Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: Contributions to understanding snakebite envenomings and their treatment

Lomonte, Bruno; León, Guillermo; Angulo, Yamileth; Rucavado, Alexandra; Núñez, Vitelbina

doi:10.1016/j.toxicon.2009.03.015

Cited by 66 publications

(41 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study showed that the extract of U. chamae was effective in neutralizing the lethality and the effects of Naja nigricollis venom in animals. Several workers have studied the ability of plants as well as their purified fractions to inhibit biological activities of snake venoms (Melo et al, 1994;Maiorano et al, 2005;Oliveira et al, 2005;Cavalcante et al, 2007;Lomonte et al, 2009;Depaula et al, 2010). However, only a few have investigated the neutralizing mechanism of their action.…”

Section: Discussionmentioning

confidence: 99%

IN VIVO NEUTRALIZATION OF NAJA NIGRICOLLIS VENOM BY UVARIA CHAMAE

James

Ebiloma

Otini

2013

American Journal of Biochemistry and Biotechnology

View full text Add to dashboard Cite

Uvaria chamae is a well known medicinal plant in Nigerian traditional medicine for the management of many diseases, but investigations concerning its pharmacological characteristics are rare. In this study, we evaluate its venom neutralizing properties against Naja nigricollis venom in rats. Freshly collected Uvaria chamae leaves were air dried, powdered and extracted in methanol. To study the antivenom properties, albino rats were orally administered with a dose of 400 mg kg −1 body weight and one hour later, the venom was administered intraperitoneally at a dose of 0.08 mg kg −1 body weight of rats. Albino rats (male) weighing between 180-200g were randomly divided into five (5) groups of three (3). Groups 1-5 received water, normal saline, venom, Uvaria chamae and venom, Uvaria chamae respectively. Blood clothing time, bleeding time, antipyretic activity, haemoglobin, RBC, WBC, creatine kinase, AST, ALP and ALT activities total protein antioxidant activity and some blood electrolytes, plasma urea and uric acid were measured. Our results showed that Uvaria chamae methanol extract neutralized some biological effects of Naja nigricollis venom. The venom increased the rectal temperature, enzyme activities, bleeding time and other blood parameters. The plant extract was able to reduce these parameters in the extract treated groups. Details of the results are discussed. From this study, it is clear that U. chamae leaf extract had antivenom activity in animal models. The above results indicate that the plant extract possess potent snake venom neutralizing capacity and could potentially be used for therapeutic purpose in case of snake bite envenomation.

show abstract

Section: Discussionmentioning

confidence: 99%

IN VIVO NEUTRALIZATION OF NAJA NIGRICOLLIS VENOM BY UVARIA CHAMAE

James

Ebiloma

Otini

2013

American Journal of Biochemistry and Biotechnology

View full text Add to dashboard Cite

show abstract

“…A very promising avenue is the possibility of using natural or synthetic inhibitors of venom toxins, such as inhibitors of phospholipases A 2 , metalloproteinases and hyaluronidases, for blocking the action of tissue-damaging toxins by rapidly administering these inhibitors directly on the site of venom injection Lomonte et al, 2009;Perales et al, 2005). Such possibility has been tested, with excellent results, at the preclinical level in mouse models (Borkow et al, 1997;Lomonte et al, 2009;Rucavado et al, 2000;Yingprasertchai et al, 2003). It is necessary to identify and develop inhibitors, some of which may be already in use for other pathologies, and to test them at the preclinical and clinical levels.…”

Section: Ancillary Treatmentsmentioning

confidence: 99%

Snakebite Envenoming: A Public Health Perspective

Gutiérrez¹

2012

Public Health - Methodology, Environmental and Systems Issues

View full text Add to dashboard Cite

“…Several plants have been used in folk medicine throughout the world as treatment against snakebites (Houghton and Osibogun., 1993;Melo et al, 1994;Maiorano et al, 2005;Oliveira et al, 2005;Cavalcante et al, 2007;Lomonte et al, 2009;De Paula et al, 2010;Omale et al, 2013). Till date few plants materials have been evaluated in well controlled assays and only a few of them have been found to be effective against Snake envenomation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ethanolic Leaf Extract of Euphorbia hirta on Snake Venom Induced Toxicity in Mice

Agusi¹,

Ogbunachi²

2018

TJANS

View full text Add to dashboard Cite

Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: Contributions to understanding snakebite envenomings and their treatment

Cited by 66 publications

References 176 publications

<I>IN VIVO</I> NEUTRALIZATION OF <I>NAJA NIGRICOLLIS</I> VENOM BY <I>UVARIA CHAMAE</I>

<I>IN VIVO</I> NEUTRALIZATION OF <I>NAJA NIGRICOLLIS</I> VENOM BY <I>UVARIA CHAMAE</I>

Snakebite Envenoming: A Public Health Perspective

Effects of Ethanolic Leaf Extract of Euphorbia hirta on Snake Venom Induced Toxicity in Mice

Contact Info

Product

Resources

About