New Advances in Large-Volume Injection Gas Chromatography-Mass Spectrometry

Large-volume injection combined with gas chromatography/isotope ratio mass spectrometry for the analysis of polycyclic aromatic hydrocarbons

“…LVI increases the method sensitivity for analytes with low concentrations by injecting a larger volume of a sample; it may also simplify the sample pretreatment by reducing or shortening the sample evaporation step . The principle of LVI involves the injection of a sample, during which the split exit is open and high flow of gas (typically 75–250 mL min –1 ) passes through the injector to enhance the fast evaporation of the solvent.…”

“…The principle of LVI involves the injection of a sample, during which the split exit is open and high flow of gas (typically 75–250 mL min –1 ) passes through the injector to enhance the fast evaporation of the solvent. The temperature of the injector is usually kept below the solvent boiling point, thus greatly reducing the discrimination of less volatile components of a sample . Moreover, thermal degradation is minimized, since the residence time of the analytes at elevated temperatures is reduced compared with that in the conventional hot injection .…”

Recent Advances in Environmental Analysis

“…In addition to the common on-column injection and temperature vaporizer injection modes, alternative LVI sample introduction methods including that based on the through oven transfer adsorption desorption interface have been used for purposes such as multiresidue analysis of pesticides . General advances in LVI-GC/MS (injection systems, sample treatment, and outstanding applications) in the past decade were recently discussed …”

“…107 General advances in LVI-GC/MS (injection systems, sample treatment, and outstanding applications) in the past decade were recently discussed. 108 Major trends in the use of GC stationary phases during the last two years include the use of narrow-bore capillary columns for fast GC and the development of more selective ionic liquid-based stationary phases to enhance separation. The use of narrow-bore capillary columns for fast, high-throughput GC is on the increase.…”