New agents for pleurodesis

Abstract

At times when patients have a malignant pleural effusion or a pneumothorax, one wishes to eliminate the pleural space by pleurodesis. This article describes results from attempting pleurodesis with silver nitrate, iodopovidone (betadine), transforming growth factor beta (TGFβ), OK432, and lipoteichoic acid-T. The two most promising agents seem to be silver nitrate and iodopovidone. Both agents induce pleurodesis that is at least comparable with that produced by talc, and neither induced the acute respiratory distress syndrome that sometimes occurs after intrapleural administration of talc.

Outcome of pleurodesis using different agents in management prolonged air leakage following lung resection

“…The negative side effect of the pleural application of sclerosing agents was pain and other complications . The evaluation of intensity of pain after pleurodesis is very subjective.…”

Pleurodesis with Thulium Cyber Laser versus talc poudrage: a comparative experimental study

“…The search for the ideal sclerosing substance has developed a number of studies, progressively improving the spectrum of medication offered for intrapleural injection [1,2]. Although bed-side procedure is the most common when attempting at pleural cavity obliteration, pleurodesis is often indicated during thoracoscopy.…”

“…If we consider the supreme features of a pleurodesis agent, we see that there is currently no one which suits every situation and research should focus not only on the discovery of the Bideal substance^but also on the appropriateness of using the already available instruments [1,2]. For this reason, the technique for efficient and riskless pleurodesis needs to be tailored on specific clinical, prognostic, demographic, and pathological standpoints.…”