New and Cytotoxic Components from Antrodia camphorata

Abstract

Abstract:The solid-state cultured products of Antrodia camphorata as health foods has been blooming for the past few decades in Taiwan. In continuing our studies on the chemical constituents of the solid-state cultured products of this fungus, 6-methoxy-4-methyl-2,3-(methylenedioxy)phenol (1) and 4,4'-(ethane-1,2-diyl)bis(2,3,6-trimethoxyphenol)(2) together with 2,3,6-trimethoxy-4-methylphenol (3), 1(10→6)abeo-ergosta-5,7,9,22-tetraen-3α-ol (4), citreoanthrasteroid B (5) and dankasterones A (6) and B (7) were purified by a series of column chromatography. Their structures were elucidated by spectral data analysis. For bioactivity assay, compounds 4-7 showed significant cytotoxicity toward murine colorectal CT26 and human leukemia K562 cancer cell lines with IC50 values ranging from 6.7 to 15.3 µM and from 12.5 to 23.1 µM, respectively.

A review on the cultivation, bioactive compounds, health-promoting factors and clinical trials of medicinal mushrooms Taiwanofungus camphoratus, Inonotus obliquus and Tropicoporus linteus

“…Steroids ( 34–37 ) isolated from the medicinal mushroom have exhibited cytotoxic activities against murine colorectal and human leukemia cancer cell lines [ 68 ]. Furthermore, ergosterol ( 38 ) obtained from T. camphoratus was recently found to significantly reduce nuclear factor kappa B (NF-κB) phosphorylation, microglial activation–associated ionized calcium-binding adapter molecule-1 (IBA-1), and LPS-induced neuron damage, therefore making it an effective anti-neuroinflammatory agent [ 69 ].…”

Antiinflammatory and Antiphotodamaging Effects of Ergostatrien-3β-ol, Isolated from Antrodia camphorata, on Hairless Mouse Skin

“…Because of its rarity and difficult cultivation, A. camphorata is a highly valued polypore mushroom that is native only to Taiwan [17,18]. The fruiting body and cultured mycelia are composed of fatty acids, lignans, sesquiterpenes, and triterpenoids [19]. Furthermore, the mycelia from submerged culture is used in health food and nutraceuticals [20].…”

Synthesis of Swinhoeisterol A, Dankasterone A and B, and Periconiastone A by Radical Framework Reconstruction

“…Thus, also a certain geographical proximity between the respective grounds of isolation of these and the former natural products is evident. Cytotoxic activities in murine P388 as well as human cancer cell lines CT26 and K562 have been reported . Very recently, periconiastone A ( 3 ) was isolated from cultures of the endophytic fungus Periconia sp.…”

“…Cytotoxic activities in murine P388 as well as human cancer cell lines CT26 and K562 have been reported. 11 Very recently, periconiastone A (3) was isolated from cultures of the endophytic fungus Periconia sp. TJ403-rc01 and showed significant antibacterial properties against MRSA (4 μg/mL).…”