₆H₆O isomers

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Neutralization agents for neutralization-reionization mass spectrometry

Cited by 55 publications

References 11 publications

Modeling nucleobase radicals in the mass spectrometer

Modeling nucleobase radicals in the mass spectrometer

Charge permutation reactions in tandem mass spectrometry

Neutralization‐reionization study of C6H6O isomers

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Neutralization‐reionization study of C₆H₆O isomers