Neutron activation analysis as a tool for tracing the accumulation of silver nanoparticles in tissues of female mice and their offspring

Zinicovscaia, Inga; Grozdov, Dmitrii; Yushin, Nikita; Ivlieva, A. L.; Petritskaya, E. N.; Рогаткин, Д. А.

doi:10.1007/s10967-019-06746-9

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…The gold content in mothers' blood and liver was higher than in offspring, which is consistent with the assumption about the slow rate of AuNPs' transfer through the blood-placenta barrier. This finding contradicts the data obtained in a similar experiment with silver nanoparticles, where the amount of silver in the offspring's blood was four times higher than in females [23].…”

Section: Discussioncontrasting

confidence: 99%

“…Thus, it can be assumed that the excretion of AuNPs was mostly done by kidneys, while the liver eliminated AuNPs from the bloodstream and stored them, although it could not prevent AuNPs' transfer to the fetus and milk. The opposite results were obtained for silver nanoparticles in [23], the content of silver in kidneys was the lowest compared to other organs.…”

Section: Discussionmentioning

confidence: 67%

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Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

Ivlieva

Petritskaya

Рогаткин

et al. 2023

IJMS

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The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content of gold which crossed the blood–brain barrier was measured using neutron activation analysis and constituted 3.8 ng/g for females and 1.1 ng/g for offspring. Experimental offspring showed no differences in spatial orientation and memory compared to the control, while their anxiety levels increased. Gold nanoparticles influenced the emotional state of mice exposed to nanoparticles during prenatal and early postnatal development, but not their cognitive abilities.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 67%

Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

Ivlieva

Petritskaya

Рогаткин

et al. 2023

IJMS

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“…For the preparation of reference samples, we used a solution of a standard sample of silver in the form of silver nitrate with a silver ion concentration of 1 g/L (LenReaktiv, Saint Petersburg, Russia). INAA has already been successfully used in the study of gold nanoparticle biokinetics [19], as well as in silver nanoparticle biokinetics study for prenatal [20] and oral exposure for subchronic periods of administration [17,21,22].…”

Section: Methodsmentioning

confidence: 99%

Kinetics of Silver Accumulation in Tissues of Laboratory Mice after Long-Term Oral Administration of Silver Nanoparticles

et al. 2021

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Since ancient times, silver has been known for its pronounced bactericidal, antiviral and fungicidal properties. Currently, nanoparticles of this metal are widely used in the food, light and pharmaceutical industries, as well as in medicine. Silver in any form can have a toxic effect not only on pathogens, but also on healthy cells. The biological activity and bioavailability of silver preparations depend on the degree of their solubility in water. In addition, the maximum permissible concentration of soluble forms of silver is an order of magnitude lower than that of insoluble forms. This makes nanoparticles of silver with a hydrophilic coating that form stable colloidal solutions in aqueous media potentially unsafe objects. In this work, we studied the kinetics of the accumulation of silver nanoparticles with an average size of 34 ± 5 nm stabilized with polyvinylpyrrolidone in the organs of laboratory C57Bl/6 mice. The administration of nanoparticles was carried out orally for 30, 60, 120 and 180 days at the dose of 50 µg/day/animal. All the mice developed and gained weight normally during the experiment. No adverse effects were observed. Determination of the silver content in biological tissues of mammals was accomplished by neutron activation analysis. The masses and concentrations of silver in the brain and its different sections (hippocampus, cerebellum, cortex and remnants), as well as in the lungs, testes, liver, blood, kidneys, spleen and heart, were determined. The injection times at which the accumulation curves reached saturation were established. An extremely high accumulation of silver in the testes was shown at 120 days of administration, and a significant accumulation of silver in the lungs and brain was observed. The accumulation of silver in all parts of the brain except the cortex was significant, and its trend was similar to that in the whole brain.

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“…НАА является одним из основных конкурентов ИСП-МС. Однако в отличие от ИСП он не требует перевода образов в раствор и позволяет работать с образцами, масса которых очень мала (как, например, органы мелких лабораторных животных -мышей, крыс) [72]. Одним из основных недостатков метода является работа с радиоактивными образцами.…”

Section: методы количественного определения содержания наночастиц в т...unclassified

Nanoparticles and nanomaterials as inevitable modern toxic agents. Review. Part 2. Main areas of research on toxicity and techniques to measure a content of nanoparticles in tissues

Ivlieva¹,

Zinicovscaia²,

Petritskaya³

et al. 2022

Ekologiya cheloveka (Human Ecology)

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This second part of the review considers the following three main areas of research on the toxicity of nanoparticles (NPs): toxicity of environmental NPs, molecular mechanisms of toxicity, and the reproductive toxicity. The main methods for the quantitative measurements of the content of NPs in biological samples are also considered as the necessary stage of research on the toxicity of NPs for humans and animals.

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Neutron activation analysis as a tool for tracing the accumulation of silver nanoparticles in tissues of female mice and their offspring

Cited by 7 publications

References 22 publications

Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

Kinetics of Silver Accumulation in Tissues of Laboratory Mice after Long-Term Oral Administration of Silver Nanoparticles

Nanoparticles and nanomaterials as inevitable modern toxic agents. Review. Part 2. Main areas of research on toxicity and techniques to measure a content of nanoparticles in tissues

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