Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio can predict the severity of gallstone pancreatitis

Cho, Seung Kook; Jung, Saehyun; Lee, Kyong Joo; Kim, Jae Woo

doi:10.1186/s12876-018-0748-4

Cited by 61 publications

(55 citation statements)

References 24 publications

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“…Although there were some data regarding the predictive value of NLR in the prognosis of AP in the previous study, there was a lack of data regarding their utilities in specific causes of pancreatitis. Cho et al further reported that NLR and PLR could predict the severity of gallstone AP rather than alcoholic AP. However, the study was limited by enrollment of patients only with etiology of gallstone or alcohol.…”

Section: Discussionmentioning

confidence: 98%

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Huang

Chen

Yang

et al. 2019

Clinical Laboratory Analysis

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Objectives We aimed to evaluate the values of neutrophil‐to‐lymphocyte ratio (NLR) and white blood cell (WBC) in predicting severity of acute pancreatitis (AP) with different etiologies. Methods We compared NLR and WBC levels in patients with different etiologies and AP severity. The optimal cutoff value for them to predict severe acute pancreatitis (SAP) was determined by receiver operating characteristic (ROC) curve analysis. Results Both NLR and WBC were elevated in patients with SAP. After subgrouping AP by etiology, NLR was predictive of SAP only in hypertriglyceridemia‐induced AP (HTG‐AP), while WBC could effectively predict severity in both gallstone and HTG‐AP. The best cutoff value of WBC for predicting SAP in gallstone AP patients was 12.81 × 109/L, with sensitivity and specificity of 78.9% and 70.2%. The best cutoff value for NLR and WBC to differentiate HTG‐SAP was more than 5.88 and 15.89 × 109/L, respectively, with sensitivity and specificity of 87% and 50% for NLR and 56.5% and 75.76% for WBC. Conclusions Our study firstly demonstrated that NLR selectively played a role in HTG‐AP, while WBC could predict the severity of both gallstone and HTG‐AP. Furthermore, we firstly elucidated that NLR was more sensitive and accurate in judging the severity of HTG‐AP compared with WBC.

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Section: Discussionmentioning

confidence: 98%

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Huang

Chen

Yang

et al. 2019

Clinical Laboratory Analysis

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“…11 Activation and modulation of neutrophils and platelets play a core role in establishing host defences in settings of systemic inflammation. 2 Platelet to lymphocyte ratio (PLR) is a relatively novel inflammatory marker that can be utilized for prognosis in various disease processes. Demir et al, investigated the association between high PLR and mortality in patients with acute cardiogenic pulmonary edema and found out that high PLR group had significantly higher mortality rate than other groups.…”

Section: Discussionmentioning

confidence: 99%

“…Acute Pancreatitis (AP) is defined as an acute condition presenting with abdominal pain, a threefold or greater rise in the serum levels of the pancreatic enzymes amylase or lipase, and/or characteristic findings of pancreatic inflammation on contrast enhanced CT. 1 It is an inflammatory process in which local pancreatic injury leads to systemic inflammation through activation of cytokine cascades. 2 The clinical extent of acute pancreatiits varies widely from no symptoms to systemic inflammatory response syndrome (SIRS), persistent organ failure (POF), and death. 3 The clinical signs of acute pancreatitis may be nonspecific and they exhibit a low sensitivity (40%) for the prediction of an adverse outcome.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Many research groups have studied the value of hematological components, such as the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR), in predicting disease severity and outcomes across a variety of diseases, including inflammation, cardiovascular disease, and neoplastic states. 2 Increased NLR and PLR ratios have been associated with inflammatory conditions, and poor outcomes in severe AP. 2 Although a few studies have considered NLR and its prognostic value in AP, there are no studies that have examined the prognostic value of PLR alone in AP.…”

Section: Introductionmentioning

confidence: 99%

“…2 Increased NLR and PLR ratios have been associated with inflammatory conditions, and poor outcomes in severe AP. 2 Although a few studies have considered NLR and its prognostic value in AP, there are no studies that have examined the prognostic value of PLR alone in AP. 4 As PLR is easily derivable value, in the present study we evaluated the PLR value as a prognostic factor for the outcome of Acute pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

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Role of platelet to lymphocyte ratio in assessing prognosis in acute pancreatitis

et al. 2019

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Background: Acute pancreatitis is a common condition associated with morbidity and mortality. The incidence of acute pancreatitis (AP) has been increasing worldwide. Recent advances in diagnostic and therapeutic management in acute pancreatitis (AP) remarkably decreased the mortality rate. Assessing severity of acute pancreatitis at an early stage will further decrease the mortality rate and will help to initiate appropriate treatment as early as possible to prevent mortality. Many clinical, laboratory, and radiological factors and scoring systems are used to predict severity and prognosis of AP, but none is ideal. In low resource setting, costly laboratory tests are not readily available. Platelet to lymphocyte ratio (PLR) is an easily derivable, cost effective and applicable blood test. Platelet to lymphocyte ratio (PLR) is a relatively novel inflammatory marker and can predict severity in various diseases. In this study, we evaluated the value of PLR as prognostic factor in acute pancreatitis (AP).Methods: This prospective study was conducted on 256 patients admitted to S.V.R.R.G.G. Hospital, with the diagnosis of acute pancreatitis, from April 2017 to September 2018. Patients with Acute Pancreatitis were divided into tertiles based on the values of PLR at admission, a PLR of less than 150 as 1st tertile, a PLR of 150-300 as 2nd tertile and a PLR of more than 300 as 3rd tertile. The outcomes assessed were intensive care unit (ICU) admission, length of stay (LOS) in the hospital and death.Results: According to PLR tertiles, patients in the 3rd tertile (PLR>300) had significantly more ICU admissions, 59 (71%) and longer average Length of Hospital Stay (LOS) of survivors,18+/-5 days and higher mortality, 24 (28.9%), compared with those in the 1st tertile (PLR<150).Conclusions: PLR is an easily derivable, cost effective prognostic factor which can predict the outcome of acute pancreatitis. In this study, we established that high PLR value is associated with very bad prognosis and poor outcome or death in Acute pancreatitis.

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Leukocytes are not Reliable in Predicting Possible Diaphragmatic Injury in Patients with Penetrating Left Thoracoabdominal Stab Wounds

Yücel

Yildiz

2021

World j. surg.

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Background The diaphragm is injured in approximately one-third of penetrating left thoracoabdominal stab wounds. Diagnostic laparoscopy or thoracoscopy is performed to reveal the diaphragmatic injury. This study investigated whether leukocytes, leukocyte subgroups, platelets, the neutrophil-to-lymphocyte ratio (NLR), and the thrombocyteto-lymphocyte ratio (PLR) can be used to detect diaphragm injury without the need for diagnostic laparoscopy. Methods Patients hospitalized between January 2010 and January 2020 due to penetrating left thoracoabdominal stab wounds were examined. Laparotomy was performed in patients who had indications for laparotomy, such as hemodynamic instability and peritonitis. Diagnostic laparoscopy was performed to reveal possible diaphragmatic injury in patients who did not require laparotomy after 48h of follow-up. Leukocytes, leukocyte subgroups, platelets, NLR, and PLR were measured both at admission and during follow-up, and the results were compared between patients with and without diaphragm injury during diagnostic laparoscopy. ResultsThe study included 108 patients with penetrating left thoracoabdominal stab wounds that did not require laparotomy after 48h of follow-up. Of these, 102 patients were male (94.44%), and the average age was 27.68 years (range 15-66 years). Diaphragm injury was detected in 31 patients (28.70%) in diagnostic laparoscopy, and the diaphragm was intact in 77 patients (71.30%). In the comparison of patients with and without diaphragmatic injury, no statistically significant difference was found in terms of age, gender, platelets, leukocyte values, NLR, and PLR both at admission and during follow-up. Conclusions Leukocytes, leukocyte subsets, platelets, NLR, and PLR were insufficient in the detection of asymptomatic diaphragmatic injuries caused by penetrating left thoracoabdominal stab wounds.

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Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio can predict the severity of gallstone pancreatitis

Cited by 61 publications

References 24 publications

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Role of platelet to lymphocyte ratio in assessing prognosis in acute pancreatitis

Leukocytes are not Reliable in Predicting Possible Diaphragmatic Injury in Patients with Penetrating Left Thoracoabdominal Stab Wounds

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