Neutralization of kinin-releasing enzymes of crotalid venoms by monospecific and polyspecific antivenoms

Phosphodiesterase from Daboia russelli russelli venom: Purification, partial characterization and inhibition of platelet aggregation

“…While testing the potency of commercially available AVS in neutralising DR-PDE, it was observed that despite geographical variation, the antivenom manufactured at Hyderabad, (Southern India) fully inhibits the activity of DR-PDE from snakes of West Bengal (Eastern India). Till date only polyclonal antibodies and heparin are known to inhibit snake venom PDEs (Tokeshi et al, 1998;Decker et al, 1998;Morais et al, 1994;Bailey et al, 1991). Many plants components have been used as folk and traditional medicine as active ingredient against snakebites (Soares et al, 2005;Bhattacharjee and Bhattacharyya, 2013a, b).…”

Enhancement and inhibition of snake venom phosphodiesterase activity by lysophospholipids

“…Many selective inhibitors of each isoenzyme of intracellular PDEs have been developed, which have many advantages in clinical use [14–16]. However, for venom PDE only polyclonal anti‐venom antibodies and heparin have been reported as inhibitors [17–20]. In this report we describe the effect of various lysophospholipids on the activity of snake venom PDE, as well as on intracellular cAMP specific PDE.…”