Neutrophil phenotype and function in partial hepatectomy in man

Holzer, Katharina; Hofmann, Dennis; Oppermann, Elsie; Zeuzem, Stefan; Mönch, Christian; Henrich, Dirk; Bechstein, Wolf O.

doi:10.1007/s00423-009-0557-x

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…These studies were grouped by their system of research. The most commonly studied system of research was blood cells (9) [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] followed by whole body (8) [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , blood plasma (4) [39] , [57] , [58] , [59] , tissues (2) [60] , [61] , urine (2) [62] , [63] , saliva (1) [64] , and other cells (1) [65] .…”

Section: Resultsmentioning

confidence: 99%

Ultraweak Photon Emission as a Non-Invasive Health Assessment: A Systematic Review

et al. 2014

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We conducted a systematic review (SR) of the peer reviewed scientific literature on ultraweak photon emissions (UPE) from humans. The question was: Can ultraweak photon emissions from humans be used as a non-invasive health assessment? A systematic search was conducted across eight relevant databases: PubMed/MEDLINE, BIOSIS, CINAHL, PSYCHINFO, All of Cochrane EBM databases, GIDEON, DoD Biomedical Research, and clinicaltrials.gov from database inception to October 2011. Of the 1315 studies captured by the search strategy, 56 met the inclusion criteria, out of which 1 was a RCT, 27 were CCT, and 28 were observational and descriptive studies. There were no systematic reviews/meta-analyses that fit the inclusion criteria. In this report, the authors provide an assessment of the quality of the RCT included; describe the characteristics of all the included studies, the outcomes assessed, and the effectiveness of photon emission as a potential health assessment tool. This report demonstrates that the peer reviewed literature on UPE and human UPE measurement in particular is surprisingly large. Most of the human UPE literature is of good to high quality based on our systematic evaluation. However, an evaluation tool for systematically evaluating this type of “bio-evaluation” methodology is not currently available and would be worth developing. Publications in the peer reviewed literature over the last 50 years demonstrate that the use of “off-the-shelf” technologies and well described methodologies for the detection of human photon emissions are being used on a regular basis in medical and research settings. The overall quality of this literature is good and the use of this approach for determining inflammatory and oxidative states of patients indicate the growing use and value of this approach as both a medical and research tool.

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Section: Resultsmentioning

confidence: 99%

Ultraweak Photon Emission as a Non-Invasive Health Assessment: A Systematic Review

et al. 2014

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“…Furthermore, in the progression phase, neutrophils actively phagocytose apoptotic extracellular vesicles, leading to the secretion of hepatocyte growth factor and fibroblast growth factor‐2, further promoting liver regeneration [ 13 ]. Notably, after partial hepatectomy (PH) or associated liver partition and portal vein ligation for staged hepatectomy, neutrophils and macrophages undergo a phenotypic transition from pro‐inflammatory to pro‐regenerative states as they diligently clear cell debris [ 14 , 15 ].…”

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confidence: 99%

Neutrophil and macrophage crosstalk might be a potential target for liver regeneration

Chen,

Yang,

et al. 2024

FEBS Open Bio

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The regenerative capability of the liver is remarkable, but further research is required to understand the role that neutrophils play in this process. In the present study, we reanalyzed single‐cell RNA sequencing data from a mouse partial hepatectomy (PH) model to track the transcriptional changes in hepatocytes and non‐parenchymal cells. Notably, we unraveled the regenerative capacity of hepatocytes at diverse temporal points after PH, unveiling the contributions of three distinct zones in the liver regeneration process. In addition, we observed that the depletion of neutrophils reduced the survival and liver volume after PH, confirming the important role of neutrophils in liver regeneration. CellChat analysis revealed an intricate crosstalk between neutrophils and macrophages promoting liver regeneration and, using weighted gene correlation network analysis, we identified the most significant genetic module associated with liver regeneration. Our study found that hepatocytes in the periportal zone of the liver are more active than in other zones, suggesting that the crosstalk between neutrophils and macrophages might be a potential target for liver regeneration treatment.

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Immune cell regulation of liver regeneration and repair

Markose

Kirkland

Ramachandran

et al. 2018

Journal of Immunology and Regenerative Medicine

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Neutrophil phenotype and function in partial hepatectomy in man

Abstract: Uneventful partial hepatectomy in man resulted already in a significant change in the phenotype but in less significant changes in the functions of neutrophils.

Cited by 5 publications

References 18 publications

Ultraweak Photon Emission as a Non-Invasive Health Assessment: A Systematic Review

Ultraweak Photon Emission as a Non-Invasive Health Assessment: A Systematic Review

Neutrophil and macrophage crosstalk might be a potential target for liver regeneration

Immune cell regulation of liver regeneration and repair

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