Nevirapine Loaded Core Shell Gold Nanoparticles by Double Emulsion Solvent Evaporation: In vitro and In vivo Evaluation

Dalvi, Bhagyashree; Siddiqui, Ejaz Ahmad; Syed, Asad; Velhal, Shilpa; Ahmad, Absar; Bandivdekar, Atmaram B.; Devarajan, Padma V.

doi:10.2174/1567201813666160114093005

Cited by 10 publications

(12 citation statements)

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“…The increase in the MRT was especially relevant in important HIV reservoirs, such as the liver and spleen, but also in the thymus and brain. In fact, similar results have been shown with gold nanoparticles for other antiretroviral drugs [32].…”

Section: Discussionsupporting

confidence: 83%

Physiologically Based Pharmacokinetic (PBPK) Model of Gold Nanoparticle-Based Drug Delivery System for Stavudine Biodistribution

et al. 2022

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Computational modelling has gained attention for evaluating nanoparticle-based drug delivery systems. Physiologically based pharmacokinetic (PBPK) modelling provides a mechanistic approach for evaluating drug biodistribution. The aim of this work is to develop a specific PBPK model to simulate stavudine biodistribution after the administration of a 40 nm gold nanoparticle-based drug delivery system in rats. The model parameters used have been obtained from literature, in vitro and in vivo studies, and computer optimization. Based on these, the PBPK model was built, and the compartments included were considered as permeability rate-limited tissues. In comparison with stavudine solution, a higher biodistribution of stavudine into HIV reservoirs and the modification of pharmacokinetic parameters such as the mean residence time (MRT) have been observed. These changes are particularly noteworthy in the liver, which presents a higher partition coefficient (from 0.27 to 0.55) and higher MRT (from 1.28 to 5.67 h). Simulated stavudine concentrations successfully describe these changes in the in vivo study results. The average fold error of predicted concentrations after the administration of stavudine-gold nanoparticles was within the 0.5–2-fold error in all of the tissues. Thus, this PBPK model approach may help with the pre-clinical extrapolation to other administration routes or the species of stavudine gold nanoparticles.

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Section: Discussionsupporting

confidence: 83%

Physiologically Based Pharmacokinetic (PBPK) Model of Gold Nanoparticle-Based Drug Delivery System for Stavudine Biodistribution

et al. 2022

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“…Resulting nanocapsules had a uniform size (approximately 450 nm) and hollow morphology with a loading efficiency up to 90%. Core–shell nanoparticles of gold nanoparticles (AuNPs) and nevirapine (NVP) prepared from double emulsion‐solvent evaporation were developed by Dalvi and co‐workers . The designed core–shell nanoparticles were aimed at targeting delivery to multiple HIV reservoirs.…”

Section: Techniques To Produce Pharmacological Nanoparticlesmentioning

confidence: 99%

“…The release of 17‐AAG at 40 °C was higher than that of room temperature due to shrinkage of the core–shell nanoparticles at temperature above the lower critical solution temperature of PNIPAM, resulting in drug release. Dalvi et al designed the nanoparticles for targeted HIV reservoir by loading nevirapine in gold nanoparticles (AuNPs) using double emulsion‐solvent evaporation . AuNPs were mixed with DCM containing NVP, glyceryl monostearate (GMS), and dioctyl sulfosuccinate sodium salt (AOT).…”

Section: Pharmacological Nanoparticles From Emulsion Techniquesmentioning

confidence: 99%

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Jenjob

Phakkeeree

Seidi

et al. 2019

Macromolecular Bioscience

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Nanoparticles have the advantages over micron‐sized particles to typically provide higher intracellular uptake and drug bioavailability. Emulsion techniques are commonly used methods for producing nanoparticles aiming at high encapsulation efficiency, high stability, and low toxicity. Here, the recent developments of nanoparticles prepared from emulsions, the synthesis of nanoparticles, their physicochemical properties, and their biomedical applications are discussed. Selection of techniques, such as emulsion polymerization, miniemulsion polymerization, microemulsion polymerization, and emulsion‐solvent evaporation processes, strongly influences morphologies, size distributions, and particle properties. Details in the synthetic strategies governing the performance of nanoparticles in bioimaging, biosensing, and drug delivery are presented. Benefits and limitations of molecular imaging techniques are also discussed.

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“…60 But once again, the improved viral reserve tissue accumulation was accompanied by increased off-site accumulation in the liver and ovaries. 60 Such off-site accumulation of nanomaterials is concerning given the potential cytotoxicity of inorganic NPs, making the use of a more biocompatible system necessary. Additionally, since most inorganic NPs are not biodegradable, their size is often limited to several nanometers in order to facilitate renal clearance.…”

Section: Inorganic Npsmentioning

confidence: 98%

“…Another proposed delivery system of glyceryl monostearate‐modified, nevirapine loaded gold shell NPs displayed similar increased uptake by PBMCs and sustained accumulation in viral reservoirs such as the spleen, lymph nodes, thymus, bone marrow, and brain . But once again, the improved viral reserve tissue accumulation was accompanied by increased off‐site accumulation in the liver and ovaries . Such off‐site accumulation of nanomaterials is concerning given the potential cytotoxicity of inorganic NPs, making the use of a more biocompatible system necessary.…”

Section: Nanostructured Systems For the Treatment Of Hivmentioning

confidence: 99%

Harnessing nanostructured systems for improved treatment and prevention of HIV disease

Monroe

Flexner

Cui

2018

Bioengineering & Transla Med

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Combination antiretroviral therapy effectively controls human immunodeficiency virus (HIV) viral replication, delaying the progression to acquired immune deficiency syndrome and improving and extending quality of life of patients. However, the inability of antiretroviral therapeutics to target latent virus and their poor penetration of viral reserve tissues result in the need for continued treatment for the life of the patient. Side effects from long‐term antiretroviral use and the development of drug resistance due to patient noncompliance are also continuing problems. Nanostructured systems of antiretroviral therapeutics have the potential to improve targeted delivery to viral reservoirs, reduce drug toxicity, and increase dosing intervals, thereby improving treatment outcomes and enhancing patient adherence. Despite these advantages, very few nanostructured antiretroviral delivery systems have made it to clinical trials due to challenges in preclinical and clinical development. In this context, we review the current challenges in HIV disease management, and the recent progress in leveraging the unique performance of nanostructured systems in therapeutic delivery for improved treatment and prevention of this incurable human disease.

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Nevirapine Loaded Core Shell Gold Nanoparticles by Double Emulsion Solvent Evaporation: In vitro and In vivo Evaluation

Cited by 10 publications

References 0 publications

Physiologically Based Pharmacokinetic (PBPK) Model of Gold Nanoparticle-Based Drug Delivery System for Stavudine Biodistribution

Physiologically Based Pharmacokinetic (PBPK) Model of Gold Nanoparticle-Based Drug Delivery System for Stavudine Biodistribution

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Harnessing nanostructured systems for improved treatment and prevention of HIV disease

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