Neutron Capture Therapy with Gd-DTPA in Tumor-Bearing Rats

Khokhlov, V.F.; Yashkin, P.N.; Silin, Dimitry I.; Djorova, E. S.; Lawaczeck, Rüdiger

doi:10.1007/978-1-4757-9567-7_123

Cited by 9 publications

(2 citation statements)

References 9 publications

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“…At the site of injection, tumor growth was significantly suppressed between days 16 and 23 after Gd-NCT compared to control tumors [22]. The therapeutic effect of Gd-DTPA in vivo was also reported in rats with Jensen's sarcoma [57].…”

Section: Discussionmentioning

confidence: 68%

Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA

Kanygin

Zaboronok

Кичигин

et al. 2023

Veterinary Sciences

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We conducted a clinical veterinary study on neutron capture therapy (NCT) at a neutron-producing accelerator with seven incurable pets with spontaneous tumors and gadolinium as a neutron capture agent (gadolinium neutron capture therapy, or GdNCT). Gadolinium-containing dimeglumine gadopentetate, or Gd-DTPA (Magnevist®, 0.6 mL/kg b.w.), was used. We observed mild and reversible toxicity related to the treatment. However, no significant tumor regression in response to the treatment was observed. In most cases, there was continued tumor growth. Overall clinical improvement after treatment was only temporary. The use of Gd-DTPA for NCT had no significant effects on the life expectancy and quality of life of animals with spontaneous tumors. Further experiments using more advanced gadolinium compounds are needed to improve the effect of GdNCT so that it can become an alternative to boron neutron capture therapy. Such studies are also necessary for further NCT implementation in clinical practice as well as in veterinary medicine.

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Section: Discussionmentioning

confidence: 68%

Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA

Kanygin

Zaboronok

Кичигин

et al. 2023

Veterinary Sciences

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“…In 1993, Schering AG Berlin Company suggested performing the first experiments on neutron capture therapy using gadolinium drug Magnevist™ (manufacturer firm Schering) using the horizontal experimental channel HEC-4 of IRT MEPhI reactor [1,2].…”

Section: Introductionmentioning

confidence: 99%

Facilities for Neutron Capture Therapy at IRT MEPhI Nuclear Reactor

Sheino

Khokhlov

Izhevskiy

et al. 2015

AMR

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One of the problems in developing the neutron capture therapy (NСT) of malignancies is the absence (or unavailability) of neutron sources having necessary intensity and spectrum. The first (and the only so far) experimental medical irradiation units for neutron capture therapy in Russia were created at IRT MEPhI nuclear reactor. At the exit of the tangential channel, there is a device for irradiating superficial tumors by thermal neutrons. A combined beam of thermal and epithermal neutrons that allows processing deep-lying tumors was implemented on the basis of a thermal column.

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Nanoparticles for Neutron Capture Therapy of Cancer

Ichikawa

Tokumitsu

Miyamoto

et al. 2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Principle of Neutron Capture Therapy of Cancer Boron Neutron Capture Therapy Boron Compounds Delivery of Boron Using Nanoparticles Approaches to Gd NCT Typical Research on Gd NCT Delivery of Gadolinium using Lipid Emulsion ( G d ‐ nano LE ) Preparation of Gd ‐ nano LE Biodistribution of Gadolinium after Intraperitoneal Administration of Gd ‐ nano LE Biodistribution of Gadolinium after Intravenous Administration of Gd ‐ nano LE Delivery of Gadolinium using Chitosan Nanoparticles ( Gd ‐ nano CPs ) Preparation of Gd ‐ nano CPs Gd ‐ DTPA Release Property of Gd ‐ nano CPs Gd ‐ DTPA Retention in Tumor Tissue after Intratumoral Injection In vivo Growth Suppression of Experimental Melanoma Solid Tumor Bioadhesion and Uptake of Gd ‐ nano CP in Three Different Cell Lines Conclusions

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Neutron Capture Therapy with Gd-DTPA in Tumor-Bearing Rats

Cited by 9 publications

References 9 publications

Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA

Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA

Facilities for Neutron Capture Therapy at IRT MEPhI Nuclear Reactor

Nanoparticles for Neutron Capture Therapy of Cancer

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