Neutron activation analysis of trace elements in skin.

Molokhia, Mohamed M.; Portnoy, Benjamin

doi:10.1111/j.1365-2133.1973.tb07547.x

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Zinc is essential for the normal maturation of the epidermis, a process referred to as terminal differentiation. 44,45 Moynahan and Barnes in 1973 described a congenital disorder caused by zinc deficiency, acrodermatitis entropathica, characterized by a reversible triad consisting of dermatitis, diarrhea, and alopecia. 46 Zinc deficiency is reported to delay wound healing.…”

Section: Trace Elementsmentioning

confidence: 99%

The Role of Nutrition in the Management of Lower Extremity Wounds

Patel

2005

The International Journal of Lower Extremity Wounds

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From 3000 BC, healers have understood the importance of nutrition in wound care and used nutritional supplements to aid healing. Many of the teachings from Hippocrates, the father of modern-day medicine, clearly state his firm belief that good health can be achieved through nutrition. In the early 1900s when advances in biochemistry were frequent, many of the essential constituents of nutrition were characterized, which formed the basis for many animal and human wound-healing experiments. This led to the discovery of vitamin C, zinc, and many other components essential for the orderly progression of healing. Modern-day research has concentrated on finding nutritional components that can enhance healing through supra-physiological doses, such as in the use of the amino acids arginine and carnitine. However, clinicians need to be aware that approximately 50% of patients admitted to the hospital are malnourished, requiring dietary supplementation; appropriate nutritional assessment and advice therefore should be an integral part of all wound management. This review provides an up-to-date commentary on the role of nutrition in wound care, with specific emphasis on lower limb wounds, from a historical perspective, and within it both the biomedical approach and current herbalist practices are considered.

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Section: Trace Elementsmentioning

confidence: 99%

The Role of Nutrition in the Management of Lower Extremity Wounds

Patel

2005

The International Journal of Lower Extremity Wounds

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“…These studies have mainly focused on nonenzymatic aspects of melanins such as cation exchange properties, structural modification by metal ions and rearrangement of dopachrome. 23,24 However, in the melanincontaining tissues there are high qualities of some heavy metals, in particular zinc, copper, and iron, 32 for example, high levels of such metal ions have been found in the choroids of eye, 33,34 black hair, 35 pigmented moles, 36 and human melanomas. 37 The binding of transition metals to the MT leads to the structural and functional changes as a consequence of such interactions.…”

Section: +mentioning

confidence: 99%

Non-Essential Activation of Co²⁺and Zn²⁺on Mushroom Tyrosinase: Kinetic and Structural Stability

Gheibi¹,

Saboury²,

Sarreshtehdari³

2011

Bulletin of the Korean Chemical Society

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Tyrosinase is a widespread enzyme with great promising capabilities. The Lineweaver-Burk plots of the catecholase reactions showed that the kinetics of mushroom tyrosinase (MT), activated by Co 2+ and Zn 2+ at different pHs (6, 7, 8 and 9) obeyed the non-essential activation mode. The binding of metal ions to the enzyme increases the maximum velocity of the enzyme due to an increase in the enzyme catalytic constant (k cat ). From the kinetic analysis, dissociation constants of the activator from the enzyme-metal ion complex (K a ) were obtained as 5 × 10 4 M −1 and 8.33 × 10 3 M −1 for Co 2+ and Zn 2+ at pH 9 and 6 respectively. The structural analysis of MT through circular dichroism (CD) and intensive fluorescence spectra revealed that the conformational stability of the enzyme in these pHs reaches its maximum value in the presence of each of the two metal ions.

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