Nevus Comedonicus: A Case Series

Abstract

Twelve previously unreported cases of nevus comedonicus are presented. Characteristic closely grouped dilated follicular openings with horny plugs that mimic comedones led to the diagnosis. One patient had nevus comedonicus syndrome and there were cases with atypical locations and unusual complications of this condition. We also highlight clinical associations and therapeutic options.

Further delineation of the phenotypic spectrum of nevus comedonicus syndrome to include congenital pulmonary airway malformation of the lung and aneurysm

“… Note : Search details included: (“naevus”[All Fields] OR “nevus, pigmented”[MeSH Terms] OR (“nevus”[All Fields] AND “pigmented”[All Fields]) OR “pigmented nevus”[All Fields] OR “nevus”[All Fields] OR “nevus”[MeSH Terms]) AND comedonicus[All Fields] AND (“syndrome”[MeSH Terms] OR “syndrome”[All Fields]). References: (Kaliyadan, Nampoothiri, Sunitha, & Kuruvilla, ; Patrizi, Neri, Fiorentini, & Marzaduri, ; Pavithra, Pai, Mallya, & Pai, ; Ferrari et al, ; Suite and Mahabir, ; Seo, Piao, Suhr, Lee, & Park, ; Yadav, Mendiratta, Rana, & Chander, ; Qian, Liu, Zhou, & Zhang, ; Engber, , ; Whyte, ; Ghelbazouri et al, ; Alpsoy, Durusoy, Ozbilim, Karpuzoğlu, & Yilmaz, ; Ito, Mitamura, Tsuji, Harada, & Urabe, ; Vidaurri‐de la Cruz, Tamayo‐Sánchez, Durán‐McKinster, de la Luz Orozco‐Covarrubias, & Ruiz‐Maldonado, ; Martinez, Levrero, Bazzano, Larre Borges, & De Anda, ; Filosa, Bugatti, Ciattaglia, Salaffi, & Carotti, ). NC has been seen in patients with dual diagnoses such as orofacial digital syndrome (Baker & Agim, ) and Alagille syndrome (Woods, Larcher, & Harper, ).…”

“…Congenital pulmonary airway malformations are developmental abnormalities of the lung that consist of a spectrum of cystic and noncystic lung lesions. The incidence of CPAMs is estimated at 1 in 11,000 to 1 in 35,000 live births (Gornall, Budd, Draper, Konje, & Kurinczuk, 2003;Laberge et al, 2001;Leblanc et al, 2017) (Kaliyadan, Nampoothiri, Sunitha, & Kuruvilla, 2010;Patrizi, Neri, Fiorentini, & Marzaduri, 1998;Pavithra, Pai, Mallya, & Pai, 2011;Ferrari et al, 2015;Suite and Mahabir, 1994;Seo, Piao, Suhr, Lee, & Park, 2001;Yadav, Mendiratta, Rana, & Chander, 2015;Qian, Liu, Zhou, & Zhang, 2015;Engber, 1978Engber, , 1982Whyte, 1968;Ghelbazouri et al, 2007 (Baker & Agim, 2014) and Alagille syndrome (Woods, Larcher, & Harper, 1994). Abbreviation: Unk, unknown.…”

Birt–Hogg–Dubé Syndrome Presenting as a Nevus Comedonicus–Like Lesion in an 8‐Year‐Old Boy

“…This case reinforces the important role dermatology plays in the early diagnosis of BHD syndrome. It also highlights a newly described lesion associated with BHD syndrome, which in this case was present at birth mimicking a nevus comedonicus, a rare lesion with an estimated prevalence of 1 in 45,000 . Although nevus comedonicus is generally not associated with BHD syndrome, the presence in an infant with a known family history of BHD syndrome or its associated symptoms should prompt investigation for BHD syndrome.…”

Hair Follicle Nevus With Features of Comedo Nevus

“…29,30 Comedo nevus is clinically characterized by multiple, grouped linearly distributed open comedones that follow the lines of Blaschko. 31 In contrast, HFN is characterized most frequently by pedunculated papulonodules, or rarely as a plaque. Histopathologically, comedo nevi are composed of dilated follicular structures filled with lamellated keratinous debris, widely dilating the infundibula, frequently resulting in the cystic dilatation that affects almost the entire hair follicle.…”